Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study

Martano,Manuela; Navas,Luigi; Meomartino,Leonardo; Abramo,Francesca; Restucci,Brunella; Maiolino,Paola; Lo Muzio,Lorenzo

doi:10.3892/etm.2013.974

April 2013 Volume 5 Issue 4

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April 2013 Volume 5 Issue 4

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Article

Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study

Authors:
- Manuela Martano
- Luigi Navas
- Leonardo Meomartino
- Francesca Abramo
- Brunella Restucci
- Paola Maiolino
- Lorenzo Lo Muzio
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Affiliations: Department of Pathology and Animal Health, Faculty of Biotechnological Sciences, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Veterinary Clinical Science, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Animal Pathology, University of Pisa, Viale delle Piagge 2, Pisa I-56124, Italy, Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University Federico II -Via Delpino, Naples I-80137, Italy, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Foggia, Foggia I-71121, Italy
Pages: 1005-1008
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Published online on: February 25, 2013

https://doi.org/10.3892/etm.2013.974
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Abstract

An eleven year-old mongrel dog was referred with a history of left forelimb lameness and an ulcerated mass on the neck. Histologically, the cutaneous neoplasm revealed cystic lobules composed of basaloid cells with abrupt transition to central keratotic material, containing pycnotic and shadow cells. Approximately 3 months after primary diagnosis, a lesion of the cortical bone on the left humerus was observed using X-ray. Samples obtained from the humerus were processed for histopathological examination and the neoplastic tissue was observed to be similar to the type identified in the neck. Based on these findings, the tumor was diagnosed as a malignant pilomatricoma (MP) with bone metastasis. MP is a rare skin tumor that originates from hair matrix cells. To date, only nine reports have been presented in dogs. In the present study, we discuss the cytological and histological patterns of MP, confirmed by immunohistochemistry using β catenin antibody.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study

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