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Article

Expression of N‑cadherin proteins in myocardial hypertrophy in rats

  • Authors:
    • Lingmin Mu
    • Changqin Jing
    • Zhikun Guo
  • View Affiliations / Copyright

    Affiliations: Morphological Laboratory, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Life Science and Technology Department, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Key Open Laboratory for Tissue Regeneration in Henan Province, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
  • Pages: 355-359
    |
    Published online on: November 28, 2013
       https://doi.org/10.3892/etm.2013.1431
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Abstract

The aim of the present study was to examine the expression of N-cadherin in the myocardial tissues of isoproterenol‑induced myocardial hypertrophy in rats. In addition, the present study provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse myocardial hypertrophy. A myocardial hypertrophy model was established by subcutaneously injecting isoprenaline into healthy adult Sprague‑Dawley rats. The myocardial tissue was collected, embedded in conventional paraffin, sectioned and stained with hematoxylin and the pathological changes were observed. The expression and distribution of N‑cadherin were detected by immunohistochemistry (IHC) and the changes in mRNA expression of N-cadherin in the myocardial tissues of rats were detected by reverse transcription polymerase chain reaction. Image analysis software was used to quantitatively analyze the expression of N‑cadherin. The IHC and immuno­fluorescence results showed that there was no statistically significant difference between the experimental and control groups in the positive expression of N-cadherin. Furthermore, mRNA expression of N‑cadherin, in the myocardial tissues of rats, was consistent with the IHC and immunofluorescence results. Thus, N‑cadherin may have a significant function in the occurrence and development of myocardial hypertrophy.
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Copy and paste a formatted citation
Spandidos Publications style
Mu L, Jing C and Guo Z: Expression of N‑cadherin proteins in myocardial hypertrophy in rats. Exp Ther Med 7: 355-359, 2014.
APA
Mu, L., Jing, C., & Guo, Z. (2014). Expression of N‑cadherin proteins in myocardial hypertrophy in rats. Experimental and Therapeutic Medicine, 7, 355-359. https://doi.org/10.3892/etm.2013.1431
MLA
Mu, L., Jing, C., Guo, Z."Expression of N‑cadherin proteins in myocardial hypertrophy in rats". Experimental and Therapeutic Medicine 7.2 (2014): 355-359.
Chicago
Mu, L., Jing, C., Guo, Z."Expression of N‑cadherin proteins in myocardial hypertrophy in rats". Experimental and Therapeutic Medicine 7, no. 2 (2014): 355-359. https://doi.org/10.3892/etm.2013.1431
Copy and paste a formatted citation
x
Spandidos Publications style
Mu L, Jing C and Guo Z: Expression of N‑cadherin proteins in myocardial hypertrophy in rats. Exp Ther Med 7: 355-359, 2014.
APA
Mu, L., Jing, C., & Guo, Z. (2014). Expression of N‑cadherin proteins in myocardial hypertrophy in rats. Experimental and Therapeutic Medicine, 7, 355-359. https://doi.org/10.3892/etm.2013.1431
MLA
Mu, L., Jing, C., Guo, Z."Expression of N‑cadherin proteins in myocardial hypertrophy in rats". Experimental and Therapeutic Medicine 7.2 (2014): 355-359.
Chicago
Mu, L., Jing, C., Guo, Z."Expression of N‑cadherin proteins in myocardial hypertrophy in rats". Experimental and Therapeutic Medicine 7, no. 2 (2014): 355-359. https://doi.org/10.3892/etm.2013.1431
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