Effect of Quanzhenyiqitang on apoptosis of alveolar macrophages and expression of histone deacetylase 2 in rats with chronic obstructive pulmonary disease

Li,Da‑Zhi; Ruan,Shi‑Wei; Chen,Zhi‑Bin; Wang,Chun-E.

doi:10.3892/etm.2014.1585

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Effect of Quanzhenyiqitang on apoptosis of alveolar macrophages and expression of histone deacetylase 2 in rats with chronic obstructive pulmonary disease

Authors:
- Da‑Zhi Li
- Shi‑Wei Ruan
- Zhi‑Bin Chen
- Chun-E. Wang
View Affiliations / Copyright

Affiliations: Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350000, P.R. China, Medical Center of the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350000, P.R. China, The Fujian Research Academy of Traditional Chinese Medicine, Fuzhou, Fujian 350000, P.R. China, Department of Respiration, The Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350000, P.R. China
Pages: 1327-1331
|
Published online on: February 25, 2014

https://doi.org/10.3892/etm.2014.1585
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Abstract

This study aimed to investigate the effect of Quanzhenyiqitang on alveolar macrophages (AMs) in a rat model of chronic obstructive pulmonary disease (COPD). In addition, the induction of apoptosis and regulation of histone deacetylase 2 (HDAC2) was studied to elucidate the underlying mechanisms of Quanzhenyiqitang treatment of COPD. Quanzhenyiqitang‑treated serum was applied to AMs obtained from rats with COPD. A blank (control) group, an untreated serum group and an aminophylline group were also observed to evaluate the differences in AM apoptosis status, as well as the expression levels of caspase‑9, caspase‑8 and HDAC2. Compared with the control group, Quanzhenyiqitang‑treated serum resulted in higher levels of caspase‑9 and caspase‑8 expression, increased apoptosis of AMs and increased expression of HDAC2 by AMs. In conclusion, Quanzhenyiqitang is capable of inducing apoptosis of AMs, which are the primary inflammatory cells in COPD, and modulating the expression of the important inflammatory factor HDAC2, producing an overall anti‑inflammatory effect.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of Quanzhenyiqitang on apoptosis of alveolar macrophages and expression of histone deacetylase 2 in rats with chronic obstructive pulmonary disease

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