Transthyretin as a novel candidate biomarker for preeclampsia

  • Authors:
    • Lei Zhu
    • Yuxuan Chen
    • Chongdong Liu
    • Haiteng Deng
    • Nawei Zhang
    • Shengdian Wang
    • Zhenyu Zhang
  • View Affiliations

  • Published online on: February 18, 2014     https://doi.org/10.3892/etm.2014.1558
  • Pages: 1332-1336
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Abstract

Preeclampsia (PE) is considered to be a potentially fatal complication during pregnancy. However, no effective laboratory assessment has been developed to enable early diagnosis and monitoring of PE. The present study aimed to identify differentially expressed transthyretin (TTR) during severe PE and evaluate TTR as a possible biomarker of this disease. TTR levels were determined in the different gestational weeks of normal pregnancy (before 20 weeks, n=41; after 20 weeks, n=39) using enzyme‑linked immunosorbent assay (ELISA). TTR concentrations in pregnant females with severe PE (n=43) were compared with those in healthy matched control subjects (n=37) using western blot analysis and ELISA. The median TTR concentration during severe PE in each month of gestation was significantly lower than the concentrations recorded during normal pregnancy. TTR levels in females with severe PE were significantly downregulated compared with the control subjects (P<0.001; area under the curve, 0.834‑0.967). Thus, TTR may be used as a potential biomarker of PE.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu L, Chen Y, Liu C, Deng H, Zhang N, Wang S and Zhang Z: Transthyretin as a novel candidate biomarker for preeclampsia. Exp Ther Med 7: 1332-1336, 2014
APA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., & Zhang, Z. (2014). Transthyretin as a novel candidate biomarker for preeclampsia. Experimental and Therapeutic Medicine, 7, 1332-1336. https://doi.org/10.3892/etm.2014.1558
MLA
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7.5 (2014): 1332-1336.
Chicago
Zhu, L., Chen, Y., Liu, C., Deng, H., Zhang, N., Wang, S., Zhang, Z."Transthyretin as a novel candidate biomarker for preeclampsia". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1332-1336. https://doi.org/10.3892/etm.2014.1558