Preventive effects of basic fibroblast growth factor on vascular restenosis after balloon angioplasty

Ran,Feng; Liu,Changjian; Liu,Zhao; Shang,Tao; Zhou,Min; Qiao,Tong

doi:10.3892/etm.2014.1562

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Preventive effects of basic fibroblast growth factor on vascular restenosis after balloon angioplasty

Authors:
- Feng Ran
- Changjian Liu
- Zhao Liu
- Tao Shang
- Min Zhou
- Tong Qiao
View Affiliations / Copyright

Affiliations: Department of Vascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
Pages: 1193-1196
|
Published online on: February 19, 2014

https://doi.org/10.3892/etm.2014.1562
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Abstract

The aim of the present study was to investigate whether chronic administration of basic fibroblast growth factor (bFGF) following angioplasty in a dog model of atherosclerotic iliac stenosis may restore endothelium function and prevent restenosis (RS). In total, 40 dogs with atherosclerotic stenosis of the right iliac arteries were used in the study. A total of 20 dogs underwent histological examination of the lumen areas prior to (n=10) and immediately following angioplasty (n=10). Intravenous bFGF was administered to 10 dogs (bFGF group) and an additional 10 dogs received vehicle injection (control group). Animals in the two groups were sacrificed 42 days following surgery for in vitro analysis of vascular reactivity and morphometric assessment of the histological cross‑sectional areas. The bFGF group exhibited significantly greater maximal endothelium‑dependent acetylcholine-induced relaxation (Emax, 43±9%) when compared with the control group (Emax, 8±6%; P<0.05). In addition, the maximal endothelium-independent response of the bFGF group to sodium nitroprusside (Emax, 90±2%) was greater than that of the control group (Emax, 60±2%; P<0.05). Six weeks following angioplasty, the lumen area in the bFGF group (2.01±0.78 mm2) was greater compared with the control group (1.0±0.10%). The lumen area decreased by 58% between immediately after angioplasty and the control group six weeks following angioplasty. Therefore, the results of the present study indicated that administration of bFGF may not only restore endothelium‑dependent and ‑independent relaxation, but also prevent RS in dogs that have undergone angioplasty.

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1	Kibos A, Campeanu A and Tintoiu I: Pathophysiology of coronary artery in-stent restenosis. Acute Card Care. 9:111–119. 2007. View Article : Google Scholar : PubMed/NCBI
2	Zargham R: Preventing restenosis after angioplasty: a multistage approach. Clin Sci (Lond). 114:257–264. 2008. View Article : Google Scholar : PubMed/NCBI
3	Xie C, Guo Y, Zhu T, Zhang J, Ma PX and Chen YE: Yap1 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. J Biol Chem. 287:14598–14605. 2012. View Article : Google Scholar : PubMed/NCBI
4	Mulder HJ, Schalij MJ, Kauer B, et al: Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial. Heart. 86:533–539. 2001. View Article : Google Scholar : PubMed/NCBI
5	Pozo M, Izquierdo MC, de Nicolás R, Egido J, Ortiz A and González-Cabrero J: Gliotoxin inhibits neointimal hyperplasia after vascular injury in rats. J Vasc Res. 46:278–289. 2009. View Article : Google Scholar : PubMed/NCBI
6	Weakley SM, Wang X, Mu H, et al: Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 171:31–39. 2011. View Article : Google Scholar : PubMed/NCBI
7	Segev A, Aviezer D, Safran M, Gross Z and Yayon A: Inhibition of vascular smooth muscle cell proliferation by a novel fibroblast growth factor receptor antagonist. Cardiovasc Res. 53:232–241. 2002. View Article : Google Scholar : PubMed/NCBI
8	Majesky MW, Dong XR, Hoglund V, Daum G and Mahoney WM Jr: The adventitia: a progenitor cell niche for the vessel wall. Cells Tissues Organs. 195:73–81. 2012. View Article : Google Scholar : PubMed/NCBI
9	Song Z, Jin R, Yu S, Nanda A, Granger DN and Li G: Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions. Arterioscler Thromb Vasc Biol. 32:50–64. 2012. View Article : Google Scholar : PubMed/NCBI
10	Chadjichristos CE, Matter CM, Roth I, et al: Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation. 113:2835–2843. 2006. View Article : Google Scholar : PubMed/NCBI
11	Makiyama Y, Toba K, Kato K, et al: Imatinib mesilate inhibits neointimal hyperplasia via growth inhibition of vascular smooth muscle cells in a rat model of balloon injury. Tohoku J Exp Med. 215:299–306. 2008. View Article : Google Scholar : PubMed/NCBI
12	Sadowitz B, Seymour K, Gahtan V and Maier KG: The role of hyaluronic acid in atherosclerosis and intimal hyperplasia. J Surg Res. 173:63–72. 2012. View Article : Google Scholar
13	Backes A, Seay U, Sedding DG, Tillmanns HH and Braun-Dullaeus RC: Inhibition of matrix deposition: a new strategy for prevention of restenosis after balloon angioplasty. J Cardiovasc Pharmacol. 55:213–218. 2010. View Article : Google Scholar : PubMed/NCBI
14	Cooney R, Hynes SO, Sharif F, Howard L and O’Brien T: Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury. Gene Ther. 14:396–404. 2007. View Article : Google Scholar : PubMed/NCBI
15	Mnjoyan ZH, Doan D, Brandon JL, et al: The critical role of the intrinsic VSMC proliferation and death programs in injury-induced neointimal hyperplasia. Am J Physiol Heart Circ Physiol. 294:H2276–H2284. 2008. View Article : Google Scholar : PubMed/NCBI
16	Yao EH, Fukuda N, Ueno T, et al: A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery. Cardiovasc Res. 81:797–804. 2009. View Article : Google Scholar
17	Indolfi C, Torella D, Coppola C, et al: Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats. Circ Res. 91:1190–1197. 2002. View Article : Google Scholar : PubMed/NCBI
18	Malabanan KP, Kanellakis P, Bobik A and Khachigian LM: Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury. Circ Res. 103:378–387. 2008. View Article : Google Scholar
19	Cheng B, Fu X and Sheng Z: Effect of exogenous basic fibroblast growth factor on proliferation and migration of endothelial cells of partial thickness scald in rats. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 18:200–204. 2004.(In Chinese).
20	Chang L, Zhang C, Wu YJ and Zhu RZ: Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats. Acta Pharmacol Sin. 22:876–880. 2001.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Preventive effects of basic fibroblast growth factor on vascular restenosis after balloon angioplasty

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