Association between pelvic organ prolapse and stress urinary incontinence with collagen

  • Authors:
    • Liying Han
    • Ling Wang
    • Qiang Wang
    • Helian Li
    • Hu Zang
  • View Affiliations

  • Published online on: February 20, 2014     https://doi.org/10.3892/etm.2014.1563
  • Pages: 1337-1341
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Abstract

The aim of the present study was to investigate the ultrastructure and content of collagen in uterosacral ligaments and paraurethral tissues in patients with pelvic organ prolapse (POP) and stress urinary incontinence (SUI), analyzing the association between POP and collagen dysfunction. The study comprised three groups: Control, POP and POP with SUI (n=30 per group). Histological characteristics of collagen fiber were observed and the diameters were measured using light and electron microscopy to determine the Type I and Type III collagen content of the main ligament in the urethral specimens. In the POP and POP with SUI groups, observations included diffuse atrophy of smooth muscles, active fibroblast metabolism, swollen mitochondria and visible Golgi apparatus. The collagen fibril diameters in the cardinal ligaments, uterosacral ligaments and paraurethral tissues were significantly greater in the POP and POP with SUI groups compared with those in the control group (P<0.01). In addition, the expression levels of Type I and Type III collagen were significantly lower in the POP and POP with SUI groups when compared with the control group (P<0.01). In the POP with SUI group, pelvic tissues were frail, resulting in smooth muscle bundles comminuting and arranging in a disorganized pattern. Fibroblast and myoblast metabolisms were active and new microvascular cells were weak. However, the collagen fibril diameter increased. Thus, collagen and ultrastructural changes in the pelvic floor may be associated with the development of POP and SUI.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han L, Wang L, Wang Q, Li H and Zang H: Association between pelvic organ prolapse and stress urinary incontinence with collagen. Exp Ther Med 7: 1337-1341, 2014
APA
Han, L., Wang, L., Wang, Q., Li, H., & Zang, H. (2014). Association between pelvic organ prolapse and stress urinary incontinence with collagen. Experimental and Therapeutic Medicine, 7, 1337-1341. https://doi.org/10.3892/etm.2014.1563
MLA
Han, L., Wang, L., Wang, Q., Li, H., Zang, H."Association between pelvic organ prolapse and stress urinary incontinence with collagen". Experimental and Therapeutic Medicine 7.5 (2014): 1337-1341.
Chicago
Han, L., Wang, L., Wang, Q., Li, H., Zang, H."Association between pelvic organ prolapse and stress urinary incontinence with collagen". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1337-1341. https://doi.org/10.3892/etm.2014.1563