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Article

Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart

  • Authors:
    • Haijian Luo
    • Junqiang Si
    • Fengjie Zhang
    • Zhenyu Yang
    • Ruxing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. China, Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China
  • Pages: 755-757
    |
    Published online on: January 15, 2014
       https://doi.org/10.3892/etm.2014.1486
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Abstract

Cardiac electrophysiological heterogeneity related to the washout of acetylcholine (ACh) remains incompletely characterized. The aim of this study was to examine whether positive cardiac inotropic action is associated with electrophysiological heterogeneity between the atrium and the ventricle after ACh perfusion and washout. Epicardial monophasic action potentials (MAPs) from the right ventricle and right atrium, as well as cardiac contractility, were recorded from isolated Langendorff-perfused rabbit hearts using MAP electrodes and a force transducer. The results indicated that rebound positive inotropic actions were induced by ACh washout with adrenaline preconditioning. This effect was accompanied by an increase in MAP amplitude (MAPA) in the right ventricle but not the right atrium. These findings indicate that cholinergic muscarinic stimulation may lead to positive cardiac inotropic action followed by changes in regional electrophysiological heterogeneity between the atrial and ventricular myocardium. Therefore, we hypothesize that electrophysiological heterogeneity is an underlying cause of arrhythmogenesis as well as hemodynamic disturbance elicited by sudden termination of vagus stimulation.
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1 

Bender K, Wellner-Kienitz MC, Bosche LI, Rinne A, Beckmann C and Pott L: Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow. J Physiol. 561:471–483. 2004.PubMed/NCBI

2 

Choisy SC, James AF and Hancox JC: Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node. Biochem Biophys Res Commun. 423:496–502. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Shui Z, Yamanushi TT and Boyett MR: Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels. Am J Physiol Heart Circ Physiol. 280:H2554–H2562. 2001.PubMed/NCBI

4 

Yamanushi TT, Shui Z, Leach RN, Dobrzynski H, Claydon TW and Boyett MR: Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart. Am J Physiol Heart Circ Physiol. 292:H1737–H1746. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Belevych AE, Sims C and Harvey RD: ACh-induced rebound stimulation of L-type Ca(2+) current in guinea-pig ventricular myocytes, mediated by Gbetagamma-dependent activation of adenylyl cyclase. J Physiol. 536:677–692. 2001.PubMed/NCBI

6 

Godecke A, Heinicke T, Kamkin A, et al: Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. J Physiol. 532:195–204. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Maruyama M, Lin SF, Xie Y, et al: Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome. Circ Arrhythm Electrophysiol. 4:103–111. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Bryant SM, Shipsey SJ and Hart G: Regional differences in electrical and mechanical properties of myocytes from guinea-pig hearts with mild left ventricular hypertrophy. Cardiovasc Res. 35:315–323. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Bishop MJ, Vigmond EJ and Plank G: The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias. Am J Physiol Heart Circ Physiol. 304:H1240–H1252. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ravelli F: Mechano-electric feedback and atrial arrhythmias. Mechanosensitivity in Cells and Tissues. Kamkin A and Kiseleva I: Academia Publishing House Ltd; Moscow: 2005

11 

Wyse DG and Gersh BJ: Atrial fibrillation: a perspective: thinking inside and outside the box. Circulation. 109:3089–3095. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Brack KE, Coote JH and Ng GA: The effect of direct autonomic nerve stimulation on left ventricular force in the isolated innervated Langendorff perfused rabbit heart. Auton Neurosci. 124:69–80. 2006. View Article : Google Scholar

13 

Aydin O, Becker R, Kraft P, et al: Effects of protein kinase C activation on cardiac repolarization and arrhythmogenesis in Langendorff-perfused rabbit hearts. Europace. 9:1094–1098. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Cheng J, Ma X, Zhang J and Su D: Diverse modulating effects of estradiol and progesterone on the monophasic action potential duration in Langendorff-perfused female rabbit hearts. Fundam Clin Pharmacol. 26:219–226. 2012. View Article : Google Scholar

15 

Okada M, Mizuno W, Nakarai R, Matada T, Yamawaki H and Hara Y: Benzodiazepines inhibit the acetylcholine receptor-operated potassium current (IK.ACh) by different mechanisms in guinea-pig atrial myocytes. J Vet Med Sci. 74:879–884. 2012. View Article : Google Scholar

16 

Brodde OE and Michel MC: Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev. 51:651–690. 1999.PubMed/NCBI

17 

Guiraudou P, Pucheu SC, Gayraud R, et al: Involvement of nitric oxide in amiodarone- and dronedarone-induced coronary vasodilation in guinea pig heart. Eur J Pharmacol. 496:119–127. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Cheng H, Smith GL, Orchard CH, Hancox JC and Burton FL: Inhibition of sarcoplasmic reticulum Ca(2+)-ATPase decreases atrioventricular node-paced heart rate in rabbits. Exp Physiol. 97:1131–1139. 2012.

19 

Link S, Meissner M, Held B, et al: Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem. 284:30129–30137. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Bodi I, Mikala G, Koch SE, Akhter SA and Schwartz A: The L-type calcium channel in the heart: the beat goes on. J Clin Invest. 115:3306–3317. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Lee YS, Maruyama M, Chang PC, et al: Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles. Heart Rhythm. 9:1125–1132. 2012. View Article : Google Scholar

22 

Farkas AS, Acsai K, Nagy N, et al: Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart. Br J Pharmacol. 154:93–104. 2008.

23 

Hayashi H, Kamanu SD, Ono N, et al: Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles. Heart Rhythm. 5:116–123. 2008. View Article : Google Scholar

24 

Aslanidi OV, Robinson R, Cheverton D, Boyett MR and Zhang H: Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. Conf Proc IEEE Eng Med Biol Soc. 2009:2819–2822. 2009.PubMed/NCBI

25 

Smith RM, Velamakanni SS and Tolkacheva EG: Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart. Am J Physiol Heart Circ Physiol. 303:H224–H233. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo H, Si J, Zhang F, Yang Z and Wang R: Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart. Exp Ther Med 7: 755-757, 2014.
APA
Luo, H., Si, J., Zhang, F., Yang, Z., & Wang, R. (2014). Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart. Experimental and Therapeutic Medicine, 7, 755-757. https://doi.org/10.3892/etm.2014.1486
MLA
Luo, H., Si, J., Zhang, F., Yang, Z., Wang, R."Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart". Experimental and Therapeutic Medicine 7.3 (2014): 755-757.
Chicago
Luo, H., Si, J., Zhang, F., Yang, Z., Wang, R."Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart". Experimental and Therapeutic Medicine 7, no. 3 (2014): 755-757. https://doi.org/10.3892/etm.2014.1486
Copy and paste a formatted citation
x
Spandidos Publications style
Luo H, Si J, Zhang F, Yang Z and Wang R: Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart. Exp Ther Med 7: 755-757, 2014.
APA
Luo, H., Si, J., Zhang, F., Yang, Z., & Wang, R. (2014). Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart. Experimental and Therapeutic Medicine, 7, 755-757. https://doi.org/10.3892/etm.2014.1486
MLA
Luo, H., Si, J., Zhang, F., Yang, Z., Wang, R."Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart". Experimental and Therapeutic Medicine 7.3 (2014): 755-757.
Chicago
Luo, H., Si, J., Zhang, F., Yang, Z., Wang, R."Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart". Experimental and Therapeutic Medicine 7, no. 3 (2014): 755-757. https://doi.org/10.3892/etm.2014.1486
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