Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma

  • Authors:
    • Qing‑Jiu Ma
    • Yu‑Cun Zhang
    • Jing‑Sen Shi
    • Guo‑Cai Li
  • View Affiliations

  • Published online on: January 2, 2014     https://doi.org/10.3892/etm.2014.1472
  • Pages: 635-639
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Abstract

P‑glycoprotein (P‑gp) and glutathione S‑transferase π (GST‑π) are not only drug‑resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P‑gp and GST‑π in gallbladder carcinoma (GBC). Tissue samples from 42 patients with GBC were immunostained. Demographic, clinical and follow‑up data were collected and analyzed. The positive expression rates of P‑gp and GST‑π in the GBC tissues were significantly higher (76.2 and 64.3%, respectively) than that of chronic cholecystitis specimens (30 and 20%, respectively) (P=0.014 and 0.035, respectively), and correlated with the Nevin stage of GBC. Multivariate analysis demonstrated that patients with positive expression of P‑gp and GST‑π showed a significantly lower 2‑year survival rate (11.1 and 12%, respectively) compared with patients with negative expression (55.6 and 45.5%, respectively) (P=0.013 and 0.036, respectively). P‑gp was also found to be an independent prognostic marker of 2‑year survival rate by logistic regression analysis (B=‑2.76, P=0.061). Results of this study suggest that P‑gp is a prognostic marker of GBC and the detection of P‑gp and GST‑π may contribute to the prognosis of GBC and the application of chemotherapy as a therapeutic treatment.
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2014-March
Volume 7 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ma QJ, Zhang YC, Shi JS and Li GC: Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Exp Ther Med 7: 635-639, 2014
APA
Ma, Q., Zhang, Y., Shi, J., & Li, G. (2014). Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Experimental and Therapeutic Medicine, 7, 635-639. https://doi.org/10.3892/etm.2014.1472
MLA
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7.3 (2014): 635-639.
Chicago
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7, no. 3 (2014): 635-639. https://doi.org/10.3892/etm.2014.1472