Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma

  • Authors:
    • Qing‑Jiu Ma
    • Yu‑Cun Zhang
    • Jing‑Sen Shi
    • Guo‑Cai Li
  • View Affiliations / Copyright

    Affiliations: General Surgery Department, GaoXin Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710075, P.R. China, Hepatobiliary Department, First Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 635-639
    |
    Published online on: January 2, 2014
       https://doi.org/10.3892/etm.2014.1472
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

P‑glycoprotein (P‑gp) and glutathione S‑transferase π (GST‑π) are not only drug‑resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P‑gp and GST‑π in gallbladder carcinoma (GBC). Tissue samples from 42 patients with GBC were immunostained. Demographic, clinical and follow‑up data were collected and analyzed. The positive expression rates of P‑gp and GST‑π in the GBC tissues were significantly higher (76.2 and 64.3%, respectively) than that of chronic cholecystitis specimens (30 and 20%, respectively) (P=0.014 and 0.035, respectively), and correlated with the Nevin stage of GBC. Multivariate analysis demonstrated that patients with positive expression of P‑gp and GST‑π showed a significantly lower 2‑year survival rate (11.1 and 12%, respectively) compared with patients with negative expression (55.6 and 45.5%, respectively) (P=0.013 and 0.036, respectively). P‑gp was also found to be an independent prognostic marker of 2‑year survival rate by logistic regression analysis (B=‑2.76, P=0.061). Results of this study suggest that P‑gp is a prognostic marker of GBC and the detection of P‑gp and GST‑π may contribute to the prognosis of GBC and the application of chemotherapy as a therapeutic treatment.
View Figures

Figure 1

Figure 2

View References

1 

Mekeel KL and Hemming AW: Surgical management of gallbladder carcinoma: a review. J Gastrointest Surg. 11:1188–1193. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Miller G and Jarnagin WR: Gallbladder carcinoma. Eur J Surg Oncol. 34:306–312. 2008. View Article : Google Scholar

3 

Khdair A, Handa H, Mao G and Panyam J: Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro. Eur J Pharm Biopharm. 71:214–222. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Schrader AJ, Seger M, Konrad L, et al: Clinical impact of MDR1-expression in testicular germ cell cancer. Exp Oncol. 29:212–216. 2007.PubMed/NCBI

5 

Bark H, Xu HD, Kim SH, Yun J and Choi CH: P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state. FEBS Lett. 582:2595–2600. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Berger W, Setinek U, Hollaus P, et al: Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications. J Cancer Res Clin Oncol. 131:355–363. 2005. View Article : Google Scholar

7 

Bottke D, Koychev D, Busse A, et al: Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines. Radiat Res. 170:41–48. 2008. View Article : Google Scholar

8 

Hanson JA, Gillespie JW, Grover A, et al: Gene promoter methylation in prostate tumor-associated stromal cells. J Natl Cancer Inst. 98:255–261. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Pandey SN, Jain M, Nigam P, Choudhuri G and Mittal B: Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India. Biomarkers. 11:250–261. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Tiirikainen MI, Elonen E, Syrjälä MT, Jansson SE and Krusius T: Flow cytometric analysis of glutathione-S-transferase-pi in acute leukemia. Leukemia. 8:978–984. 1994.PubMed/NCBI

11 

Somlo G, Chu P, Frankel P, et al: Molecular profiling including epidermal growth factor receptor and p21 expression in high-risk breast cancer patients as indicators of outcome. Ann Oncol. 19:1853–1859. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Perry AS, Loftus B, Moroose R, et al: In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer. Br J Cancer. 96:1587–1594. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Sutoh I, Kohno H, Nakashima Y, et al: Concurrent expressions of metallothionein, glutathione S-transferase-pi, and P-glycoprotein in colorectal cancers. Dis Colon Rectum. 43:221–232. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Nevin JE, Moran TJ, Kay S and King R: Carcinoma of the gallbladder: staging, treatment, and prognosis. Cancer. 37:141–148. 1976. View Article : Google Scholar : PubMed/NCBI

15 

Henson DE, Albores-Saavedra J and Corle D: Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 70:1493–1497. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Levy AD, Murakata LA and Rohrmann CA Jr: Gallbladder Carcinoma: radiologic-pathologic correlation. Radiographics. 21:295–314. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Gottesman MM and Pastan I: The multidrug transporter, a double-edged sword. J Biol Chem. 263:12163–12166. 1988.PubMed/NCBI

18 

Rodriguez C, Commes T, Robert J and Rossi JF: Expression of P-glycoprotein and anionic glutathione S-transferase genes in non-Hodgkin’s lymphoma. Leuk Res. 17:149–154. 1993.PubMed/NCBI

19 

Kufe DW, Pollock RE, Weichselbaum RR, et al: Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; pp. 711–726. 2003

20 

Stewart DJ: Mechanisms of resistance to cisplatin and carboplatin. Crit Rev Oncol Hematol. 63:12–31. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Chen YK and Lin LM: Placental glutathione S-transferase isoenzyme expression in polycyclic aromatic hydrocarbon-induced hemster buccal pouch mucosa. Oral Oncol. 34:180–185. 1998. View Article : Google Scholar

22 

Tsuchida S and Sato K: Glutathione transferses and cancer. Crit Rev Biochem Mol Biol. 27:337–384. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Takabayashi A, Watkins JB, Soloway RD, Rios-Dalenz J and Henson DE: Glycolithocolic acid is greatly increased in stones from patients with carcinoma of the gallbladder. Gastroenterology. 79:1058–1063. 1980.

24 

Henson DE, Albores-Saavedra J and Corle D: Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 70:1493–1497. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Lazcano-Ponce EC, Miquel JF, Muñoz N, et al: Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 51:349–364. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Seo S, Hatano E, Higashi T, et al: Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma. Clin Cancer Res. 13:427–433. 2007. View Article : Google Scholar

27 

Sinicrope FA, Hart J, Brasitus TA, Michelassi F, Lee JJ and Safa AR: Relationship of P-glycoprotein and carcinoenbryonic antigen expression in human colon carcinoma to local invision, DNA ploidy, and disease relapse. Cancer. 74:2908–2907. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Saint-Ruf C, Malfoy B, Scholl S, Zafrani B and Dutrillaux B: GST gene is frequently complified with INT2 and HSTF1 proto-oncogene in human breast cancers. Oncogene. 16:403–406. 1991.PubMed/NCBI

29 

Slebos RJ, Kibbelaar RE, Dalesio O, et al: K-ras oncogene activation as a prognostic marker in adenocarcinomar of the lung. N Eng J Med. 323:561–565. 1990. View Article : Google Scholar : PubMed/NCBI

30 

Tsuda H, Hirohashi S, Shimosato Y, et al: Correlation between long-term survival in breast cancer patients and amplification of two putive oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1. Cancer Res. 49:3104–3108. 1989.PubMed/NCBI

31 

Charpin C, Vielh P, Duffaud F, et al: Quantitative immunocytochemical assays of P-glycoprotein in breast carcinoma: correlation to messanger RNA experession and to immunohistochemical prognostic indicators. J Natl Cancer Inst. 86:1539–1545. 1994. View Article : Google Scholar

32 

Ralhan R, Swain RK, Agarwal S, et al: P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis. Int J Cancer. 84:80–85. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Malik IA: Gallbladder cancer: current status. Expert Opin Pharmacother. 5:1271–1277. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Brotherick I, Shenton BK, Egan M, et al: Examination of multidrug resistance in cell lines and primary breast tumours by flow cytometry. Eur J Cancer. 32A:2334–2341. 1996. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma QJ, Zhang YC, Shi JS and Li GC: Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Exp Ther Med 7: 635-639, 2014.
APA
Ma, Q., Zhang, Y., Shi, J., & Li, G. (2014). Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Experimental and Therapeutic Medicine, 7, 635-639. https://doi.org/10.3892/etm.2014.1472
MLA
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7.3 (2014): 635-639.
Chicago
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7, no. 3 (2014): 635-639. https://doi.org/10.3892/etm.2014.1472
Copy and paste a formatted citation
x
Spandidos Publications style
Ma QJ, Zhang YC, Shi JS and Li GC: Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Exp Ther Med 7: 635-639, 2014.
APA
Ma, Q., Zhang, Y., Shi, J., & Li, G. (2014). Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma. Experimental and Therapeutic Medicine, 7, 635-639. https://doi.org/10.3892/etm.2014.1472
MLA
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7.3 (2014): 635-639.
Chicago
Ma, Q., Zhang, Y., Shi, J., Li, G."Clinical significance of P‑glycoprotein and glutathione S‑transferase π expression in gallbladder carcinoma". Experimental and Therapeutic Medicine 7, no. 3 (2014): 635-639. https://doi.org/10.3892/etm.2014.1472
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team