Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Cardiac stem cells in patients with heart disease (Review)

  • Authors:
    • Xiaohui Zhao
    • Lan Huang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 1273-1276
    |
    Published online on: February 28, 2013
       https://doi.org/10.3892/etm.2013.984
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The heart has been regarded as a terminally differentiated organ for decades. There are numerous indicators for the potency of myocardial regeneration, which opens up new avenues for the treatment of heart disease. Cardiac stem cells (CSCs) have been discovered in the human heart and they play a vital role in myocardial regeneration. This review discusses the distribution, properties and proliferation of CSCs in the myocardium of patients with heart disease. Additionally, the potency of myocardial regeneration in patients with heart disease is discussed.
View Figures

Figure 1

Figure 2

View References

1. 

Nakamura T and Schneider MD: The way to a human’s heart is through the stomach: visceral endoderm-like cells drive human embryonic stem cells to a cardiac fate. Circulation. 107:2638–2639. 2003.

2. 

Kajstura J, Leri A, Castaldo C, et al: Myocyte growth in the failing heart. Surg Clin North Am. 84:161–177. 2004. View Article : Google Scholar

3. 

Beltrami AP, Urbanek K, Kajstura J, et al: Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 344:1750–1757. 2001. View Article : Google Scholar : PubMed/NCBI

4. 

Anversa P, Kajstura J, Leri A, et al: Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation. 113:1451–1463. 2006. View Article : Google Scholar : PubMed/NCBI

5. 

Beltrami AP, Barlucchi L, Torella D, et al: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 114:763–776. 2003. View Article : Google Scholar : PubMed/NCBI

6. 

Laugwitz KL, Moretti A, Lam J, et al: Postnatal isl1+ cardio-blasts enter fully differentiated cardiomyocyte lineages. Nature. 433:647–653. 2005.

7. 

Anversa P, Leri A, Kajstura J, et al: Myocyte growth and cardiac repair. J Mol Cell Cardiol. 34:91–105. 2002. View Article : Google Scholar

8. 

Hierlihy AM, Seale P, Lobe CG, et al: The post-natal heart contains a myocardial stem cell population. FEBS Lett. 530:239–243. 2002. View Article : Google Scholar : PubMed/NCBI

9. 

Matsuura K, Nagai T, Nishigaki N, et al: Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem. 279:11384–11391. 2004. View Article : Google Scholar : PubMed/NCBI

10. 

Nadal-Ginard B, Kajstura J, Leri A, et al: Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res. 92:139–150. 2003. View Article : Google Scholar : PubMed/NCBI

11. 

Oh H, Bradfute SB, Gallardo TD, et al: Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA. 100:12313–12318. 2003. View Article : Google Scholar : PubMed/NCBI

12. 

Quaini F, Urbanek K, Beltrami AP, et al: Chimerism of the transplanted heart. N Engl J Med. 346:5–15. 2002. View Article : Google Scholar : PubMed/NCBI

13. 

Urbanek K, Quaini F, Tasca G, et al: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA. 100:10440–10445. 2003. View Article : Google Scholar : PubMed/NCBI

14. 

Leri A, Kajstura J and Anversa P: Myocyte proliferation and ventricular remodeling. J Card Fail. 8:S518–S525. 2002. View Article : Google Scholar : PubMed/NCBI

15. 

Smith RR, Barile L, Cho HC, et al: Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 115:896–908. 2007. View Article : Google Scholar : PubMed/NCBI

16. 

Linke A, Muller P, Nurzynska D, et al: Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci USA. 102:8966–8971. 2005. View Article : Google Scholar

17. 

Pouly J, Bruneval P, Mandet C, et al: Cardiac stem cells in the real world. J Thorac Cardiovasc Surg. 135:673–678. 2008. View Article : Google Scholar : PubMed/NCBI

18. 

Dawn B, Stein AB, Urbanek K, et al: Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci USA. 102:3766–3771. 2005. View Article : Google Scholar

19. 

Urbanek K, Torella D, Sheikh F, et al: Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA. 102:8692–8697. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Wagers AJ, Christensen JL and Weissman IL: Cell fate determination from stem cells. Gene Ther. 9:606–612. 2002. View Article : Google Scholar : PubMed/NCBI

21. 

Tsuura Y, Hiraki H, Watanabe K, et al: Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch. 424:135–141. 1994. View Article : Google Scholar

22. 

Messina E, De Angelis L, Frati G, et al: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res. 95:911–921. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Chimenti C, Kajstura J, Torella D, et al: Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res. 93:604–613. 2003. View Article : Google Scholar : PubMed/NCBI

24. 

Weissman IL: Stem cells: units of development, units of regeneration, and units in evolution. Cell. 100:157–168. 2000. View Article : Google Scholar : PubMed/NCBI

25. 

Rosenblatt-Velin N, Lepore MG, Cartoni C, et al: FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest. 115:1724–1733. 2005. View Article : Google Scholar : PubMed/NCBI

26. 

Kajstura J, Leri A, Finato N, et al: Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA. 95:8801–8805. 1998. View Article : Google Scholar : PubMed/NCBI

27. 

McConnell BB, Starborg M, Brookes S, et al: Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol. 8:351–354. 1998. View Article : Google Scholar

28. 

Hara E, Smith R, Parry D, et al: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 16:859–867. 1996.PubMed/NCBI

29. 

Kim K, Lee KM, Han DJ, et al: Adult stem cell-like tubular cells reside in the corticomedullary junction of the kidney. Int J Clin Exp Pathol. 1:232–241. 2008.PubMed/NCBI

30. 

Daniel WG, Baumgartner H, Gohlke-Barwolf C, et al: Aortic stenosis. Clin Res Cardiol. 95:620–641. 2006.(In German).

31. 

Nadin BM, Goodell MA and Hirschi KK: Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood. 102:2436–2443. 2003. View Article : Google Scholar : PubMed/NCBI

32. 

Carabello BA and Crawford FA Jr: Valvular heart disease. N Engl J Med. 337:32–41. 1997. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X and Huang L: Cardiac stem cells in patients with heart disease (Review). Exp Ther Med 5: 1273-1276, 2013.
APA
Zhao, X., & Huang, L. (2013). Cardiac stem cells in patients with heart disease (Review). Experimental and Therapeutic Medicine, 5, 1273-1276. https://doi.org/10.3892/etm.2013.984
MLA
Zhao, X., Huang, L."Cardiac stem cells in patients with heart disease (Review)". Experimental and Therapeutic Medicine 5.5 (2013): 1273-1276.
Chicago
Zhao, X., Huang, L."Cardiac stem cells in patients with heart disease (Review)". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1273-1276. https://doi.org/10.3892/etm.2013.984
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X and Huang L: Cardiac stem cells in patients with heart disease (Review). Exp Ther Med 5: 1273-1276, 2013.
APA
Zhao, X., & Huang, L. (2013). Cardiac stem cells in patients with heart disease (Review). Experimental and Therapeutic Medicine, 5, 1273-1276. https://doi.org/10.3892/etm.2013.984
MLA
Zhao, X., Huang, L."Cardiac stem cells in patients with heart disease (Review)". Experimental and Therapeutic Medicine 5.5 (2013): 1273-1276.
Chicago
Zhao, X., Huang, L."Cardiac stem cells in patients with heart disease (Review)". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1273-1276. https://doi.org/10.3892/etm.2013.984
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team