Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

  • Authors:
    • Da Shi
    • Yindi Sun
    • Jichao Yin
    • Xiaochen Fan
    • Honghao Duan
    • Na Liu
    • Wei He
  • View Affiliations

  • Published online on: March 14, 2014     https://doi.org/10.3892/etm.2014.1622
  • Pages: 1471-1475
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Abstract

The aim of the present study was to observe the curative effect of traditional Chinese cajan leaves, combined with administration of bone marrow‑derived mesenchymal stem cells (BMSCs), on osteonecrosis of the femoral head (ONFH) in rats and to investigate the underlying mechanisms. A total of 40 rat ONFH models were established through liquid nitrogen freezing and were subsequently divided into groups: A, control; B, treated with cajan leaf; C, treated with BMSCs and D, treated with cajan leaf combined with BMSCs. Samples were obtained 30 days following treatment, and immunohistochemical staining of vascular endothelial growth factor (VEGF) and image analysis were performed. Chondrocytes and vascular endothelial cells were stained as a result of immunohistochemical staining and group D exhibited markedly deeper staining, and a significantly larger number of stained cells, compared with group A. Thus, in the present study, cajan leaf combined with BMSCs was shown to promote VEGF expression and improve ONFH repair.
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June-2014
Volume 7 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shi D, Sun Y, Yin J, Fan X, Duan H, Liu N and He W: Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head. Exp Ther Med 7: 1471-1475, 2014
APA
Shi, D., Sun, Y., Yin, J., Fan, X., Duan, H., Liu, N., & He, W. (2014). Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head. Experimental and Therapeutic Medicine, 7, 1471-1475. https://doi.org/10.3892/etm.2014.1622
MLA
Shi, D., Sun, Y., Yin, J., Fan, X., Duan, H., Liu, N., He, W."Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 7.6 (2014): 1471-1475.
Chicago
Shi, D., Sun, Y., Yin, J., Fan, X., Duan, H., Liu, N., He, W."Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1471-1475. https://doi.org/10.3892/etm.2014.1622