Intractable epilepsy due to angiocentric glioma: A case report and minireview

Chen,Guoqiang; Wang,Lin; Wu,Jinting; Jin,Yongjian; Wang,Xiaosong; Jin,Yulan

doi:10.3892/etm.2013.1402

Intractable epilepsy due to angiocentric glioma: A case report and minireview

Authors:
- Guoqiang Chen
- Lin Wang
- Jinting Wu
- Yongjian Jin
- Xiaosong Wang
- Yulan Jin
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Affiliations: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing 100049, P.R. China, Department of Pathology, Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China
Published online on: November 11, 2013 https://doi.org/10.3892/etm.2013.1402
Pages: 61-65

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Abstract

The aim of this case report and minireview was to investigate the diagnosis of and therapeutic approaches for angiocentric glioma (AG) and to summarize the clinical manifestations and the pathological and imaging characteristics of the disease. Intraoperative cortical electroencephalogram (ECoG) monitoring was performed to locate the epileptic foci in a child with AG who presented with intractable epilepsy, prior to the total resection of the tumor being performed under the microscope. The clinical features, imaging characteristics, intraoperative conditions, surgical methods and pathological results were analyzed and compared with the literature. The review revealed that to date, the clinical features of the 52 reported cases of AG (including this case) have been mainly characterized by epilepsy. High T2‑weighted image (WI) and fluid‑attenuated inversion recovery (FLAIR) signals may be detected with magnetic resonance imaging (MRI) scanning of the cranium; however, no enhancement signals are detected by enhanced scanning. The prognosis following surgical resection is favorable. The lesions in the present case demonstrated clear boundaries with a central cystic affection accompanied by an arachnoid cyst on the left temporal pole. Pathological examination revealed that the lesion was positive for glial fibrillary acidic protein (GFAP), S‑100 protein, vimentin, epithelial membrane antigen (EMA), cluster of differentiation 99 (CD99) and D2‑40. The Ki‑67/MIBk‑1 labeling index was ~1%. In conclusion, AG exhibits characteristic features in imaging; however, its diagnosis depends on histopathological examination. The prognosis of total surgical resection is good and intraoperative ECoG may be used to assist positioning.

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