Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model

  • Authors:
    • Zhaohui Zhang
    • Pengge Fei
    • Junlin Mu
    • Haoliang Wang
    • Wenqiang Li
    • Jinggui Song
  • View Affiliations / Copyright

    Affiliations: Department of Psychosomatic Medicine, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, P.R. China, Department of Neurology, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, P.R. China, The Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, Henan 453002, P.R. China
  • Pages: 1045-1049
    |
    Published online on: February 12, 2014
       https://doi.org/10.3892/etm.2014.1537
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neuronal Per‑Arnt‑Sim domain protein 4 (NPAS4) is important in regulating transcription and function in the limbic system and in brain development. Post‑stroke depression (PSD) is a common complication following a stroke. Furthermore, organic damage as a result of a stroke affects the restoration of nerve function and indicates that hippocampal neural activity may be associated with PSD. A PSD rat model was established via a middle cerebral artery occlusion procedure, which was combined with isolation and chronic unexpected mild stress, and was used to investigate the expression of the NPAS4 gene in the hippocampus. The neurological deficit and behavior were evaluated and NPAS4 mRNA expression was measured by semi‑quantitative reverse transcription‑polymerase chain reaction; furthermore, the association with cognitive impairment was analyzed. The PSD rats displayed neuropsychopathic disorders and the NPAS4 mRNA expression levels in the hippocampus were significantly lower in the depression and PSD groups compared with the control group. Therefore, the present study identified that NPAS4 expression was decreased in the hippocampus of PSD rats.
View Figures
View References

1 

Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, et al: The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum. Genome Biol. 11:R482010. View Article : Google Scholar : PubMed/NCBI

2 

Prentice LM, d’Anglemont de Tassigny X, McKinney S, Ruiz de Algara T, Yap D, Turashvili G, et al: The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. BMC Genomics. 12:2092011. View Article : Google Scholar : PubMed/NCBI

3 

Raitila A, Lehtonen HJ, Arola J, Heliövaara E, Ahlsten M, Georgitsi M, et al: Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression. Am J Pathol. 177:1969–1976. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Sinanović O: Neuropsychology of acute stroke. Psychiatr Danub. 22:278–281. 2010.

5 

Farner L, Wagle J, Engedal K, Flekkøy KM, Wyller TB and Fure B: Depressive symptoms in stroke patients: a 13 month follow-up study of patients referred to a rehabilitation unit. J Affect Disord. 127:211–218. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Sibon I, Lassalle-Lagadec S, Renou P and Swendsen J: Evolution of depression symptoms following stroke: a prospective study using computerized ambulatory monitoring. Cerebrovasc Dis. 33:280–285. 2012. View Article : Google Scholar : PubMed/NCBI

7 

van Norden AG, Fick WF, de Laat KF, van Uden IW, van Oudheusden LJ, Tendolkar I, et al: Subjective cognitive failures and hippocampal volume in elderly with white matter lesions. Neurology. 71:1152–1159. 2008.PubMed/NCBI

8 

Stanley EM, Wilson MA and Fadel JR: Hippocampal neurotransmitter efflux during one-trial novel object recognition in rats. Neurosci Lett. 511:38–42. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang SH, Zhang ZJ, Guo YJ, Teng GJ and Chen BA: Hippocampal neurogenesis and behavioural studies on adult ischemic rat response to chronic mild stress. Behav Brain Res. 189:9–16. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, et al: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. J Neurosci Res. 89:576–584. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Koizumi J, Yoshida Y, Nakazawa T and Ooneda G: Experimental studies of ischemic brain edema: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke. 8:1–8. 1986. View Article : Google Scholar

13 

Willner P, Towell A, Sampson D, Sophokleous S and Muscat R: Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 93:358–364. 1987. View Article : Google Scholar : PubMed/NCBI

14 

Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, et al: Activity-dependent regulation of inhibitory synapse development by Npas4. Nature. 455:1198–1204. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, et al: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4. J Neurochem. 114:1840–1851. 2010. View Article : Google Scholar

16 

Shamloo M, Soriano L, von Schack D, Rickhag M, Chin DJ, Gonzalez-Zulueta M, et al: Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. Eur J Neurosci. 24:2705–2720. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Pruunsild P, Sepp M, Orav E, Koppel I and Timmusk T: Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. J Neurosci. 31:3295–3308. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Guidotti G, Calabrese F, Auletta F, Olivier J, Racagni G, Homberg J and Riva MA: Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology. 37:746–758. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Zhang ZH, Wu LN, Song JG and Li WQ: Correlations between cognitive impairment and brain-derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Mol Med Rep. 6:889–893. 2012.PubMed/NCBI

20 

Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, et al: Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol. 20:1–17. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Bersten DC, Bruning JB, Peet DJ and Whitelaw ML: Human variants in the neuronal basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One. 9:e857682014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Fei P, Mu J, Wang H, Li W and Song J: Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model. Exp Ther Med 7: 1045-1049, 2014.
APA
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., & Song, J. (2014). Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model. Experimental and Therapeutic Medicine, 7, 1045-1049. https://doi.org/10.3892/etm.2014.1537
MLA
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., Song, J."Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 7.4 (2014): 1045-1049.
Chicago
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., Song, J."Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 7, no. 4 (2014): 1045-1049. https://doi.org/10.3892/etm.2014.1537
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Fei P, Mu J, Wang H, Li W and Song J: Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model. Exp Ther Med 7: 1045-1049, 2014.
APA
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., & Song, J. (2014). Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model. Experimental and Therapeutic Medicine, 7, 1045-1049. https://doi.org/10.3892/etm.2014.1537
MLA
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., Song, J."Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 7.4 (2014): 1045-1049.
Chicago
Zhang, Z., Fei, P., Mu, J., Wang, H., Li, W., Song, J."Decreased expression of neuronal Per‑Arnt‑Sim domain protein 4 gene in the hippocampus of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 7, no. 4 (2014): 1045-1049. https://doi.org/10.3892/etm.2014.1537
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team