Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study

Martano,Manuela; Navas,Luigi; Meomartino,Leonardo; Abramo,Francesca; Restucci,Brunella; Maiolino,Paola; Lo Muzio,Lorenzo

doi:10.3892/etm.2013.974

Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study

Authors:
- Manuela Martano
- Luigi Navas
- Leonardo Meomartino
- Francesca Abramo
- Brunella Restucci
- Paola Maiolino
- Lorenzo Lo Muzio
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Affiliations: Department of Pathology and Animal Health, Faculty of Biotechnological Sciences, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Veterinary Clinical Science, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Animal Pathology, University of Pisa, Viale delle Piagge 2, Pisa I-56124, Italy, Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Foggia, Foggia I-71121, Italy
Published online on: February 25, 2013 https://doi.org/10.3892/etm.2013.974
Pages: 1005-1008

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Abstract

An eleven year-old mongrel dog was referred with a history of left forelimb lameness and an ulcerated mass on the neck. Histologically, the cutaneous neoplasm revealed cystic lobules composed of basaloid cells with abrupt transition to central keratotic material, containing pycnotic and shadow cells. Approximately 3 months after primary diagnosis, a lesion of the cortical bone on the left humerus was observed using X-ray. Samples obtained from the humerus were processed for histopathological examination and the neoplastic tissue was observed to be similar to the type identified in the neck. Based on these findings, the tumor was diagnosed as a malignant pilomatricoma (MP) with bone metastasis. MP is a rare skin tumor that originates from hair matrix cells. To date, only nine reports have been presented in dogs. In the present study, we discuss the cytological and histological patterns of MP, confirmed by immunohistochemistry using β catenin antibody.

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1	Stannard AA and Pulley LT: Tumours of the skin and soft tissues. Tumors in Domestic Animals. Moulton JE: 2nd edition. University of California Press; Los Angeles: pp. 511978
2	Gould E, Kurzon R, Kowalczyk AP and Saldana M: Pilomatrix carcinoma with pulmonary metastasis. Report of a case. Cancer. 54:370–372. 1984. View Article : Google Scholar : PubMed/NCBI
3	Walders E and Gross TL: Neoplastic disease of the skin. Veterinary Dermatopathology: A Macroscopic and Microscopic Evaluation of Canine and Feline Skin Disease. Gross TL, Ihrke PJ and Walder EJ: 2nd edition. Mosby; St. Louis: pp. 365–367. 1992
4	Niedermeyer HP, Peris K and Höfler H: Pilomatrix carcinoma with multiple visceral metastases. Report of a case. Cancer. 77:1311–1314. 1996. View Article : Google Scholar : PubMed/NCBI
5	McKee P: Essential Skin Pathology. 2nd edition. Mosby, International Ltd; London: 1999
6	Abramo F, Pratesi F, Cantile C, Sozzi S and Poli A: Survey of canine and feline follicular tumours and tumour-like lesions in central Italy. J Small Anim Pract. 40:479–481. 1999. View Article : Google Scholar : PubMed/NCBI
7	Goldschmidt MH and Hendrick MJ: Tumors of the skin and soft tissues. Tumors in Domestic Animals. Meuten DJ: 4th edition. Iowa State Press; Ames: pp. 61–63. 2002
8	Goldschmidt MH and Shofer FS: Skin Tumours of the Dog and Cat. 1st edition. Pergamon Press; Oxford: 1992
9	Pakhrin B, Kang MS, Bae IH, et al: Retrospective study of canine cutaneous tumors in Korea. J Vet Sci. 8:229–236. 2007. View Article : Google Scholar : PubMed/NCBI
10	Sells DM and Conroy JD: Malignant epithelial neoplasia with hair follicle differentiation in dogs. Malignant pilomatrixoma. J Comp Pathol. 86:121–129. 1976. View Article : Google Scholar : PubMed/NCBI
11	Goldschmidt MH, Thrall DE, Jeglum KA, Everett JI and Wood MG: Malignant pilomatricoma in a dog. J Cutan Pathol. 8:375–381. 1981. View Article : Google Scholar
12	Johnson RP, Johnson JA, Groom SC and Burgess L: Malignant pilomatrixoma in an old english sheepdog. Can Vet J. 24:392–394. 1983.PubMed/NCBI
13	Rodriguez F, Herraez P, Rodriguez E, Gomez-Villamandos JC and Espinosa de los Monteros A: Metastatic pilomatrixoma associated with neurological signs in a dog. Vet Rec. 137:247–248. 1995. View Article : Google Scholar : PubMed/NCBI
14	Jackson K, Boger L, Goldschmidt M and Walton RM: Malignant pilomatricoma in a soft-coated Wheaten Terrier. Vet Clin Pathol. 39:236–240. 2010. View Article : Google Scholar : PubMed/NCBI
15	Carroll EE, Fossey SL, Mangus LM, et al: Malignant pilomatricoma in 3 dogs. Vet Pathol. 47:937–943. 2010. View Article : Google Scholar : PubMed/NCBI
16	Van Ham L, van Bree H, Maenhout T, et al: Metastatic pilomatrixoma presenting as paraplegia in a dog. J Small Anim Pract. 32:27–30. 1991.
17	Huzella L, Ide A, Steinbach TJ, Blanchard TW, Lipscomb TP and Schulman FY: Osteosarcoma in malignant pilomatricoma. Vet Pathol. 42:7002005.
18	Morin PJ, Sparks AB, Korinek V, et al: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 275:1787–1790. 1997. View Article : Google Scholar : PubMed/NCBI
19	Barth AI, Näthke IS and Nelson WJ: Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol. 9:683–690. 1997. View Article : Google Scholar : PubMed/NCBI
20	Chan EF, Gat U, McNiff JM and Fuchs E: A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet. 21:410–413. 1999. View Article : Google Scholar : PubMed/NCBI
21	Xia J, Urabe K, Moroi Y, et al: beta-Catenin mutation and its nuclear localization are confirmed to be frequent causes of Wnt signaling pathway activation in pilomatricomas. J Dermatol Sci. 41:67–75. 2006. View Article : Google Scholar : PubMed/NCBI
22	Moreno-Bueno G, Gamallo C, Pérez-Gallego L, Contreras F and Palacios J: beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles. Br J Dermatol. 145:576–581. 2001. View Article : Google Scholar : PubMed/NCBI