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Article

Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide

  • Authors:
    • Jian Li
    • Fang-Fang Yin
    • Ying-Long Hou
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Qianfo Mountain Hospital Affiliated with Shandong University, Jinan, Shangdong 250014, P.R. China
  • Pages: 1201-1205
    |
    Published online on: February 18, 2013
       https://doi.org/10.3892/etm.2013.964
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Abstract

The aim of this study was to detect early changes (within 1-4 h) in the brain natriuretic peptide (BNP) levels of rats with acute myocardial infarction (AMI). A total of 35 Wistar rats were established as models of AMI and 30 sham‑operated rats were used as the control group. The myocardia of the two groups were observed using a transmission electron microscope (TEM) prior to and following surgery. A double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum BNP and cardiac troponin I (cTnI) concentrations before and 1-4 h after surgery. Following the successful establishment of the AMI models, serum BNP concentrations were significantly increased within 1-4 h compared with the values prior to surgery and with those of the control group (all P<0.01). The serum BNP concentration reached its highest level 2 h after AMI (532.25±15.16 ng/l). No significant changes were observed in the cTnI serum levels of the AMI group within 1-4 h compared with the values before AMI and those in the control group (all P>0.05). In the 1-4 h following the establishment of the AMI model, significant positive correlations were identified between the serum BNP concentrations and the size of the AMI and the most marked correlation occurred 2 h after AMI (r=0.72, P<0.05). No significant differences were noted in the serum concentrations of BNP and cTnI in the control group prior to and following the sham surgery (all P>0.05). BNP may be used as a blood marker for the early diagnosis of AMI, particularly 1-4 h after the onset of AMI, and to predict the size of the infarct area.
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1 

Sudoh T, Kangawa K, Minamino N and Matsuo H: A new natriuretic peptide in porcine brain. Nature. 332:78–81. 1988. View Article : Google Scholar : PubMed/NCBI

2 

de Lamos JA, McGuire DK and Drazner MH: B-type natriuretic peptide in cardiovascular disease. Lancet. 362:316–322. 2003.PubMed/NCBI

3 

Maisel AS, Krishnaswamy P, Nowak RM, et al: Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 347:161–167. 2002. View Article : Google Scholar : PubMed/NCBI

4 

McCullough PA, Nowak RM, McCord J, et al: B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. Circulation. 106:416–422. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Maisel A: B-type natriuretic peptide levels: diagnostic and prognostic incongestive heart failure: what's next? Circulation. 105:2328–2331. 2002.

6 

Mueller C, Scholer A, Laule-Kilian K, et al: Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med. 350:647–654. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Morrow DA, de Lemos JA, Sabatine MS, et al: Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. J Am Coll Cardiol. 41:1264–1272. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Jernberg T, Stridsberg M, Venge P and Lindahl B: N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation. J Am Coll Cardiol. 40:437–445. 2002. View Article : Google Scholar : PubMed/NCBI

9 

de Lemos JA, Morrow DA, Bentley JH, et al: The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med. 345:1014–1021. 2001.

10 

Bettencourt P, Azevedo A, Pimenta J, Friões F, Ferreira S and Ferreira A: N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients. Circulation. 110:2168–74. 2004. View Article : Google Scholar

11 

Hunt SA, Abraham WT, Chin MH, et al: 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 119:e391–e479. 2009.

12 

Cleland JG, McMurray JJ, Kjekshus J, et al: Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure). J Am Coll Cardiol. 54:1850–1859. 2009.

13 

Anderson JL, Adams CD, Antman EM, et al: ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 116:e148–e304. 2007.

14 

Bassan R, Potsch A, Maisel A, et al: B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation. Eur Heart J. 26:234–240. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Morita E, Yasue H, Yoshimura M, et al: Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction. Circulation. 88:82–91. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Haaf P, Reichlin T, Corson N, et al: B-type natriuretic peptide in the early diagnosis and risk stratification of acute chest pain. Am J Med. 124:444–452. 2011. View Article : Google Scholar

17 

Maisel A, Mueller C, Adams K Jr, et al: State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail. 10:824–839. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Sabatine MS, Morrow DA, de Lemos JA, et al: Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. J Am Coll Cardiol. 44:1988–1995. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Staub D, Nusbaumer C, Zellweger MJ, et al: Use of B-type natriuretic peptide in the detection of myocardial ischemia. Am Heart J. 151:1223–1230. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Melanson SE, Morrow DA and Jarolim P: Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity. Am J Clin Pathol. 128:282–286. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Reichlin T, Hochholzer W, Bassetti S, et al: Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 361:858–867. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Ogawa Y, Nakao K, Mukoyama M, et al: Natriuretic peptides as cardiac hormone in normotensive and spontaneously hypertensive rats: the ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Circ Res. 69:491–500. 1991. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Yin F and Hou Y: Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide. Exp Ther Med 5: 1201-1205, 2013.
APA
Li, J., Yin, F., & Hou, Y. (2013). Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide. Experimental and Therapeutic Medicine, 5, 1201-1205. https://doi.org/10.3892/etm.2013.964
MLA
Li, J., Yin, F., Hou, Y."Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide". Experimental and Therapeutic Medicine 5.4 (2013): 1201-1205.
Chicago
Li, J., Yin, F., Hou, Y."Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1201-1205. https://doi.org/10.3892/etm.2013.964
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Yin F and Hou Y: Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide. Exp Ther Med 5: 1201-1205, 2013.
APA
Li, J., Yin, F., & Hou, Y. (2013). Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide. Experimental and Therapeutic Medicine, 5, 1201-1205. https://doi.org/10.3892/etm.2013.964
MLA
Li, J., Yin, F., Hou, Y."Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide". Experimental and Therapeutic Medicine 5.4 (2013): 1201-1205.
Chicago
Li, J., Yin, F., Hou, Y."Early diagnosis of rats with acute myocardial infarction by measurement of brain natriuretic peptide". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1201-1205. https://doi.org/10.3892/etm.2013.964
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