Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF

Wu,Yaogui; Zheng,Yongfa; Shen,Zhixiang; Ge,Wei; Xie,Yishan; Li,Changhu

doi:10.3892/etm.2014.1526

2014-April Volume 7 Issue 4

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2014-April Volume 7 Issue 4

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Article

Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF

Authors:
- Yaogui Wu
- Yongfa Zheng
- Zhixiang Shen
- Wei Ge
- Yishan Xie
- Changhu Li
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Affiliations: Department of Oncology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China, Department of Gastroenterology, Wuhan University, Renmin Hospital, Wuhan, Hubei 430060, P.R. China
Pages: 911-916
|
Published online on: February 7, 2014

https://doi.org/10.3892/etm.2014.1526
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Abstract

The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor‑β1 (TGF‑β1), hypoxia-inducible factor 1 (HIF‑1α) and basic fibroblast growth factor (bFGF) in lung adenocarcinoma A549 cells, using the antiangiogenesis drug Endostar combined with radiotherapy. In addition, lung adenocarcinoma A549 cell apoptosis was detected via Hoechst staining. The combination of Endostar with radiotherapy was investigated and the results indicated that this combination significantly inhibited tumor cell proliferation and TGF-β1, HIF‑1α and bFGF expression. Changes in gene expression were found to promote apoptosis, thus, enhancing the inhibition of tumor angiogenesis and ultimately inhibiting tumor cell growth, invasion and metastasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF

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