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2014-April Volume 7 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Effects of bone cement on intervertebral disc degeneration

  • Authors:
    • Hui Zhao
    • Cai‑Fang Ni
    • Jian Huang
    • Su‑Ming Zhao
    • Wei‑Wei Gu
    • Hao Jiang
    • Long Chen
    • Tian‑Si Tan
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, The Hospital Affiliated of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Nantong, Jiangsu 215006, P.R. China, Department of Orthopedics, The First Affiliated Hospital of Soochow University, Nantong, Jiangsu 215006, P.R. China
  • Pages: 963-969
    |
    Published online on: February 10, 2014
       https://doi.org/10.3892/etm.2014.1531
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Abstract

Percutaneous vertebroplasty (PVP) is popular for the treatment of intractable pain due to vertebral collapse from various lesions, intervertebral disk leakage of cement is a frequent complication. The aim of this study was to determine whether bone cement causes disc degeneration, and to evaluate the degree of intervertebral disc degeneration (IDD) according to the time period following cement injection, and the type and volume of cement injected. Sixteen dogs were randomly divided into two groups that were sacrificed at 12 or 24 weeks following cement injection. Five intervertebral discs in each dog were studied, including one control untreated disc and four discs randomly injected with polymethylmethacrylate (PMMA) or calcium phosphate cement (CPC) in two quantities. Radiographic and magnetic resonance imaging (MRI) studies were performed prior to animal sacrifice. T2‑weighted mid‑sagittal images of the discs were qualitatively analyzed for evidence of degeneration by calculating the MRI index, and all harvested discs were studied histopathologically. IDD was not evident in control discs. Univariate analysis revealed significant differences in the MRI index and the histological grade of disc degeneration in terms of the time period following cement injection, as well as the type and volume of cement injected. Result indicate that direct contact with PMMA and CPC can lead to IDD. However, IDD induced by PMMA was more severe than that induced by CPC. The extent of IDD was found to correlate with the time period post‑cement injection and the volume of cement injected into the disc. PMMA and CPC may lead to intervertebral disc degeneration. Intervertebral disc degeneration induced by PMMA is more serious than that of CPC. The degree of intervertebral disc degeneration is correlative to the time after operation and the doses of bone cement.
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1 

Mirovsky Y, Anekstein Y, Shalmon E, Blankstein A and Peer A: Intradiscal cement leak following percutaneous vertebroplasty. Spine (Phila Pa 1976). 31:1120–1124. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Galibert P, Deramond H, Rosat P and Le Gars D: Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie. 33:166–168. 1987.(In French).

3 

Cortet B, Cotten A, Boutry N, Flipo RM, Duquesnoy B, Chastanet P and Delcambre B: Percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures: an open prospective study. J Rheumatol. 26:2222–2228. 1999.PubMed/NCBI

4 

Jensen ME, Evans AJ, Mathis JM, Kallmes DF, Cloft HJ and Dion JE: Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral compression fractures: technicalaspects. AJNR Am J Neuroradiol. 18:1897–1904. 1997.

5 

Ahn Y, Lee JH, Lee HY, Lee SH and Keem SH: Predictive factors for subsequent vertebral fracture after percutaneous vertebroplasty. J Neurosurg Spine. 9:129–136. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Chen JK, Lee HM, Shih JT and Hung ST: Combined extraforaminal and intradiscal cement leakage following percutaneous vertebroplasty. Spine (Phila Pa 1976). 32:E358–E362. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Pitton MB, Herber S, Bletz C, et al: CT-guided vertebroplasty in osteoporotic vertebral fractures: incidence of secondary fractures and impact of intradiscal cement leakages during follow-up. Eur Radiol. 18:43–50. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Nieuwenhuijse MJ, Putter H, van Erkel AR and Dijkstra PD: New vertebral fractures after percutaneous vertebroplasty for painful osteoporotic vertebral compression fractures: a clustered analysis and the relevance of intradiskal cement leakage. Radiology. 266:862–870. 2013. View Article : Google Scholar

9 

Nieuwenhuijse MJ, Van Erkel AR and Dijkstra PD: Cement leakage in percutaneous vertebroplasty for osteoporotic vertebral compression nfractures: identification of risk factors. Spine J. 11:839–848. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sobajima S, Kompel JF, Kim JS, et al: A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine (Phila Pa 1976). 30:15–24. 2005.PubMed/NCBI

11 

Brennan P and Silman A: Statistical methods for assessing observer variability in clinical measures. BMJ. 304:1491–1494. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Masuda K, Aota Y, Muehleman C, et al: A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976). 30:5–14. 2005.

13 

Provenzano MJ, Murphy KP and Riley LH III: Bone cements: review of their physiochemical and biochemical properties in percutaneous vertebroplasty. AJNR Am J Neuroradiol. 25:1286–1290. 2004.PubMed/NCBI

14 

Dahl OE, Garvik LJ and Lyberg T: Toxic effects of methymethacrylate monomer on leukocytes and endothelial cells in vitro. Acta Orthop Scand. 65:147–153. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Belkoff SM and Molloy S: Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty. Spine (Phila Pa 1976). 28:1555–1559. 2003. View Article : Google Scholar

16 

Aebli N, Goss BG, Thorpe P, Williams R and Krebs J: In vivo temperature profile of intervertebral discs and vertebral endplates during vertebroplasty: an experimental study in sheep. Spine (Phila Pa 1976). 31:1674–1678. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Hutton WC, Elmer WA, Bryce LM, Kozlowska EE, Boden SD and Kozlowski M: Do the intervertebral disc cells respond to different levels of hydrostatic pressure? Clin Biomech (Bristol, Avon). 16:728–734. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Rannou F, Lee TS, Zhou RH, et al: Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol. 164:915–924. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Baroud G, Heini P, Nemes J, Bohner M, Ferguson S and Steffen T: Biomechanical explanation of adjacent fractures following vertebroplasty. Radiology. 229:606–608. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Walker MH and Anderson DG: Molecular basis of intervertebral disc degeneration. Spine J. 4:158S–166S. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Peh WC, Gilula LA and Peck DD: Percutaneous vertebroplasty for severe osteoporotic vertebral body compression fractures. Radiology. 223:121–126. 2002. View Article : Google Scholar : PubMed/NCBI

22 

An Hs, Takegami K, Kamada H, et al: Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine (Phila Pa 1976). 30:25–31. 2005.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Ni CF, Huang J, Zhao SM, Gu WW, Jiang H, Chen L and Tan TS: Effects of bone cement on intervertebral disc degeneration. Exp Ther Med 7: 963-969, 2014.
APA
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H. ... Tan, T. (2014). Effects of bone cement on intervertebral disc degeneration. Experimental and Therapeutic Medicine, 7, 963-969. https://doi.org/10.3892/etm.2014.1531
MLA
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H., Chen, L., Tan, T."Effects of bone cement on intervertebral disc degeneration". Experimental and Therapeutic Medicine 7.4 (2014): 963-969.
Chicago
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H., Chen, L., Tan, T."Effects of bone cement on intervertebral disc degeneration". Experimental and Therapeutic Medicine 7, no. 4 (2014): 963-969. https://doi.org/10.3892/etm.2014.1531
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Ni CF, Huang J, Zhao SM, Gu WW, Jiang H, Chen L and Tan TS: Effects of bone cement on intervertebral disc degeneration. Exp Ther Med 7: 963-969, 2014.
APA
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H. ... Tan, T. (2014). Effects of bone cement on intervertebral disc degeneration. Experimental and Therapeutic Medicine, 7, 963-969. https://doi.org/10.3892/etm.2014.1531
MLA
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H., Chen, L., Tan, T."Effects of bone cement on intervertebral disc degeneration". Experimental and Therapeutic Medicine 7.4 (2014): 963-969.
Chicago
Zhao, H., Ni, C., Huang, J., Zhao, S., Gu, W., Jiang, H., Chen, L., Tan, T."Effects of bone cement on intervertebral disc degeneration". Experimental and Therapeutic Medicine 7, no. 4 (2014): 963-969. https://doi.org/10.3892/etm.2014.1531
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