Type‑I interferon secretion in the acute phase promotes Cryptococcus neoformans infection‑induced Th17 cell polarization in vitro

  • Authors:
    • Hai‑Jun Qin
    • Qi‑Ming Feng
    • Yong Fang
    • Lei Shen
  • View Affiliations

  • Published online on: January 30, 2014     https://doi.org/10.3892/etm.2014.1517
  • Pages: 869-872
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Abstract

Cryptococcosis is a potentially fatal fungal disease commonly identified in patients with acquired immunodeficiency syndrome. Cryptococcus infection induces strong pro‑inflammatory cytokine secretion, i.e. type‑I interferon (IFN‑I) via the Toll‑like receptor signaling pathway. However, innate immune responses are insufficient in host defense against fungi infection and the clearance of Cryptococcus is dependent on the T helper (Th)17 cell‑mediated mucosal immune response. In this study, IFN‑I was identified as the early response cytokine to Cryptococcus neoformans infection via quantitative PCR (qPCR) and IFN‑I was demonstrated to be crucial for interleukin (IL)‑17A secretion in T cells, but not in innate immune cells. In addition, blockade of IFN‑I reduced the protein expression levels of IL‑22 and IL‑23 in Th17 cells in vitro. These results suggest additional functions of IFN‑I in immune regulation, which may be pivotal for the development of clinical immune therapy.
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2014-April
Volume 7 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qin HJ, Feng QM, Fang Y and Shen L: Type‑I interferon secretion in the acute phase promotes Cryptococcus neoformans infection‑induced Th17 cell polarization in vitro. Exp Ther Med 7: 869-872, 2014
APA
Qin, H., Feng, Q., Fang, Y., & Shen, L. (2014). Type‑I interferon secretion in the acute phase promotes Cryptococcus neoformans infection‑induced Th17 cell polarization in vitro. Experimental and Therapeutic Medicine, 7, 869-872. https://doi.org/10.3892/etm.2014.1517
MLA
Qin, H., Feng, Q., Fang, Y., Shen, L."Type‑I interferon secretion in the acute phase promotes Cryptococcus neoformans infection‑induced Th17 cell polarization in vitro". Experimental and Therapeutic Medicine 7.4 (2014): 869-872.
Chicago
Qin, H., Feng, Q., Fang, Y., Shen, L."Type‑I interferon secretion in the acute phase promotes Cryptococcus neoformans infection‑induced Th17 cell polarization in vitro". Experimental and Therapeutic Medicine 7, no. 4 (2014): 869-872. https://doi.org/10.3892/etm.2014.1517