Effectiveness and safety profile of S‑1‑based chemotherapy compared with capecitabine‑based chemotherapy for advanced gastric and colorectal cancer: A meta‑analysis

  • Authors:
    • Jia-Xiang Ye
    • Ai-Qun Liu
    • Lian-Ying Ge
    • Shao-Zhang Zhou
    • Zhong‑Guo Liang
  • View Affiliations

  • Published online on: February 24, 2014     https://doi.org/10.3892/etm.2014.1576
  • Pages: 1271-1278
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Abstract

The aim of the present analysis was to compare the efficacy and safety profile of S‑1‑based chemotherapy (SBCT) versus capecitabine‑based chemotherapy (CBCT) for advanced gastric cancer (AGC) and advanced colorectal cancer (ACRC). A meta‑analysis was performed, which included eligible randomized controlled trials (RCTs) that were identified using RevMan 5.1.0 software. A total of 1,064 patients from 11 RCTs, comprising of 527 patients in the SBCT group and 537 patients in the CBCT group, were included in the analysis. For AGC, the meta‑analysis of overall survival (OS) [hazard ratio (HR), 0.98; 95% confidence interval (CI), 0.85‑1.12], time to progression (HR, 0.95; 95% CI, 0.80‑1.12) and overall response rate (ORR) [odds ratio (OR), 1.06; 95% CI, 0.72-1.55] of patients in the SBCT group indicated no statistical significance when compared with those in the CBCT group. Furthermore, for ACRC, a pooled analysis demonstrated no significant difference between the SBCT and CBCT groups (OS: HR, 0.82; 95% CI, 0.61-1.10; progression-free survival: HR, 0.79; 95% CI=0.60‑1.04; ORR: OR, 1.27; 95% CI, 0.91‑1.78). The statistically significant differences identified in the overall meta‑analysis indicated a low incidence of grade 3-4 hand‑foot‑syndrome (OR, 0.15; 95% CI, 0.06‑0.36) in the SBCT group; however no statistically significant difference was observed in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, neutropenia, diarrhea, stomatitis or nausea/vomiting. The SBCT treatment exhibited similar efficacy and an approximately equivalent safety profile compared with the CBCT treatment and was an alternative to CBCT for patients with AGC or ACRC; however, further investigation is required to provide confirmation.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ye J, Liu A, Ge L, Zhou S and Liang ZG: Effectiveness and safety profile of S‑1‑based chemotherapy compared with capecitabine‑based chemotherapy for advanced gastric and colorectal cancer: A meta‑analysis. Exp Ther Med 7: 1271-1278, 2014.
APA
Ye, J., Liu, A., Ge, L., Zhou, S., & Liang, Z. (2014). Effectiveness and safety profile of S‑1‑based chemotherapy compared with capecitabine‑based chemotherapy for advanced gastric and colorectal cancer: A meta‑analysis. Experimental and Therapeutic Medicine, 7, 1271-1278. https://doi.org/10.3892/etm.2014.1576
MLA
Ye, J., Liu, A., Ge, L., Zhou, S., Liang, Z."Effectiveness and safety profile of S‑1‑based chemotherapy compared with capecitabine‑based chemotherapy for advanced gastric and colorectal cancer: A meta‑analysis". Experimental and Therapeutic Medicine 7.5 (2014): 1271-1278.
Chicago
Ye, J., Liu, A., Ge, L., Zhou, S., Liang, Z."Effectiveness and safety profile of S‑1‑based chemotherapy compared with capecitabine‑based chemotherapy for advanced gastric and colorectal cancer: A meta‑analysis". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1271-1278. https://doi.org/10.3892/etm.2014.1576