The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction

Wang,Zhong-Ming; Liu,Ya-Bing; Jin,Qi-Chen; Wang,Xue-Qi; Dai,Meng; Shao,Hui; Zhao,Wen-Ping; Dong,Qiu-Li; Wang,Shu-Ping; Zhang,Hai-Tao; Kong,Li-Cha; Liu,Shao-Yun; Wang,Dong-Ying

doi:10.3892/etm.2013.980

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Article

The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction

Authors:
- Zhong-Ming Wang
- Ya-Bing Liu
- Qi-Chen Jin
- Xue-Qi Wang
- Meng Dai
- Hui Shao
- Wen-Ping Zhao
- Qiu-Li Dong
- Shu-Ping Wang
- Hai-Tao Zhang
- Li-Cha Kong
- Shao-Yun Liu
- Dong-Ying Wang
View Affiliations / Copyright

Affiliations: Second Department of Cardiology, General Hospital of North China Petroleum Administration, Renqiu, Hebei 062552, P.R. China, Department of Internal Medicine, Jingxia Hospital of North China Petroleum Administration, Renqiu, Hebei 062552, P.R. China, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Department of Science and Technology, Jingxia Hospital of North China Petroleum Administration, Renqiu, Hebei 062552, P.R. China, Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China, Department of Radiology, Jingxia Hospital of North China Petroleum Administration, Renqiu, Hebei 062552, P.R. China
Pages: 1363-1366
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Published online on: February 27, 2013

https://doi.org/10.3892/etm.2013.980
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Abstract

The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01‑06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P<0.05). The level of plasminogen activator inhibitor-1 (PAI-1) antigen was significantly higher in the morning onset group compared with that in the non-morning onset group (P<0.05). This indicated a resistance to r-SK thrombolysis in the morning at the early stage of AMI, which possibly correlates with increased PAI-1 antigen levels and activity.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction

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