Study on potential role of apolipoprotein E in recurrent pregnancy loss

Korkmazer,Engin; Ustunyurt,Emın; Tekin,Başar; Cilingir,Oguz

doi:10.3892/etm.2013.997

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Article

Study on potential role of apolipoprotein E in recurrent pregnancy loss

Authors:
- Engin Korkmazer
- Emın Ustunyurt
- Başar Tekin
- Oguz Cilingir
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Faculty of Medicine, Eskişehir Osmangazi University, Eskisehir, Turkey, Department of Obstetrics and Gynecology, Bursa Şevket Yılmaz Research and Education Hospital, Bursa, Turkey, Department of Medical Genetics, Eskişehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey
Pages: 1408-1410
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Published online on: March 11, 2013

https://doi.org/10.3892/etm.2013.997
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Abstract

The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their Apo E genotypes, based on restriction fragment length polymorphism analysis of polymerase chain reaction (PCR)-amplified fragments. The observed genotypes were compared with those obtained from equal number matched controls. We observed similar Apo E genotypes and E2, E3 and E4 allele frequency distribution among RPL patients and controls. The allele frequencies obtained in patients and controls, respectively, were as follows: E2=8 (9%) and 12 (13.4%) (P=0.342), E3=66 (73.3%) and 60 (66.6%) (P=0.328) and E4=16 (17.7%) and 18 (20%) (P=0.703). Our data did not support the association of Apo E gene polymorphisms with RPL as reported by previous studies. We endorse adequate characterization of RPL cases and adequate sample size prior to addressing such studies.

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