|
1
|
Jemal A, Siegel R, Ward E, Murray T, Xu J
and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66.
2007. View Article : Google Scholar
|
|
2
|
Neoptolemos JP, Stocken DD, Friess H, et
al; European Study Group for Pancreatic Cancer. A randomized trial
of chemoradiotherapy and chemotherapy after resection of pancreatic
cancer. N Engl J Med. 350:1200–1210. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Guo X and Cui Z: Current diagnosis and
treatment of pancreatic cancer in China. Pancreas. 31:13–22. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Schneider G, Siveke JT, Eckel F and Schmid
RM: Pancreatic cancer: basic and clinical aspects.
Gastroenterology. 128:1606–1625. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Fransen E, Lemmon V, Van Camp G, Vits L,
Coucke P and Willems PJ: CRASH syndrome: clinical spectrum of
corpus callosum hypoplasia, retardation, adducted thumbs,
spastic paraparesis and hydrocephalus due to mutations in one
single gene, L1. Eur J Hum Genet. 3:273–284. 1995.PubMed/NCBI
|
|
6
|
Kajiwara Y, Ueno H, Hashiguchi Y, et al:
Expression of l1 cell adhesion molecule and morphologic features at
the invasive front of colorectal cancer. Am J Clin Pathol.
136:138–144. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Schäfer H, Dieckmann C, Korniienko O, et
al: Combined treatment of L1CAM antibodies and cytostatic drugs
improve the therapeutic response of pancreatic and ovarian
carcinoma. Cancer Lett. 319:66–82. 2012.PubMed/NCBI
|
|
8
|
Bao S, Wu Q, Li Z, et al: Targeting cancer
stem cells through L1CAM suppresses glioma growth. Cancer Res.
68:6043–6048. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Hai J, Zhu CQ, Bandarchi B, et al: L1 cell
adhesion molecule promotes tumorigenicity and metastatic potential
in non-small cell lung cancer. Clin Cancer Res. 18:1914–1924. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Li S, Jo YS, Lee JH, et al: L1 cell
adhesion molecule is a novel independent poor prognostic factor of
extrahepatic cholangiocarcinoma. Clin Cancer Res. 15:7345–7351.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ben QW, Wang JC, Liu J, et al: Positive
expression of L1-CAM is associated with perineural invasion and
poor outcome in pancreatic ductal adenocarcinoma. Ann Surg Oncol.
17:2213–2221. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Issa Y, Nummer D, Seibel T, et al:
Enhanced L1CAM expression on pancreatic tumor endothelium mediates
selective tumor cell transmigration. J Mol Med (Berl). 87:99–112.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Silletti S, Yebra M, Perez B, Cirulli V,
McMahon M and Montgomery AM: Extracellular signal-regulated kinase
(ERK)-dependent gene expression contributes to L1 cell adhesion
molecule-dependent motility and invasion. J Biol Chem.
279:28880–28888. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Elbashir SM, Harborth J, Weber K and
Tuschl T: Analysis of gene function in somatic mammalian cells
using small interfering RNAs. Methods. 26:199–213. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zecchini S, Bianchi M, Colombo N, et al:
The differential role of L1 in ovarian carcinoma and normal ovarian
surface epithelium. Cancer Res. 68:1110–1118. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Gast D, Riedle S, Riedle S, et al: L1
augments cell migration and tumor growth but not beta3 integrin
expression in ovarian carcinomas. Int J Cancer. 115:658–665. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Gavert N, Conacci-Sorrell M, Gast D, et
al: L1, a novel target of beta-catenin signaling, transforms cells
and is expressed at the invasive front of colon cancers. J Cell
Biol. 168:633–642. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Arlt MJ, Novak-Hofer I, Gast D, et al:
Efficient inhibition of intra-peritoneal tumor growth and
dissemination of human ovarian carcinoma cells in nude mice by
anti-L1-cell adhesion molecule monoclonal antibody treatment.
Cancer Res. 66:936–943. 2006. View Article : Google Scholar
|
|
19
|
Kiefel H, Bondong S, Erbe-Hoffmann N, et
al: L1CAM-integrin interaction induces constitutive NF-kappaB
activation in pancreatic adenocarcinoma cells by enhancing IL-1beta
expression. Oncogene. 29:4766–4778. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Bondong S, Kiefel H, Hielscher T, et al:
Prognostic significance of L1CAM in ovarian cancer and its role in
constitutive NF-κB activation. Ann Oncol. 23:1795–1802.
2012.PubMed/NCBI
|
|
21
|
Izumoto S and Yoshimine T: Role of neural
cell adhesion molecule L1 in glioma invasion. Nihon Rinsho.
63(Suppl 9): 74–78. 2005.(In Japanese).
|
|
22
|
Voura EB, Ramjeesingh RA, Montgomery AM
and Siu CH: Involvement of integrin alpha(v)beta(3) and cell
adhesion molecule L1 in transendothelial migration of melanoma
cells. Mol Biol Cell. 12:2699–2710. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Min JK, Kim JM, Li S, et al: L1 cell
adhesion molecule is a novel therapeutic target in intrahepatic
cholangiocarcinoma. Clin Cancer Res. 16:3571–3580. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Gavert N, Ben-Shmuel A, Lemmon V, Brabletz
T and Ben-Ze’ev A: Nuclear factor-kappaB signaling and ezrin are
essential for L1-mediated metastasis of colon cancer cells. J Cell
Sci. 123:2135–2143. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Mechtersheimer S, Gutwein P, Agmon-Levin
N, et al: Ectodomain shedding of L1 adhesion molecule promotes cell
migration by autocrine binding to integrins. J Cell Biol.
155:661–673. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Gavert N, Sheffer M, Raveh S, et al:
Expression of L1-CAM and ADAM10 in human colon cancer cells induces
metastasis. Cancer Res. 67:7703–7712. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sebens Müerköster S, Werbing V, Sipos B,
et al: Drug-induced expression of the cellular adhesion molecule
L1CAM confers anti-apoptotic protection and chemoresistance in
pancreatic ductal adenocarcinoma cells. Oncogene. 26:2759–2768.
2007.PubMed/NCBI
|
|
28
|
Boo YJ, Park JM, Kim J, et al: L1
expression as a marker for poor prognosis, tumor progression, and
short survival in patients with colorectal cancer. Ann Surg Oncol.
14:1703–1711. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Kodera Y, Nakanishi H, Ito S, et al:
Expression of L1 cell adhesion molecule is a significant prognostic
factor in pT3-stage gastric cancer. Anticancer Res. 29:4033–4039.
2009.PubMed/NCBI
|
|
30
|
Rawnaq T, Kleinhans H, Uto M, et al:
Subset of esophageal adenocarcinoma expresses adhesion molecule l1
in contrast to squamous cell carcinoma. Anticancer Res.
29:1195–1199. 2009.PubMed/NCBI
|
|
31
|
Schröder C, Schumacher U, Fogel M, et al:
Expression and prognostic value of L1-CAM in breast cancer. Oncol
Rep. 22:1109–1117. 2009.PubMed/NCBI
|
|
32
|
Schaefer AW, Kamiguchi H, Wong EV, Beach
CM, Landreth G and Lemmon V: Activation of the MAPK signal cascade
by the neural cell adhesion molecule L1 requires L1
internalization. J Biol Chem. 274:37965–37973. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Gast D, Riedle S, Issa Y, et al: The
cytoplasmic part of L1-CAM controls growth and gene expression in
human tumors that is reversed by therapeutic antibodies. Oncogene.
27:1281–1289. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Cheng L, Lemmon S and Lemmon V: RanBPM is
an L1-interacting protein that regulates L1-mediated
mitogen-activated protein kinase activation. J Neurochem.
94:1102–1110. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kiefel H, Bondong S, Pfeifer M, et al:
EMT-associated up-regulation of L1CAM provides insights into
L1CAM-mediated integrin signalling and NF-κB activation.
Carcinogenesis. 33:1919–1929. 2012.PubMed/NCBI
|
|
36
|
Shtutman M, Levina E, Ohouo P, Baig M and
Roninson IB: Cell adhesion molecule L1 disrupts
E-cadherin-containing adherens junctions and increases scattering
and motility of MCF7 breast carcinoma cells. Cancer Res.
66:11370–11380. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Huszar M, Pfeifer M, Schirmer U, et al:
Up-regulation of L1CAM is linked to loss of hormone receptors and
E-cadherin in aggressive subtypes of endometrial carcinomas. J
Pathol. 220:551–561. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Tischler V, Pfeifer M, Hausladen S, et al:
L1CAM protein expression is associated with poor prognosis in
non-small cell lung cancer. Mol Cancer. 10:1272011. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Geismann C, Morscheck M, Koch D, et al:
Up-regulation of L1CAM in pancreatic duct cells is transforming
growth factor beta1- and slug-dependent: role in malignant
transformation of pancreatic cancer. Cancer Res. 69:4517–4526.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Gavert N, Vivanti A, Hazin J, Brabletz T
and Ben-Ze’ev A: L1-mediated colon cancer cell metastasis does not
require changes in EMT and cancer stem cell markers. Mol Cancer
Res. 9:14–24. 2011. View Article : Google Scholar : PubMed/NCBI
|
