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Article

Transthyretin as a novel candidate biomarker for preeclampsia

  • Authors:
    • Lei Zhu
    • Yuxuan Chen
    • Chongdong Liu
    • Haiteng Deng
    • Nawei Zhang
    • Shengdian Wang
    • Zhenyu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, P.R. China, The Rockefeller University, New York, NY 10065, USA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China
  • Pages: 1332-1336
    |
    Published online on: February 18, 2014
       https://doi.org/10.3892/etm.2014.1558
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Abstract

Preeclampsia (PE) is considered to be a potentially fatal complication during pregnancy. However, no effective laboratory assessment has been developed to enable early diagnosis and monitoring of PE. The present study aimed to identify differentially expressed transthyretin (TTR) during severe PE and evaluate TTR as a possible biomarker of this disease. TTR levels were determined in the different gestational weeks of normal pregnancy (before 20 weeks, n=41; after 20 weeks, n=39) using enzyme‑linked immunosorbent assay (ELISA). TTR concentrations in pregnant females with severe PE (n=43) were compared with those in healthy matched control subjects (n=37) using western blot analysis and ELISA. The median TTR concentration during severe PE in each month of gestation was significantly lower than the concentrations recorded during normal pregnancy. TTR levels in females with severe PE were significantly downregulated compared with the control subjects (P<0.001; area under the curve, 0.834‑0.967). Thus, TTR may be used as a potential biomarker of PE.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Chen Y, Liu C, Deng H, Zhang N, Wang S and Zhang Z: Transthyretin as a novel candidate biomarker for preeclampsia. Exp Ther Med 7: 1332-1336, 2014.
APA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., & Zhang, Z. (2014). Transthyretin as a novel candidate biomarker for preeclampsia. Experimental and Therapeutic Medicine, 7, 1332-1336. https://doi.org/10.3892/etm.2014.1558
MLA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7.5 (2014): 1332-1336.
Chicago
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1332-1336. https://doi.org/10.3892/etm.2014.1558
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Chen Y, Liu C, Deng H, Zhang N, Wang S and Zhang Z: Transthyretin as a novel candidate biomarker for preeclampsia. Exp Ther Med 7: 1332-1336, 2014.
APA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., & Zhang, Z. (2014). Transthyretin as a novel candidate biomarker for preeclampsia. Experimental and Therapeutic Medicine, 7, 1332-1336. https://doi.org/10.3892/etm.2014.1558
MLA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7.5 (2014): 1332-1336.
Chicago
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1332-1336. https://doi.org/10.3892/etm.2014.1558
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