Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

Shi,Da; Sun,Yindi; Yin,Jichao; Fan,Xiaochen; Duan,Honghao; Liu,Na; He,Wei

doi:10.3892/etm.2014.1622

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Article

Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

Authors:
- Da Shi
- Yindi Sun
- Jichao Yin
- Xiaochen Fan
- Honghao Duan
- Na Liu
- Wei He
View Affiliations / Copyright

Affiliations: Department of Orthopedics of Traditional Chinese Medicine, Hong Hui Hospital Affiliated to Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710054, P.R. China, Department of Orthopedics of Traditional Chinese Medicine, Hong Hui Hospital Affiliated to Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710054, P.R. China, Department of Orthopedics, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China
Pages: 1471-1475
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Published online on: March 14, 2014

https://doi.org/10.3892/etm.2014.1622
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Abstract

The aim of the present study was to observe the curative effect of traditional Chinese cajan leaves, combined with administration of bone marrow‑derived mesenchymal stem cells (BMSCs), on osteonecrosis of the femoral head (ONFH) in rats and to investigate the underlying mechanisms. A total of 40 rat ONFH models were established through liquid nitrogen freezing and were subsequently divided into groups: A, control; B, treated with cajan leaf; C, treated with BMSCs and D, treated with cajan leaf combined with BMSCs. Samples were obtained 30 days following treatment, and immunohistochemical staining of vascular endothelial growth factor (VEGF) and image analysis were performed. Chondrocytes and vascular endothelial cells were stained as a result of immunohistochemical staining and group D exhibited markedly deeper staining, and a significantly larger number of stained cells, compared with group A. Thus, in the present study, cajan leaf combined with BMSCs was shown to promote VEGF expression and improve ONFH repair.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cajan leaf combined with bone marrow‑derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

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