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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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2014-April Volume 7 Issue 4

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Case Report

Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature

  • Authors:
    • Meiling Lv
    • Yuyao Li
    • Changqin Luo
    • Peijun Liu
    • Jin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China, Clinical and Translational Science Center, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 982-986
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/etm.2014.1500
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Abstract

Splenic metastasis of ovarian cancer appears to be more common in serous cystadenocarcinomas. Splenic metastasis usually occurs postoperatively and simultaneously with dissemination to the greater omentum and pelvic cavity. Compared with other ovarian cancer subtypes, ovarian clear cell adenocarcinoma (OCCA) is rare, accounting for <5% of all ovarian malignancies. OCCA has a distinct histological type with poor prognosis and resistance to platinum-based chemotherapy. In the present study, a case of isolated splenic metastasis of OCCA was reported. A 53-year-old female presented with a mass in the left upper quadrant without any other clinical manifestations. Subsequent abdominal and pelvic computed tomography scans revealed multiple mixed cystic-solid lesions, potentially predicting ovarian malignancy. Pathological tests following ovarian cytoreductive surgery revealed primary OCCA with metastases to the spleen. The current study also reviewed recently published literature on splenic metastasis of ovarian carcinoma and demonstrated that the reported case was a rare case of isolated splenic metastasis of OCCA.
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1 

Fleming GF, Ronnett BM and Seidman J: Epithelial ovarian cancer. Principles and Practice of Gynecologic Oncology. Barakat RR, Markman M and Randall ME: 5th edition. Lippincott Williams & Wilkins; Philadelphia, PA: pp. 763–836. 2009

2 

Chan JK, Cheung MK, Husain A, et al: Patterns and progress in ovarian cancer over 14 years. Obstet Gynecol. 108:521–528. 2006.PubMed/NCBI

3 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar

4 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

5 

Sugawa T, Umesaki N, Yajima A, et al: A group study on prognosis of ovarian cancer in Japan. Nihon Sanka Fukinka Gakki Zasshi. 44:827–832. 1992.(In Japanese).

6 

O’Brien ME, Schofield JB, Tan S, et al: Clear cell epithelial ovarian cancer (mesonephroid): bad prognosis only in early stages. Gynecol Oncol. 49:250–254. 1993.PubMed/NCBI

7 

Sugiyama T, Kamura T, Kigawa J, et al: Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer. 88:2584–2589. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Lam KY and Tang V: Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med. 124:526–530. 2000.PubMed/NCBI

9 

Izuishi K, Sano T, Usuki H, et al: Isolated splenic metastasis of ovarian cancer 20 years after operation: a case report and literature review. Tumor. 96:784–786. 2010.PubMed/NCBI

10 

Ghani AA, Hashmi ZA, Chase DM, et al: Intraparenchymal metastases to the spleen from ovarian cancer: a case report. J Med Case Rep. 4:302010. View Article : Google Scholar

11 

Yano H, Iwazawa T, Kinuta M, et al: Solitary splenic metastasis from ovarian cancer successfully treated by hand-assisted laparoscopic splenectomy: report of a case. Surg Today. 32:750–752. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Koh YS, Kim JC and Cho CK: Splenectomy for solitary splenic metastasis of ovarian cancer. BMC Cancer. 4:962004. View Article : Google Scholar : PubMed/NCBI

13 

Yoshioka R, Okabayashi T, Nishimori I, et al: A long-survived case with solitary splenic metastasis from ovarian carcinoma. Surg Technol Int. 17:192–194. 2008.PubMed/NCBI

14 

Alloni R, Garberini A, Caputo D and Coppola R: Solitary splenic metastasis of ovarian carcinoma: report of two cases. Surg Today. 38:1144–1147. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Furukawa N: Solitary splenic metastasis of ovarian cancer. Arch Gynecol Obstet. 275:499–502. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ushijima K, Nishida T, Okura N, et al: Solitary splenic recurrence of ovarian cancer: case report and review of the literature. Arch Gynecol Obstet. 263:79–81. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Valbuena JR, Levenback C, Mansfield P and Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol. 9:289–292. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Otrock ZK, Seoud MA, Khalifeh MJ, et al: Laparoscopic splenectomy for isolated parenchymal splenic metastasis of ovarian cancer. Int J Gynecol Cancer. 16:1933–1935. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Olsen AB, Parqman S and Gillespie T: Solitary splenic metastasis from ovarian carcinosarcoma: a case report. J Med Case Rep. 5:562011. View Article : Google Scholar : PubMed/NCBI

20 

Hasegawa H, Naitoh H, Tsuchihashi H, et al: A case of solitary splenic metastasis from an ovarian cancer 12 years after primary resection. Gan To Kagaku Ryoho. 37:1799–1803. 2010.(In Japanese).

21 

Teilum G: Gonocytoma homologous ovarian and testicular tumours. Acta Pathol Microbiol Scand. 23:242–251. 1946.

22 

Scully RE: Recent progress in ovarian cancer. Hum Pathol. 1:73–98. 1970. View Article : Google Scholar

23 

Serov SF, Scully RE and Sobin LH: International histologic classification of tumours. (9)Histologic typing of ovarian tumours. World Health Organization; Geneva: 1973

24 

Tan DS and Kaye S: Ovarian clear cell adenocarcinoma: a continuing enigma. J Clin Pathol. 60:355–360. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Miyamoto M, Takano M, Goto T, et al: Clear cell histology as a poor prognostic factor for advanced epithelial ovarian cancer: a single institutional case series through central pathologic review. J Gynecol Oncol. 24:37–43. 2013. View Article : Google Scholar

26 

Takano M, Kikuchi Y, Yaegashi N, et al: Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer. 94:1369–1374. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Morgenstern L, Rosenberg J and Geller SA: Tumors of the spleen. World J Surg. 9:468–476. 1985. View Article : Google Scholar

28 

Siler J, Hunter TB, Weiss J and Haber K: Increased echogenicity of the spleen in benign and malignant disease. AJR Am J Roentgenol. 134:1011–1014. 1980. View Article : Google Scholar : PubMed/NCBI

29 

Capizzi PJ, Allen KB, Amerson JR and Skandalakis JE: Isolated splenic metastasis from rectal carcinoma. South Med J. 85:1003–1005. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Lauro S, Trasatti L, Capalbo C, et al: Solitary splenic recurrence of epithelial ovarian cancer:a case report and review. Anticancer Res. 22:3643–3645. 2002.PubMed/NCBI

31 

Bristow RE, Tomacruz RS, Armstrong DK, et al: Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 20:1248–1259. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Spencer NJ, Spencer JA, Perren TJ and Lane G: CT appearances and prognostic significance of splenic metastasis in ovarian cancer. Clin Radiol. 53:417–421. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Senturk S, Karcaaltıncaba M and Akata D: CT diagnosis of intrasplenic metastasis from ovarian carcinoma. Eur J Radiol. 81:1094–1099. 2012. View Article : Google Scholar

34 

Chen LM, Leuchter RS, Lagasse LD and Karlan BY: Splenectomy and surgical cytoreduction for ovarian cancer. Gynecol Oncol. 77:362–368. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Eisenkop SM, Spirtos NM, Friedman RL, et al: Relative influences of tumor volume before surgery and the cytoreductive outcome on survival for patients with ovarian cancer: a prospective study. Gynecol Oncol. 90:390–396. 2003.

36 

Eisenkop SM, Spirtos NM and Lin WCM: Splenectomy in the context of primary cytoreductive operations for advanced epithelial ovarian cancer. Gynecol Oncol. 100:344–348. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Magtibay PM, Adams PB, Silverman MB, et al: Splenectomy as part of cytoreductive surgery in ovarian cancer. Gynecol Oncol. 100:369–374. 2006. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lv M, Li Y, Luo C, Liu P and Yang J: Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. Exp Ther Med 7: 982-986, 2014.
APA
Lv, M., Li, Y., Luo, C., Liu, P., & Yang, J. (2014). Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. Experimental and Therapeutic Medicine, 7, 982-986. https://doi.org/10.3892/etm.2014.1500
MLA
Lv, M., Li, Y., Luo, C., Liu, P., Yang, J."Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature". Experimental and Therapeutic Medicine 7.4 (2014): 982-986.
Chicago
Lv, M., Li, Y., Luo, C., Liu, P., Yang, J."Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature". Experimental and Therapeutic Medicine 7, no. 4 (2014): 982-986. https://doi.org/10.3892/etm.2014.1500
Copy and paste a formatted citation
x
Spandidos Publications style
Lv M, Li Y, Luo C, Liu P and Yang J: Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. Exp Ther Med 7: 982-986, 2014.
APA
Lv, M., Li, Y., Luo, C., Liu, P., & Yang, J. (2014). Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. Experimental and Therapeutic Medicine, 7, 982-986. https://doi.org/10.3892/etm.2014.1500
MLA
Lv, M., Li, Y., Luo, C., Liu, P., Yang, J."Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature". Experimental and Therapeutic Medicine 7.4 (2014): 982-986.
Chicago
Lv, M., Li, Y., Luo, C., Liu, P., Yang, J."Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature". Experimental and Therapeutic Medicine 7, no. 4 (2014): 982-986. https://doi.org/10.3892/etm.2014.1500
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