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Article

Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter

  • Authors:
    • Yong Feng
    • Jun‑Feng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 423-428
    |
    Published online on: December 6, 2013
       https://doi.org/10.3892/etm.2013.1439
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Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid that is involved in a variety of physiological and pathological processes occurring in the gastrointestinal tract. It acts via six distinct types of receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, which belong to the family of G protein‑coupled receptors. The aim of the present study was to detect the expression of the LPA receptors in the human lower esophageal sphincter (LES). Quantitative polymerase chain reaction and western blotting were used to analyze the expression of LPA1‑6 receptors in sling and clasp fibers from the human LES. The results showed that the protein and mRNA expression levels of various LPA receptors were significantly different. Specifically, the mRNA and protein expression levels of the LPA1 receptor were higher compared with those of the other receptors. The prevalence of the LPA1 receptor mRNA and protein indicates that the LPA1 receptor is likely to be involved in the regulation of human LES functions.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y and Liu JF: Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Exp Ther Med 7: 423-428, 2014.
APA
Feng, Y., & Liu, J. (2014). Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Experimental and Therapeutic Medicine, 7, 423-428. https://doi.org/10.3892/etm.2013.1439
MLA
Feng, Y., Liu, J."Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter". Experimental and Therapeutic Medicine 7.2 (2014): 423-428.
Chicago
Feng, Y., Liu, J."Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter". Experimental and Therapeutic Medicine 7, no. 2 (2014): 423-428. https://doi.org/10.3892/etm.2013.1439
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y and Liu JF: Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Exp Ther Med 7: 423-428, 2014.
APA
Feng, Y., & Liu, J. (2014). Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Experimental and Therapeutic Medicine, 7, 423-428. https://doi.org/10.3892/etm.2013.1439
MLA
Feng, Y., Liu, J."Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter". Experimental and Therapeutic Medicine 7.2 (2014): 423-428.
Chicago
Feng, Y., Liu, J."Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter". Experimental and Therapeutic Medicine 7, no. 2 (2014): 423-428. https://doi.org/10.3892/etm.2013.1439
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