Differences in the development of autogenous nerves between the upper and lower urinary tract

Chen,Qimin; Cai,Jinquan; Shi,Chengren; Sun,Jie; Yin,Minzhi; Shen,Ping

doi:10.3892/etm.2013.888

March 2013 Volume 5 Issue 3

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March 2013 Volume 5 Issue 3

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Article

Differences in the development of autogenous nerves between the upper and lower urinary tract

Authors:
- Qimin Chen
- Jinquan Cai
- Chengren Shi
- Jie Sun
- Minzhi Yin
- Ping Shen
View Affiliations / Copyright

Affiliations: Department of Urology, Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China, Department of Urology, Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou 350025, P.R. China, Department of Pediatric Surgery, Xinhua Hospital, Shanghai 200092, P.R. China, Department of Pathology, Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China
Pages: 767-770
|
Published online on: January 7, 2013

https://doi.org/10.3892/etm.2013.888
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Abstract

The aim of this study was to observe the development and distribution of autogenous nerves in the urinary tract of New Zealand rabbits. Animals of various ages were used in this study, including 2, 3 and 3.5 weeks (gestational ages) and 1, 4, 8 and 12 weeks (postnatal). Samples were selected at various sites of the urinary tract. Immunohistochemical staining methods were used to investigate the nervous plexus and neuroganglia on the wall of the urinary tract. Myenteric plexuses and ganglia first appeared at the gestational age of 3 weeks. They decreased in the pelvis and ureter as the animals developed, until at the end of postnatal week 8, all nerves disappeared completely. However, nerves existed in the bladder and posterior urethra permanently. The development and distribution of myenteric nerves is different between the upper and lower part of the urinary tract. Our study aimed to investigate this further.

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1.	Sişu AM, Petrescu CI, Cebzan CC, et al: Enteric nervous system development in cavitary viscera allocated to the celiac plexus. Rom J Morphol Embryol. 49:63–67. 2008.PubMed/NCBI
2.	Mishalany H, Olson A, Khan F and Santos A: Deficient neurogenic innervation of the myenteric plexus with normal submucous plexus involving the entire small and large bowel. J Pediatr Surg. 24:83–86. 1989. View Article : Google Scholar
3.	Corsois L, Boman F, Sfeir R, et al: Synaptophysin expression abnormalities in Hirschsprung’s disease. Ann Pathol. 24:407–415. 2004.(In French).
4.	Wu XR, Kong XP, Pellicer A, Kreibich G and Sun TT: Uroplakins in urothelial biology, function, and disease. Kidney Int. 75:1153–1165. 2009. View Article : Google Scholar : PubMed/NCBI
5.	Balster S, Schiborr M, Brinkmann OA and Hertle L: Obstructive uropathy in childhood. Aktuelle Urol. 36:317–328. 2005.(In German).
6.	Klahr S: Obstructive nephropathy. Intern Med. 39:355–361. 2000. View Article : Google Scholar
7.	Kubo T and Kawamura S: Anatomy and function of the upper urinary tract. Nihon Hinyokika Gakkai Zasshi. 83:1759–1766. 1992.(In Japanese).
8.	Sugaya K, Nishijima S, Miyazato M and Ogawa Y: Central nervous control of micturition and urine storage. J Smooth Muscle Res. 41:117–132. 2005. View Article : Google Scholar : PubMed/NCBI
9.	Pacary E, Haas MA, Wildner H, et al: Visualization and genetic manipulation of dendrites and spines in the mouse cerebral cortex and hippocampus using in utero electroporation. J Vis Exp. 26:41632012.
10.	Molina-Hernández A, Díaz NF and Arias-Montaño JA: Histamine in brain development. J Neurochem. 122:872–882. 2012.
11.	Burzynski G, Shepherd IT and Enomoto H: Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung’s disease. Neurogastroenterol Motil. 21:113–127. 2009.
12.	Heanue TA and Pachnis V: Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nat Rev Neurosci. 8:466–479. 2007.
13.	Landman KA, Simpson MJ and Newgreen DF: Mathematical and experimental insights into the development of the enteric nervous system and Hirschsprung’s disease. Dev Growth Differ. 49:277–286. 2007.PubMed/NCBI
14.	Sakurai H: Molecular mechanism of ureteric bud development. Semin Cell Dev Biol. 14:217–224. 2003. View Article : Google Scholar : PubMed/NCBI
15.	Körner I: Fetal bladder development. A current overview. Urologe A. 46:1643–1646. 2007.(In German).
16.	Zilberman DE, Golomb J, Kitrey ND, et al: Long-term urinary bladder function following unilateral refluxing low loop cutaneous ureterostomy. Korean J Urol. 53:355–359. 2012. View Article : Google Scholar : PubMed/NCBI
17.	Fujihara A, Ukimura O, Iwata T and Miki T: Neuroselective measure of the current perception threshold of A-delta and C-fiber afferents in the lower urinary tract. Int J Urol. 18:341–349. 2011. View Article : Google Scholar
18.	Yamaguchi O, Honda K, Nomiya M, et al: Defining overactive bladder as hypersensitivity. Neurourol Urodyn. 26:904–907. 2007. View Article : Google Scholar : PubMed/NCBI
19.	Satchell P and Vaughan C: Hypogastric nerve activity to the feline bladder during slow filling. J Auton Nerv Syst. 25:41–47. 1988. View Article : Google Scholar : PubMed/NCBI
20.	Khadra MH, Satchell PM and Vaughan CW: Sympathetic nervous system effects on feline bladder wall compliance throughout continence. Acta Physiol Scand. 155:31–39. 1995. View Article : Google Scholar : PubMed/NCBI
21.	Kuvel M, Canguven O, Murtazaoglu M and Albayrak S: Distribution of Cajal like cells and innervation in intrinsic ureteropelvic junction obstruction. Arch Ital Urol Androl. 83:128–132. 2011.PubMed/NCBI
22.	Waldrop JE: Urinary electrolytes, solutes, and osmolality. Vet Clin North Am Small Anim Pract. 38:503–512. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differences in the development of autogenous nerves between the upper and lower urinary tract

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