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Article

Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis

  • Authors:
    • Yong Cheng
    • Yan Jiang Wang
    • Jia Chuan Yan
    • Rui Zhou
    • Hua Dong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Daping, Chongqing 400042, P.R. China
  • Pages: 1019-1024
    |
    Published online on: February 8, 2013
       https://doi.org/10.3892/etm.2013.954
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Abstract

Carotid stenosis is known to be an independent risk factor in the transformation process of mild cognitive impairment (MCI) to dementia and is treated by carotid artery stenting (CAS); however, the effects of CAS on cognitive function are unclear. In this study, 240 patients were prospectively assigned to a CAS or control group according to patient preference and underwent detailed neuropsychological examinations (NPEs) before and 6 months after treatment. Cerebral perfusion was assessed with computed tomography perfusion (CTP). Among the 240 patients included in the study, 208 patients completed NPEs at baseline and 6 months after therapy. The patients in the two groups did not differ with regard to baseline characteristics, educational level, vascular risk factors (VRFs) and NPEs prior to therapy. Significant improvements in the Mini-Mental State Examination (MMSE; before, 24.6±1.7 vs. after, 24.8±1.9; P=0.016), Montreal Cognitive Assessment (MOCA; before, 23.7±1.7 vs. after, 24.1±2.0; P=0.006), Fuld Object Memory Evaluation (FOME; before, 13.8±2.2 vs. after, 14.0±2.3; P=0.031) and Wechsler Adult Intelligence Scale-digital span (WAIS-DS; before, 6.7±2.1 vs. after, 6.9±2.3; P=0.040) were observed in the CAS group; however, improvements were not observed in the control group. Of the 84 patients in the CAS group who received CTP follow-up, 72 (86%) presented improvements in ipsilateral brain perfusion 6 months after the procedure; however, no improvement was observed in the control group. Close correlations were identified between the change in perfusion and the change in MMSE (r=0.575) and MOCA (r=0.574). CAS improves global cognitive function in patients with carotid stenosis and MCI and the improvement of cognition is closely related to the improvement of cerebral perfusion.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Wang YJ, Yan JC, Zhou R and Zhou HD: Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis. Exp Ther Med 5: 1019-1024, 2013.
APA
Cheng, Y., Wang, Y.J., Yan, J.C., Zhou, R., & Zhou, H.D. (2013). Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis. Experimental and Therapeutic Medicine, 5, 1019-1024. https://doi.org/10.3892/etm.2013.954
MLA
Cheng, Y., Wang, Y. J., Yan, J. C., Zhou, R., Zhou, H. D."Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis". Experimental and Therapeutic Medicine 5.4 (2013): 1019-1024.
Chicago
Cheng, Y., Wang, Y. J., Yan, J. C., Zhou, R., Zhou, H. D."Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1019-1024. https://doi.org/10.3892/etm.2013.954
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Wang YJ, Yan JC, Zhou R and Zhou HD: Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis. Exp Ther Med 5: 1019-1024, 2013.
APA
Cheng, Y., Wang, Y.J., Yan, J.C., Zhou, R., & Zhou, H.D. (2013). Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis. Experimental and Therapeutic Medicine, 5, 1019-1024. https://doi.org/10.3892/etm.2013.954
MLA
Cheng, Y., Wang, Y. J., Yan, J. C., Zhou, R., Zhou, H. D."Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis". Experimental and Therapeutic Medicine 5.4 (2013): 1019-1024.
Chicago
Cheng, Y., Wang, Y. J., Yan, J. C., Zhou, R., Zhou, H. D."Effects of carotid artery stenting on cognitive function in patients with mild cognitive impairment and carotid stenosis". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1019-1024. https://doi.org/10.3892/etm.2013.954
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