Study of the biological effectiveness of a nanosilver‑epidermal growth factor sustained‑release carrier

Zhou,Jian‑Da; Wang,Shao‑Hua; Liu,Rui; Zhou,Chun‑Jiao; Cao,Ke; Liu,Jin‑Yan; Chen,Yao; Chen,Feng‑Hua

doi:10.3892/etm.2013.952

Study of the biological effectiveness of a nanosilver‑epidermal growth factor sustained‑release carrier

Authors:
- Jian‑Da Zhou
- Shao‑Hua Wang
- Rui Liu
- Chun‑Jiao Zhou
- Ke Cao
- Jin‑Yan Liu
- Yao Chen
- Feng‑Hua Chen
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Affiliations: Third Xiang‑Ya Hospital, Central South University, Changsha 410013, P.R. China, Third Xiang‑Ya Hospital, Central South University, Changsha 410013, P.R. China, College of Science, Hunan Agricultural University, Changsha 410128, P.R. China, Xiang‑Ya Hospital, Central South University, Changsha 410008, P.R. China
Published online on: February 6, 2013 https://doi.org/10.3892/etm.2013.952
Pages: 1231-1235

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Abstract

The aim of the present study was to elucidate the biological effectiveness and character of a nanosilver‑epidermal growth factor (EGF) sustained‑release carrier. This was synthesized using the self‑assembly method and then characterized by transmission electron microscopy and UV spectrophotometry. The biological activity of the sustained release carrier was determined through cytological, bacteriological and wound‑healing experiments. The results showed that the nanosilver‑EGF sustained‑release carrier was well dispersed with uniform particle size and that it had good antibacterial properties similar to those of nanosilver. The nanosilver‑EGF sustained‑release carrier is superior to EGFs in effectively promoting cell division and proliferation. The results of the wound‑healing experiments provide evidence of its curative effects.

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