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Review

Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review)

  • Authors:
    • Xin Che
    • Xian‑Qun Fan
    • Zhi‑Liang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Ninth People's Hospital Affiliated with Shanghai Jiaotong University, Shanghai 200011, P.R. China
  • Pages: 768-772
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    Published online on: February 6, 2014
       https://doi.org/10.3892/etm.2014.1521
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Abstract

Human immunodeficiency virus (HIV)‑1 has been detected in ocular tissues; however, the mechanism of entry has not been established. It has been hypothesized that the blood‑retinal barrier (BRB), a critical guardian against microbial invasion of the eye, may be compromised in the presence of HIV‑1 in the eye. In vivo and in vitro model systems have shown that the breach of tight junctions induced by HIV‑1‑associated factors contributes to the breakdown of the BRB. The present study reviews the mechanism of tight junction disruption, focusing on signaling pathways, the expression of enzymes, including metalloproteinases, and cytokines that affect inflammation. The studied pathways may be potential targets for the prevention of ocular HIV complications.
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Copy and paste a formatted citation
Spandidos Publications style
Che X, Fan XQ and Wang ZL: Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review). Exp Ther Med 7: 768-772, 2014.
APA
Che, X., Fan, X., & Wang, Z. (2014). Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review). Experimental and Therapeutic Medicine, 7, 768-772. https://doi.org/10.3892/etm.2014.1521
MLA
Che, X., Fan, X., Wang, Z."Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review)". Experimental and Therapeutic Medicine 7.4 (2014): 768-772.
Chicago
Che, X., Fan, X., Wang, Z."Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review)". Experimental and Therapeutic Medicine 7, no. 4 (2014): 768-772. https://doi.org/10.3892/etm.2014.1521
Copy and paste a formatted citation
x
Spandidos Publications style
Che X, Fan XQ and Wang ZL: Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review). Exp Ther Med 7: 768-772, 2014.
APA
Che, X., Fan, X., & Wang, Z. (2014). Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review). Experimental and Therapeutic Medicine, 7, 768-772. https://doi.org/10.3892/etm.2014.1521
MLA
Che, X., Fan, X., Wang, Z."Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review)". Experimental and Therapeutic Medicine 7.4 (2014): 768-772.
Chicago
Che, X., Fan, X., Wang, Z."Mechanism of blood‑retinal barrier breakdown induced by HIV‑1 (Review)". Experimental and Therapeutic Medicine 7, no. 4 (2014): 768-772. https://doi.org/10.3892/etm.2014.1521
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