Correlation of Doppler parameters with renal pathology: A study of 992 patients

Chen,Qinkai; He,Feng; Feng,Xiaoran; Luo,Zhengmao; Zhang,Jianlin; Zhang,Li; Wang,Yu; Tong,Junrong

doi:10.3892/etm.2013.1442

2014-February Volume 7 Issue 2

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2014-February Volume 7 Issue 2

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Article

Correlation of Doppler parameters with renal pathology: A study of 992 patients

Authors:
- Qinkai Chen
- Feng He
- Xiaoran Feng
- Zhengmao Luo
- Jianlin Zhang
- Li Zhang
- Yu Wang
- Junrong Tong
View Affiliations / Copyright

Affiliations: Department of Nephrology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Nephrology, General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong 510010, P.R. China
Pages: 439-442
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Published online on: December 10, 2013

https://doi.org/10.3892/etm.2013.1442
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Abstract

Ultrasound examination is a non‑invasive diagnostic technique that is used on patients with suspected or established renal disease. The purpose of this study was to determine the role of intrarenal Doppler ultrasonography in the assessment of the renal pathology of patients with chronic kidney disease (CKD), as shown by kidney biopsy. This retrospective analysis enrolled 992 consecutive patients with CKD who underwent intrarenal Doppler ultrasonography and a kidney biopsy at the Departments of Nephrology of three hospitals between January 2006 and December 2010. Doppler parameters, including the peak systolic velocity (PSV), end‑diastolic velocity and resistive index (RI) of the interlobar arteries, were compared with the renal biopsy findings. The RI of the interlobar arteries was correlated with the estimated glomerular filtration rate and the histological damage scores, demonstrating the most evident correlation with the tubulointerstitial damage (TI) score among the three histological components. The PSV of the interlobar arteries increased as the CKD stage progressed and correlated with a number of the renal histological changes, including the glomerulosclerosis and TI scores. The RI and PSV of the interlobar artery are correlated with the histopathological pattern in CKD. Thus, the RI and PSV of the interlobar artery may be potential indicators for monitoring the progression of renal damage.

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1	Gao J, Ng A, Shih G, Goldstein M, Kapur S, Wang J and Min RJ: Intrarenal color duplex ultrasonography: a window to vascular complications of renal transplants. J Ultrasound Med. 26:1403–1418. 2007.PubMed/NCBI
2	Park SB, Kim JK and Cho KS: Complications of renal transplantation: ultrasonographic evaluation. J Ultrasound Med. 26:615–633. 2007.PubMed/NCBI
3	Langer JE and Jones LP: Sonographic evaluation of the renal transplant. Ultrasound Clin. 2:73–88. 2007. View Article : Google Scholar
4	Sugiura T, Nakamori A, Wada A and Fukuhara Y: Evaluation of tubulointerstitial injury by Doppler ultrasonography in glomerular diseases. Clin Nephrol. 61:119–126. 2004. View Article : Google Scholar : PubMed/NCBI
5	Parolini C, Noce A, Staffolani E, Giarrizzo GF, Costanzi S and Splendiani G: Renal resistive index and long-term outcome in chronic nephropathies. Radiology. 252:888–896. 2009. View Article : Google Scholar : PubMed/NCBI
6	Hanamura K, Tojo A, Kinugasa S, Asaba K and Fujita T: The resistive index is a marker of renal function, pathology, prognosis, and responsiveness to steroid therapy in chronic kidney disease patients. Int J Nephrol. 2012:1395652012. View Article : Google Scholar : PubMed/NCBI
7	National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 39(Suppl 1): S1–S266. 2002.PubMed/NCBI
8	Gao J, Chevalier J, Auh YH, Rubin JM, Wang H, Sun LN, Seshan S and Min R: Correlation between Doppler parameters and renal cortical fibrosis in lupus nephritis: a preliminary observation. Ultrasound Med Biol. 39:275–282. 2013. View Article : Google Scholar : PubMed/NCBI
9	Asaba K, Tojo A, Onozato ML, Kinugasa S, Miyazaki H, Miyashita K, Uehara Y, Hirata Y, Kimura K, Goto A, Omata M and Fujita T: Long-term renal prognosis of IgA nephropathy with therapeutic trend shifts. Intern Med. 48:883–890. 2009. View Article : Google Scholar : PubMed/NCBI
10	Miletić D, Fuckar Z, Sustić A, Mozetic V, Stimac D and Zauhar G: Sonographic measurement of absolute and relative renal length in adults. J Clin Ultrasound. 26:185–189. 1998.PubMed/NCBI
11	Sustić A, Mavrić Z, Fuckar Z, Miletić D, Mozetic V and Mlinarić B: Kidney length in postoperative acute renal failure. J Clin Ultrasound. 26:251–255. 1998.PubMed/NCBI
12	Liu Y: Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 7:684–696. 2011. View Article : Google Scholar : PubMed/NCBI
13	Bigé N, Lévy PP, Callard P, Faintuch JM, Chigot V, Jousselin V, Ronco P and Boffa JJ: Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease. BMC Nephrol. 13:1392012.PubMed/NCBI
14	Krumme B: Renal Doppler sonography - update in clinical nephrology. Nephron Clin Pract. 103:c24–c28. 2006. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation of Doppler parameters with renal pathology: A study of 992 patients

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