Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema

  • Authors:
    • Mingdong Gao
    • Ruimin Wang
    • Zepei Jiayong
    • Yin Liu
    • Genyi Sun
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tianjin Chest Hospital, Tianjin 30051, P.R. China, Department of Clinical Laboratory, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China, Changdu District People's Hospital, Tibet 854000, P.R. China
  • Pages: 1434-1438
    |
    Published online on: February 26, 2013
       https://doi.org/10.3892/etm.2013.976
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of B‑type natriuretic peptides (BNPs) in acute high‑altitude pulmonary edema (HAPE). The study enrolled 46 subjects from lowland Han, including 33 individuals who had acutely ascended to a high altitude (21 individuals with HAPE as the case group and 12 individuals without HAPE as the high‑altitude control group) and 13 healthy normal residents as the plain control group. The serum concentrations of N-terminal probrain natriuretic peptide (NT‑proBNP), erythropoietin (EPO), vascular endothelial growth factor (VEGF) and nitric oxide (NO) were measured. There were significant differences in the serum concentrations of NT‑ProBNP, NO, VEGF and EPO among the three groups. The serum concentrations of NT‑ProBNP, EPO and VEGF were significantly higher in the HAPE patients and high‑altitude control individuals than those of the plain group. No significant differences were identified between the HAPE patients and the high‑altitude control group. In contrast to these three parameters, the serum concentrations of NO in the high‑altitude control group were significantly higher than those of the HAPE patients and the plain group, while there were no significant differences in the serum concentrations of NO between the HAPE patients and the plain group. Furthermore, serum concentrations of NT‑ProBNP and EPO were significantly reduced following treatment in the HAPE patients, however, no significant changes were identified in VEGF or NO concentrations. BNPs are increased in HAPE with severe hypoxia and right ventricular overload, but are decreased subsequent to treatment. BNPs may therefore be a potential biomarker for the diagnosis and prognosis of HAPE.
View Figures
View References

1. 

Scherrer U, Rexhaj E, Jayet PY, Allemann Y and Sartori C: New insights in the pathogenesis of high-altitude pulmonary edema. Prog Cardiovasc Dis. 52:485–492. 2010. View Article : Google Scholar : PubMed/NCBI

2. 

Duplain H, Vollenweider L, Delabays A, Nicod P, Bärtsch P and Scherrer U: Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation. 99:1713–1718. 1999. View Article : Google Scholar : PubMed/NCBI

3. 

Duplain H, Sartori C, Lepori M, et al: Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am J Respir Crit Care Med. 162:221–224. 2000. View Article : Google Scholar : PubMed/NCBI

4. 

Bailey DM, Dehnert C, Luks AM, et al: High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability. J Physiol. 588:4837–4847. 2010. View Article : Google Scholar : PubMed/NCBI

5. 

Pham I, Wuerzner G, Richalet JP, et al: Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans. Eur J Clin Invest. 40:195–202. 2010. View Article : Google Scholar : PubMed/NCBI

6. 

Sartori C, Vollenweider L, Löffler BM, et al: Exaggerated endothelin release in high-altitude pulmonary edema. Circulation. 99:2665–2668. 1999. View Article : Google Scholar : PubMed/NCBI

7. 

Christou H, Yoshida A, Arthur V, Morita T and Kourembanas S: Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 18:768–776. 1998. View Article : Google Scholar : PubMed/NCBI

8. 

Nakanishi K, Tajima F, Itoh H, et al: Changes in atrial natriuretic peptide and brain natriuretic peptide associated with hypobaric hypoxia induced pulmonary hypertension in rats. Virchows Arch. 439:808–817. 2001. View Article : Google Scholar : PubMed/NCBI

9. 

Weidemann A, Klanke B, Wagner M, et al: Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction. Biochem J. 409:233–242. 2008. View Article : Google Scholar : PubMed/NCBI

10. 

Klinger JR, Thaker S, Houtchens J, Preston IR, Hill NS and Farber HW: Pulmonary hemodynamic responses to brain natriuretic peptide and sildenafil in patients with pulmonary arterial hypertension. Chest. 129:417–425. 2006. View Article : Google Scholar : PubMed/NCBI

11. 

McGrath MF, de Bold ML and de Bold AJ: The endocrine function of the heart. Trends Endocrinol Metab. 16:469–477. 2005. View Article : Google Scholar : PubMed/NCBI

12. 

Kishimoto I, Tokudome T, Horio T, Garbers DL, Nakao K and Kangawa K: Natriuretic peptide signaling via guanylyl cyclase (GC)-A: an endogenous protective mechanism of the heart. Curr Cardiol Rev. 5:45–51. 2009. View Article : Google Scholar : PubMed/NCBI

13. 

Hackett PH and Oelz O: The Lake Louise consensus on the definition and quantification of altitude illness. Mountain Medicine Hypoxia. Sutton JR, Houston CS and Coates G: VT: Queen City Printers; Burlington: pp. 327–330. 1992

14. 

Ge RL, Mo VY, Januzzi JL, et al: B-type natriuretic peptide, vascular endothelial growth factor, endothelin-1, and nitric oxide synthase in chronic mountain sickness. Am J Physiol Heart Circ Physiol. 300:H1427–H1433. 2011. View Article : Google Scholar : PubMed/NCBI

15. 

Palazzuoli A, Calabria P, Vecchiato L, et al: Plasma brain natriuretic peptide levels in coronary heart disease with preserved systolic function. Clin Exp Med. 4:44–49. 2004. View Article : Google Scholar : PubMed/NCBI

16. 

Casals G, Ros J, Sionis A, Davidson MM, Morales-Ruiz M and Jiménez W: Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes. Am J Physiol Heart Circ Physiol. 297:H550–H555. 2009. View Article : Google Scholar : PubMed/NCBI

17. 

Xia WJ, Huang YY, Chen YL, Chen SL and He JG: Acute myocardial ischemia directly modulates the expression of brain natriuretic peptide at the transcriptional and translational levels via inflammatory cytokines. Eur J Pharmacol. 670:7–12. 2011. View Article : Google Scholar

18. 

Lemus-Varela ML, Flores-Soto ME, Cervantes-Munguía R, et al: Expression of HIF-1 alpha, VEGF and EPO in peripheral blood from patients with two cardiac abnormalities associated with hypoxia. Clin Biochem. 43:234–239. 2010. View Article : Google Scholar : PubMed/NCBI

19. 

Steiner J and Guglin M: BNP or NT-proBNP? A clinician’s perspective. Int J Cardiol. 129:5–14. 2008.

20. 

Kaufmann BA, Bernheim AM, Kiencke S, et al: Evidence supportive of impaired myocardial blood flow reserve at high-altitude in subjects developing high-altitude pulmonary edema. Am J Physiol Heart Circ Physiol. 294:H1651–H1657. 2008. View Article : Google Scholar : PubMed/NCBI

21. 

Mahmud E, Raisinghani A, Hassankhani A, et al: Correlation of left ventricular diastolic filling characteristics with right ventricular overload and pulmonary artery pressure in chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol. 40:318–324. 2002. View Article : Google Scholar

22. 

Allemann Y, Rotter M, Hutter D, et al: Impact of acute hypoxic pulmonary hypertension on LV diastolic function in healthy mountaineers at high altitude. Am J Physiol Heart Circ Physiol. 286:H856–H862. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Mason NP, Petersen M, Melot C, et al: Serial changes in nasal potential difference and lung electrical impedance tomography at high-altitude. J Appl Physiol. 94:2043–2050. 2003. View Article : Google Scholar : PubMed/NCBI

24. 

Toshner MR, Thompson AA, Irving JB, et al: NT-proBNP does not rise on acute ascent to high-altitude. High Alt Med Biol. 9:307–310. 2008. View Article : Google Scholar : PubMed/NCBI

25. 

Feddersen B, Ausserer H, Haditsch B, Frisch H, Noachtar S and Straube A: Brain natriuretic peptide at altitude: relationship to diuresis, natriuresis, and mountain sickness. Aviat Space Environ Med. 80:108–111. 2009. View Article : Google Scholar : PubMed/NCBI

26. 

Woods D, Hooper T, Hodkinson P, et al: Effects of altitude exposure on brain natriuretic peptide in humans. Eur J Appl Physiol. 111:2687–2693. 2011. View Article : Google Scholar : PubMed/NCBI

27. 

Woods DR, Begley J, Stacey M, Smith C, Boos CJ, Hooper T, Hawkins A, Hodkinson P, Green N and Mellor A: Severe acute mountain sickness, brain natriuretic peptide and NT-proBNP in humans. Acta Physiol (Oxf). 205:349–355. 2012. View Article : Google Scholar : PubMed/NCBI

28. 

Yoshimura M, Yasue H and Ogawa H: Pathophysiological significance and clinical application of ANP and BNP in patients with heart failure. Can J Physiol Pharmacol. 79:730–735. 2001. View Article : Google Scholar : PubMed/NCBI

29. 

Leuchte HH, Holzapfel M, Baumgartner RA, Neurohr C, Vogeser M and Behr J: Characterization of brain natriuretic peptide in long-term follow-up of pulmonary arterial hypertension. Chest. 128:2368–2374. 2005. View Article : Google Scholar : PubMed/NCBI

30. 

McGrath MF, de Bold ML and de Bold AJ: The endocrine function of the heart. Trends Endocrinol Metab. 16:469–477. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao M, Wang R, Jiayong Z, Liu Y and Sun G: NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema. Exp Ther Med 5: 1434-1438, 2013.
APA
Gao, M., Wang, R., Jiayong, Z., Liu, Y., & Sun, G. (2013). NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema. Experimental and Therapeutic Medicine, 5, 1434-1438. https://doi.org/10.3892/etm.2013.976
MLA
Gao, M., Wang, R., Jiayong, Z., Liu, Y., Sun, G."NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema". Experimental and Therapeutic Medicine 5.5 (2013): 1434-1438.
Chicago
Gao, M., Wang, R., Jiayong, Z., Liu, Y., Sun, G."NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1434-1438. https://doi.org/10.3892/etm.2013.976
Copy and paste a formatted citation
x
Spandidos Publications style
Gao M, Wang R, Jiayong Z, Liu Y and Sun G: NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema. Exp Ther Med 5: 1434-1438, 2013.
APA
Gao, M., Wang, R., Jiayong, Z., Liu, Y., & Sun, G. (2013). NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema. Experimental and Therapeutic Medicine, 5, 1434-1438. https://doi.org/10.3892/etm.2013.976
MLA
Gao, M., Wang, R., Jiayong, Z., Liu, Y., Sun, G."NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema". Experimental and Therapeutic Medicine 5.5 (2013): 1434-1438.
Chicago
Gao, M., Wang, R., Jiayong, Z., Liu, Y., Sun, G."NT‑ProBNP levels are moderately increased in acute high‑altitude pulmonary edema". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1434-1438. https://doi.org/10.3892/etm.2013.976
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team