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Article

Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease

  • Authors:
    • Jun‑Bo Hong
    • Liang Xia
    • Wei Zuo
    • An‑Jiang Wang
    • Shan Xu
    • Hui‑Fang Xiong
    • You‑Xiang Chen
    • Xuan Zhu
    • Nong‑Hua Lu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 929-934
    |
    Published online on: January 28, 2014
       https://doi.org/10.3892/etm.2014.1507
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Abstract

The aim of this study was to estimate the prevalence and risk factors of intestinal metaplasia (IM) in concomitant gastric and duodenal ulcer (CGDU) disease by retrospectively reviewing consecutive patients who had undergone esophagogastroduodenal endoscopy. Patients who received the endoscopic diagnosis of CGDU disease were selected for analysis and the recorded demographic, endoscopic, clinical and outcome data, including data on the development of IM, were extracted. Associations of the various parameters with IM were estimated by logistic regression analysis and described by the odds ratio (OR) with a 95% confidence interval (CI). Among the total 204,073 consecutive patients screened, 2,397 (1.2%) were diagnosed with CGDU disease. Following application of the exclusion criteria, a total of 2,149 cases were included in the study. The IM prevalence was 8.4%, represented by 153 mild cases, 26 moderate cases and one severe case. Multivariate analysis identified age ≥50 years (OR=2.606, 95% CI=1.889‑3.597, χ2=34.000, P<0.001), ulcer at the gastric incisura (OR=2.644, 95% CI=1.926‑3.630, χ2=36.142, P<0.001) and Helicobacter pylori (H. pylori) infection (OR=2.338, 95% CI=1.573‑3.474, χ2=17.648, P<0.001) as independent risk factors for the development of IM. In addition, the moderate and severe IM grades were more frequently detected in males than in females (18.8% vs. 5.8%; OR=3.769, 95% CI=1.083‑13.121, χ2=4.887, P=0.036). IM in patients with CGDU disease is not uncommon. CGDU patients with ongoing H. pylori infection, gastric incisura involvement, older age and/or male gender may be at a higher risk of IM.
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Copy and paste a formatted citation
Spandidos Publications style
Hong JB, Xia L, Zuo W, Wang AJ, Xu S, Xiong HF, Chen YX, Zhu X and Lu NH: Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease. Exp Ther Med 7: 929-934, 2014.
APA
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H. ... Lu, N. (2014). Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease. Experimental and Therapeutic Medicine, 7, 929-934. https://doi.org/10.3892/etm.2014.1507
MLA
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H., Chen, Y., Zhu, X., Lu, N."Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease". Experimental and Therapeutic Medicine 7.4 (2014): 929-934.
Chicago
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H., Chen, Y., Zhu, X., Lu, N."Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease". Experimental and Therapeutic Medicine 7, no. 4 (2014): 929-934. https://doi.org/10.3892/etm.2014.1507
Copy and paste a formatted citation
x
Spandidos Publications style
Hong JB, Xia L, Zuo W, Wang AJ, Xu S, Xiong HF, Chen YX, Zhu X and Lu NH: Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease. Exp Ther Med 7: 929-934, 2014.
APA
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H. ... Lu, N. (2014). Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease. Experimental and Therapeutic Medicine, 7, 929-934. https://doi.org/10.3892/etm.2014.1507
MLA
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H., Chen, Y., Zhu, X., Lu, N."Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease". Experimental and Therapeutic Medicine 7.4 (2014): 929-934.
Chicago
Hong, J., Xia, L., Zuo, W., Wang, A., Xu, S., Xiong, H., Chen, Y., Zhu, X., Lu, N."Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease". Experimental and Therapeutic Medicine 7, no. 4 (2014): 929-934. https://doi.org/10.3892/etm.2014.1507
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