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Article

Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells

  • Authors:
    • Zuo‑Lin Ying
    • Xiao‑Jie Li
    • Hong Dang
    • Feng Wang
    • Xiao‑Yan Xu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Experimental Research Center, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China
  • Pages: 1354-1358
    |
    Published online on: February 20, 2014
       https://doi.org/10.3892/etm.2014.1568
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Abstract

Saikosaponin‑d (Ssd) is a triterpenoid saponin derived from Bupleurum falcatum L., which has been shown to exhibit a variety of pharmacological properties, including anti‑inflammatory, antibacterial and antiviral properties. The aim of the present study was to investigate the effect of Ssd on the differentiation, maturation and function of human monocyte‑derived dendritic cells (DCs) isolated from condylomata acuminata patients. The results of the present study demonstrated that Ssd reduced the differentiation of DCs, as evidenced by decreased expression levels of cluster of differentiation (CD)1a, CD80 and CD86 molecules and increased CD14 expression. Expression levels of the mannose receptor and CD32 were also significantly elevated, which was associated with enhanced fluorescein isothiocyanate‑dextran endocytic activity. Furthermore, Ssd treatment promoted DC maturation by increasing the expression levels of CD40, CD83, CD80 and CD86. In addition, the function of mature DCs, including the secretion of IL‑12 and the stimulation of lymphocyte proliferation, was significantly increased following Ssd administration. In conclusion, the present study indicated that Ssd exhibited immunomodulatory effects and may be a novel potent chemopreventive drug candidate for the treatment of condylomata acuminata.
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Copy and paste a formatted citation
Spandidos Publications style
Ying ZL, Li XJ, Dang H, Wang F and Xu XY: Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells. Exp Ther Med 7: 1354-1358, 2014.
APA
Ying, Z., Li, X., Dang, H., Wang, F., & Xu, X. (2014). Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells. Experimental and Therapeutic Medicine, 7, 1354-1358. https://doi.org/10.3892/etm.2014.1568
MLA
Ying, Z., Li, X., Dang, H., Wang, F., Xu, X."Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells". Experimental and Therapeutic Medicine 7.5 (2014): 1354-1358.
Chicago
Ying, Z., Li, X., Dang, H., Wang, F., Xu, X."Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1354-1358. https://doi.org/10.3892/etm.2014.1568
Copy and paste a formatted citation
x
Spandidos Publications style
Ying ZL, Li XJ, Dang H, Wang F and Xu XY: Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells. Exp Ther Med 7: 1354-1358, 2014.
APA
Ying, Z., Li, X., Dang, H., Wang, F., & Xu, X. (2014). Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells. Experimental and Therapeutic Medicine, 7, 1354-1358. https://doi.org/10.3892/etm.2014.1568
MLA
Ying, Z., Li, X., Dang, H., Wang, F., Xu, X."Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells". Experimental and Therapeutic Medicine 7.5 (2014): 1354-1358.
Chicago
Ying, Z., Li, X., Dang, H., Wang, F., Xu, X."Saikosaponin‑d affects the differentiation, maturation and function of monocyte‑derived dendritic cells". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1354-1358. https://doi.org/10.3892/etm.2014.1568
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