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Article

Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury

  • Authors:
    • Bingzhou Cui
    • En Li
    • Bo Yang
    • Bo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Zhengzhou People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Neurosurgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450003, P.R. China
  • Pages: 1233-1236
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/etm.2014.1608
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Abstract

The aim of the present study was to investigate the effects of human umbilical cord blood‑derived mesenchymal stem cell (HUCB‑MSC) transplantation on the functional restoration of spinal cord injury (SCI). A total of 46 adult Wistar rats were randomly divided into three groups: Injury (n=15), control (n=15) and transplantation (n=16). A SCI model was established using the modified Allen's method (vulnerating energy, 25 g/cm). The rats in the control and transplantation groups were injected at the site of the injury with physiological saline and HUCB-MSC suspension, respectively. At week one, two and four following treatment, the behavior of the rats was evaluated using the Basso, Beattie, Bresnahan locomotor rating scale. In addition, immunohistochemistry (IHC) was performed on samples from the rats that had been sacrificed four weeks subsequent to the treatment. Recovery of the spinal cord nerve function was identified to be significantly different at week two and four following treatment (P<0.05), and IHC identified that at week four following treatment novel nerve cells were being produced. Thus, transplantation of HUCB‑MSCs promoted the recovery of the damaged function of spinal cord nerves in rats with SCI.
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Copy and paste a formatted citation
Spandidos Publications style
Cui B, Li E, Yang B and Wang B: Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury. Exp Ther Med 7: 1233-1236, 2014.
APA
Cui, B., Li, E., Yang, B., & Wang, B. (2014). Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury. Experimental and Therapeutic Medicine, 7, 1233-1236. https://doi.org/10.3892/etm.2014.1608
MLA
Cui, B., Li, E., Yang, B., Wang, B."Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury". Experimental and Therapeutic Medicine 7.5 (2014): 1233-1236.
Chicago
Cui, B., Li, E., Yang, B., Wang, B."Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1233-1236. https://doi.org/10.3892/etm.2014.1608
Copy and paste a formatted citation
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Spandidos Publications style
Cui B, Li E, Yang B and Wang B: Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury. Exp Ther Med 7: 1233-1236, 2014.
APA
Cui, B., Li, E., Yang, B., & Wang, B. (2014). Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury. Experimental and Therapeutic Medicine, 7, 1233-1236. https://doi.org/10.3892/etm.2014.1608
MLA
Cui, B., Li, E., Yang, B., Wang, B."Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury". Experimental and Therapeutic Medicine 7.5 (2014): 1233-1236.
Chicago
Cui, B., Li, E., Yang, B., Wang, B."Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1233-1236. https://doi.org/10.3892/etm.2014.1608
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