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2014-April Volume 7 Issue 4

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Article

Effects of resveratrol on apoptosis in a rat model of vascular dementia

  • Authors:
    • Zhi‑Kun Sun
    • Xing‑Rong Ma
    • Yan‑Jie Jia
    • Yan‑Ru Liu
    • Jie‑Wen Zhang
    • Bo‑Ai Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, Henan 450002, P.R. China, Department of Neurology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450002, P.R. China
  • Pages: 843-848
    |
    Published online on: February 13, 2014
       https://doi.org/10.3892/etm.2014.1542
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Abstract

Resveratrol is a natural polyphenol widely present in plants, particularly in the skin of red grapes and in wine. It possesses a wide range of biological effects and exhibits neuroprotective effects in numerous diseases. However, data evaluating the effects of resveratrol in vascular dementia (VaD) are lacking. In the present study, the permanent, bilateral common carotid artery occlusion rat model was used to study the effects of resveratrol on VaD. The Morris water maze was used to test the spatial learning and memory performance of the rats. The expression levels of Bax, Bcl‑2, cleaved caspase‑3 and cleaved poly(ADP‑ribose) polymerase (PARP) in the hippocampus were measured. The results showed that resveratrol inhibited memory impairment in the VaD rat model, and attenuated the increases in the expression levels of Bax, cleaved caspase‑3 and cleaved PARP and the reductions in the expression levels of Bcl‑2 that were induced by VaD. These results provide a novel insight into the neuroprotective effects of resveratrol and its possible therapeutic role in VaD.
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Copy and paste a formatted citation
Spandidos Publications style
Sun ZK, Ma XR, Jia YJ, Liu YR, Zhang JW and Zhang BA: Effects of resveratrol on apoptosis in a rat model of vascular dementia. Exp Ther Med 7: 843-848, 2014.
APA
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., & Zhang, B. (2014). Effects of resveratrol on apoptosis in a rat model of vascular dementia. Experimental and Therapeutic Medicine, 7, 843-848. https://doi.org/10.3892/etm.2014.1542
MLA
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., Zhang, B."Effects of resveratrol on apoptosis in a rat model of vascular dementia". Experimental and Therapeutic Medicine 7.4 (2014): 843-848.
Chicago
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., Zhang, B."Effects of resveratrol on apoptosis in a rat model of vascular dementia". Experimental and Therapeutic Medicine 7, no. 4 (2014): 843-848. https://doi.org/10.3892/etm.2014.1542
Copy and paste a formatted citation
x
Spandidos Publications style
Sun ZK, Ma XR, Jia YJ, Liu YR, Zhang JW and Zhang BA: Effects of resveratrol on apoptosis in a rat model of vascular dementia. Exp Ther Med 7: 843-848, 2014.
APA
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., & Zhang, B. (2014). Effects of resveratrol on apoptosis in a rat model of vascular dementia. Experimental and Therapeutic Medicine, 7, 843-848. https://doi.org/10.3892/etm.2014.1542
MLA
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., Zhang, B."Effects of resveratrol on apoptosis in a rat model of vascular dementia". Experimental and Therapeutic Medicine 7.4 (2014): 843-848.
Chicago
Sun, Z., Ma, X., Jia, Y., Liu, Y., Zhang, J., Zhang, B."Effects of resveratrol on apoptosis in a rat model of vascular dementia". Experimental and Therapeutic Medicine 7, no. 4 (2014): 843-848. https://doi.org/10.3892/etm.2014.1542
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