Association between the ‑112G/A polymorphism of uteroglobulin‑related protein 1 gene and asthma risk: A meta‑analysis

Xie,Haojun; Wu,Muli; Shen,Bin; Niu,Yi; Huo,Yating; Cheng,Yuanxiong

doi:10.3892/etm.2014.1471

Association between the ‑112G/A polymorphism of uteroglobulin‑related protein 1 gene and asthma risk: A meta‑analysis

Authors:
- Haojun Xie
- Muli Wu
- Bin Shen
- Yi Niu
- Yating Huo
- Yuanxiong Cheng
View Affiliations

Affiliations: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: January 2, 2014 https://doi.org/10.3892/etm.2014.1471
Pages: 721-727

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of this study was to investigate the correlation between the ‑112G/A polymorphism of the uteroglobulin‑related protein 1 (UGRP1) gene and asthma risk using meta‑analysis. PubMed, BIOSIS Previews and EBSCOhost were searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using Review Manager 5.2 and STATA 11.0 software. Six studies, involving 816 cases and 1,165 controls, were included in the analysis. The meta‑analysis showed a significant correlation between the UGRP1‑112G/A polymorphism and asthma for AA versus GG (P=0.01) and AA versus GA/GG (P=0.02). Furthermore, stratification by ethnicity revealed a significant correlation between the ‑112G/A polymorphism and asthma for A versus G (P=0.02), AA versus GG (P=0.01) and AA versus GA/GG (P=0.03) in Asians, but not in Caucasians. When stratified by atopy, a significant correlation was observed for A versus G (P=0.02) and AA/GA versus GG (P=0.04) in the mixed group. No correlation was observed for age stratification. Results of the current meta‑analysis indicate that the ‑112G/A polymorphism of the UGRP1 gene is likely to contribute to asthma risk, particularly in the Asian population.

View Figures

View References

1	Masoli M, Fabian D, Holt S and Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 59:469–478. 2004. View Article : Google Scholar : PubMed/NCBI
2	Mukherjee AB and Zhang Z: Allergic asthma: influence of genetic and environmental factors. J Biol Chem. 286:32883–32889. 2011. View Article : Google Scholar : PubMed/NCBI
3	Vercelli D: Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 8:169–182. 2008. View Article : Google Scholar : PubMed/NCBI
4	Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC and Kimura S: UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Mol Endocrinol. 15:2021–2036. 2001. View Article : Google Scholar
5	Niimi T, Munakata M, Keck-Waggoner CL, et al: A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. Am J Hum Genet. 70:718–725. 2002. View Article : Google Scholar : PubMed/NCBI
6	Singh G and Katyal SL: Clara cells and Clara cell 10 kD protein (CC10). Am J Respir Cell Mol Biol. 17:141–143. 1997. View Article : Google Scholar : PubMed/NCBI
7	Inoue K, Wang X, Saito J, et al: Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. Allergol Int. 57:57–64. 2008. View Article : Google Scholar : PubMed/NCBI
8	Heinzmann A, Dietrich H and Deichmann KA: Association of uteroglobulin-related protein 1 with bronchial asthma. Int Arch Allergy Immunol. 131:291–295. 2003. View Article : Google Scholar : PubMed/NCBI
9	Jian Z, Nakayama J, Noguchi E, Shibasaki M and Arinami T: No evidence for association between the -112G/A polymorphism of UGRP1 and childhood atopic asthma. Clin Exp Allergy. 33:902–904. 2003. View Article : Google Scholar : PubMed/NCBI
10	Rigoli L, Di Bella C, Procopio V, et al: Uteroglobin-related protein 1 gene -112G/a polymorphism and atopic asthma in Sicilian children. Allergy Asthma Proc. 28:667–670. 2007. View Article : Google Scholar : PubMed/NCBI
11	Batra J, Niphadkar PV, Sharma SK and Ghosh B: Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. Int Arch Allergy Immunol. 136:1–6. 2005. View Article : Google Scholar : PubMed/NCBI
12	Andiappan AK, Yeo WS, Parate PN, et al: Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese. BMC Med Genet. 12:392011. View Article : Google Scholar : PubMed/NCBI
13	Thakkinstian A, McEvoy M, Minelli C, et al: Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol. 162:201–211. 2005.
14	Hyun MH, Lee CH, Kang MH, Park BK and Lee YH: Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis. PLoS One. 8:e537582013. View Article : Google Scholar : PubMed/NCBI
15	Koppelman GH: Gene by environment interaction in asthma. Curr Allergy Asthma Rep. 6:103–111. 2006. View Article : Google Scholar : PubMed/NCBI
16	Arsalane K, Broeckaert F, Knoops B, Wiedig M, Toubeau G and Bernard A: Clara cell specific protein (CC16) expression after acute lung inflammation induced by intratracheal lipopolysaccharide administration. Am J Respir Crit Care Med. 161:1624–1630. 2000. View Article : Google Scholar
17	Chistiakov DA, Voronova NV, Turakulov RI and Savost’Anov KV: The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves’ disease in subsets of patients with elevated levels of immunoglobulin E. J Appl Genet. 52:201–207. 2011.
18	Song HD, Liang J, Shi JY, et al: Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves’ disease. Hum Mol Genet. 18:1156–1170. 2009.PubMed/NCBI
19	de Burbure C, Pignatti P, Corradi M, et al: Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. Chest. 131:172–179. 2007.PubMed/NCBI