Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance

Wang,Gui-Jun; Wang,Yu-Bin; Li,Di-Nuo; Li,Chen; Deng,Bei-Bei

doi:10.3892/etm.2013.1448

2014-February Volume 7 Issue 2

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2014-February Volume 7 Issue 2

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Article

Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance

Authors:
- Gui-Jun Wang
- Yu-Bin Wang
- Di-Nuo Li
- Chen Li
- Bei-Bei Deng
View Affiliations / Copyright

Affiliations: Department of General Surgery, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China, Liaoning Province Key Laboratory of Medical Tissue Engineering, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China, Department of Gynecology, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China
Pages: 513-517
|
Published online on: December 13, 2013

https://doi.org/10.3892/etm.2013.1448
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Abstract

The aim of this study was to explore the expression of tissue factor pathway inhibitor-2 (TFPI-2) in gastric stromal tissue and its clinical significance. TFPI-2 expression was detected by immunohistochemical analysis, RT-PCR and western blotting in tumor, peritumoral and gastric normal tissues from 72 patients with gastric stromal tumors. The level of TFPI-2 expression was observed to be significantly higher in gastric normal tissue than in peritumoral tissue, and was significantly higher in peritumoral tissue than in tumor tissue (P﹤0.01). As the NIH grade increased, the level of TFPI-2 expression decreased (P﹤0.01). A low expression level of TFPI-2 was closely associated with invasion and metastasis of gastric stromal tumors. In conclusion, the level of TFPI-2 expression was higher in gastric normal tissue than in gastric stromal tumors. Low expression levels of TFPI-2 may be associated with invasion and metastasis of gastric stromal tumors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance

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