Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus

  • Authors:
    • Bin Zhu
    • Zhi‑Gang Wang
    • Jie Ding
    • Ning Liu
    • Da‑Ming Wang
    • Liang‑Cai Ding
    • Chun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China, Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China, Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China
  • Pages: 750-754
    |
    Published online on: January 8, 2014
       https://doi.org/10.3892/etm.2014.1479
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have shown that lipopolysaccharide (LPS) has the potential to cause cognitive dysfunction. However, the underlying pathogenesis has yet to be fully elucidated. Increasing attention is being focused on infection in the central nervous system. Therefore, the present study aimed to investigate the behavioral performance of rats receiving intraperitoneal injections of LPS and to determine the expression levels of amyloid‑β (Aβ), brain‑derived neurotrophic factor (BDNF) and pro‑inflammatory cytokines in the hippocampus. In total, 30 male Wistar rats were randomly divided into 3 groups (each n=10): Control and 3 and 7 day LPS administration groups. The rats were intraperitoneally injected with saline or LPS for 3 or 7 days. Following this, rats performed the Morris water maze test, in which the latency to the platform and proportion of time spent in the target quadrant were recorded. Rats were then sacrificed and the hippocampi were harvested for determination of interleukin (IL)‑1β, IL‑6, tumor necrosis factor‑α (TNF‑α), Aβ and BDNF expression levels. LPS administration for 3 and 7 days significantly increased the latency to the platform and decreased the proportion of time spent in the target quadrant compared with those in the control group, (P<0.05). Administration of LPS for 3 and 7 days induced statistically significant increases in the expression levels of IL‑1β, IL‑6 and TNF‑α in the hippocampus, compared with those in the control group (P<0.05). Additionally, the administration of LPS for 7 days induced a statistically significant increase in the expression level of Aβ in the hippocampus, compared with that in the control group (P<0.05). However, the administration of LPS did not elicit a statistically significant change in the expression level of BDNF in the hippocampus, compared with that in the control group (P>0.05). The results indicate that LPS induces cognitive dysfunction, which is associated with increased expression levels of pro‑inflammatory cytokines and Aβ, but does not affect the expression of BDNF in the hippocampus.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Adam N, Kandelman S, Mantz J, Chrétien F and Sharshar T: Sepsis-induced brain dysfunction. Expert Rev Anti Infect Ther. 11:211–221. 2013. View Article : Google Scholar

2 

Zampieri FG, Park M, Machado FS and Azevedo LC: Sepsis-associated encephalopathy: not just delirium. Clinics (Sao Paulo). 66:1825–1831. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Guan Z and Fang J: Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats. Brain Behav Immun. 20:64–71. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Suzumura A, Takeuchi H, Zhang G, Kuno R and Mizuno T: Roles of glia-derived cytokines on neuronal degeneration and regeneration. Ann NY Acad Sci. 1088:219–229. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Wang Y, Cui XL, Liu YF, et al: LPS inhibits the effects of fluoxetine on depression-like behavior and hippocampal neurogenesis in rats. Prog Neuropsychopharmacol Biol Psychiatry. 35:1831–1835. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Deng XH, Ai WM, Lei DL, Luo XG, Yan XX and Li Z: Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats. Neuroscience. 209:161–170. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Richwine AF, Sparkman NL, Dilger RN, Buchanan JB and Johnson RW: Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide. Brain Behav Immun. 23:794–802. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL and Johnson RW: Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci. 26:10709–10716. 2006. View Article : Google Scholar

9 

Dantzer R, O’Connor JC, Freund GG, Johnson RW and Kelley KW: From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 9:46–56. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Smith CJ, Emsley HC, Udeh CT, et al: Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine. 58:384–389. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Krzyszton CP, Sparkman NL, Grant RW, et al: Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation. Am J Physiol Regul Integr Comp Physiol. 295:R1109–R1114. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Johnston H, Boutin H and Allan SM: Assessing the contribution of inflammation in models of Alzheimer’s disease. Biochem Soc Trans. 39:886–890. 2011.PubMed/NCBI

13 

Kaster MP, Gadotti VM, Calixto JB, Santos AR and Rodrigues AL: Depressive-like behavior induced by tumor necrosis factor-α in mice. Neuropharmacology. 62:419–426. 2012.

14 

Mansur RB, Zugman A, Asevedo EM, da Cunha GR, Bressan RA and Brietzke E: Cytokines in schizophrenia: possible role of anti-inflammatory medications in clinical and preclinical stages. Psychiatry Clin Neurosci. 66:247–260. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Pizza V, Agresta A, D’Acunto CW, Festa M and Capasso A: Neuroinflamm-aging and neurodegenerative diseases: an overview. CNS Neurol Disord Drug Targets. 10:621–634. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Magaki S, Mueller C, Dickson C and Kirsch W: Increased production of inflammatory cytokines in mild cognitive impairment. Exp Gerontol. 42:233–240. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Oral E, Canpolat S, Yildirim S, Gulec M, Aliyev E and Aydin N: Cognitive functions and serum levels of brain-derived neurotrophic factor in patients with major depressive disorder. Brain Res Bull. 88:454–459. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Zhang XY, Liang J, Chen da C, et al: Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology (Berl). 222:277–284. 2012. View Article : Google Scholar : PubMed/NCBI

19 

D’Hooge R and De Deyn PP: Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev. 36:60–90. 2001.PubMed/NCBI

20 

Solov’eva T, Davydova V, Krasikova I and Yermak I: Marine compounds with therapeutic potential in gram-negative sepsis. Mar Drugs. 11:2216–2229. 2013.PubMed/NCBI

21 

Skelly DT, Hennessy E, Dansereau MA and Cunningham C: A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, TNF-α and IL-6 challenges in C57BL/6 mice. PLoS One. 8:e691232013.PubMed/NCBI

22 

Shaw KN, Commins S and O’Mara SM: Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav Brain Res. 124:47–54. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Leung R, Proitsi P, Simmons A, et al: Inflammatory proteins in plasma are associated with severity of Alzheimer’s disease. PLoS One. 8:e649712013.

24 

Reale M, Iarlori C, Gambi F, et al: Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J Neuroimmunol. 148:162–171. 2004. View Article : Google Scholar

25 

Hsu LJ, Mallory M, Xia Y, et al: Expression pattern of synucleins (non-Abeta component of Alzheimer’s disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 71:338–344. 1998.

26 

Nguyen JT, Yamani A and Kiso Y: Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer’s disease: progress and problems. Curr Pharm Des. 12:4295–4312. 2006.PubMed/NCBI

27 

Yan Q, Rosenfeld RD, Matheson CR, et al: Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience. 78:431–448. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Lapchak PA, Araujo DM and Hefti F: Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. 53:297–301. 1993. View Article : Google Scholar

29 

Maher FO, Martin DS and Lynch MA: Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. Neurobiol Aging. 25:795–806. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Taishi P, Churchill L, De A, Obal F Jr and Krueger JM: Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo. Brain Res. 1226:89–98. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Schnydrig S, Korner L, Landweer S, et al: Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain. Neurosci Lett. 429:69–73. 2007. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu B, Wang ZG, Ding J, Liu N, Wang DM, Ding LC and Yang C: Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Exp Ther Med 7: 750-754, 2014.
APA
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., & Yang, C. (2014). Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Experimental and Therapeutic Medicine, 7, 750-754. https://doi.org/10.3892/etm.2014.1479
MLA
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., Yang, C."Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus". Experimental and Therapeutic Medicine 7.3 (2014): 750-754.
Chicago
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., Yang, C."Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus". Experimental and Therapeutic Medicine 7, no. 3 (2014): 750-754. https://doi.org/10.3892/etm.2014.1479
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu B, Wang ZG, Ding J, Liu N, Wang DM, Ding LC and Yang C: Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Exp Ther Med 7: 750-754, 2014.
APA
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., & Yang, C. (2014). Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Experimental and Therapeutic Medicine, 7, 750-754. https://doi.org/10.3892/etm.2014.1479
MLA
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., Yang, C."Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus". Experimental and Therapeutic Medicine 7.3 (2014): 750-754.
Chicago
Zhu, B., Wang, Z., Ding, J., Liu, N., Wang, D., Ding, L., Yang, C."Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus". Experimental and Therapeutic Medicine 7, no. 3 (2014): 750-754. https://doi.org/10.3892/etm.2014.1479
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team