Effects of three blood purification methods on serum fibroblast growth factor‑23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis

  • Authors:
    • Li-Ying Miao
    • Bin Zhu
    • Xiao-Zhou He
    • Jin-Feng Liu
    • Li-Na Jin
    • Xiu‑Rong Li
    • Li-Na Xue
    • Tian Huang
    • Jian‑Qin Shen
    • Chang‑Ying Xing
  • View Affiliations

  • Published online on: February 13, 2014     https://doi.org/10.3892/etm.2014.1543
  • Pages: 947-952
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Abstract

The aim of the present study was to investigate the effects of three blood purification methods on fibroblast growth factor‑23 (FGF‑23) clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis (MHD). In addition, the correlation between serum FGF‑23 and phosphorus (Pi) levels and the clinical implications were identified. Sixty‑five MHD patients with hyperphosphatemia were randomly divided into three groups: Hemodialysis, HD (n=23); hemodiafiltration, HDF (n=21); and hemodialysis+hemoperfusion, HD+HP (n=21) groups. Serum Pi, FGF-23, blood urea nitrogen, serum creatinine and associated bio‑marker levels were measured prior to and following treatment. The expression level of serum FGF‑23 was observed to be positively correlated with Pi (r=0.45, P<0.01). The three blood purification methods that were adopted for the present study exhibited significant and effective clearance of serum Pi (P<0.05). The post-treatment serum FGF‑23 levels were significantly decreased in the HDF and HD+HP groups (P<0.05). Therefore, HDF may be an effective method for clearing serum FGF‑23 in MHD patients exhibiting hyperphosphatemia.
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2014-April
Volume 7 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Miao L, Zhu B, He X, Liu J, Jin L, Li XR, Xue L, Huang T, Shen JQ, Xing CY, Xing CY, et al: Effects of three blood purification methods on serum fibroblast growth factor‑23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis. Exp Ther Med 7: 947-952, 2014
APA
Miao, L., Zhu, B., He, X., Liu, J., Jin, L., Li, X. ... Xing, C. (2014). Effects of three blood purification methods on serum fibroblast growth factor‑23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis. Experimental and Therapeutic Medicine, 7, 947-952. https://doi.org/10.3892/etm.2014.1543
MLA
Miao, L., Zhu, B., He, X., Liu, J., Jin, L., Li, X., Xue, L., Huang, T., Shen, J., Xing, C."Effects of three blood purification methods on serum fibroblast growth factor‑23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis". Experimental and Therapeutic Medicine 7.4 (2014): 947-952.
Chicago
Miao, L., Zhu, B., He, X., Liu, J., Jin, L., Li, X., Xue, L., Huang, T., Shen, J., Xing, C."Effects of three blood purification methods on serum fibroblast growth factor‑23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis". Experimental and Therapeutic Medicine 7, no. 4 (2014): 947-952. https://doi.org/10.3892/etm.2014.1543