A novel animal model of osteonecrosis of the femoral head induced using a magnetic resonance imaging‑guided argon‑helium cryotherapy system

Wang,Dong; Wang,Guowei; Liu,Ming; Sun,Lixin; Zong,Wei; Jiang,Honglei; Zhang,Huawu; Li,Huibo; Gong,Jianbao; Sun,Shui

doi:10.3892/etm.2014.1625

June-2014 Volume 7 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June-2014 Volume 7 Issue 6

Full Size Image

Article

A novel animal model of osteonecrosis of the femoral head induced using a magnetic resonance imaging‑guided argon‑helium cryotherapy system

Authors:
- Dong Wang
- Guowei Wang
- Ming Liu
- Lixin Sun
- Wei Zong
- Honglei Jiang
- Huawu Zhang
- Huibo Li
- Jianbao Gong
- Shui Sun
View Affiliations / Copyright

Affiliations: Department of Orthopedics, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Orthopedics, Shandong Jiaotong Hospital, Shandong University, Jinan, Shandong 250031, P.R. China, Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
Pages: 1525-1528
|
Published online on: March 14, 2014

https://doi.org/10.3892/etm.2014.1625
Expand metrics +

Abstract

The aim of the present study was to establish a novel animal model of osteonecrosis of the femoral head (ONFH) using a magnetic resonance imaging (MRI)‑guided argon‑helium cryotherapy system. A total of 48 rabbits were used to generate the ONFH models. In group I, the left femoral head of the rabbits received two cycles of argon‑helium freezing‑thawing under MRI guidance, while in group II, the right femoral head of each rabbit received only one cycle of argon‑helium freezing‑thawing. X‑ray and histological examinations were performed. The percentages of lacunae in the femoral heads of group I at weeks 4, 8 and 12 following surgery (49.75±3.17, 62.06±4.12 and 48.25±2.76%, respectively) were higher than those in group II (39.13±4.48, 50.69±3.84 and 37.50±3.86%, respectively). In addition, the percentage of empty lacunae in group I was 62.06% at week 8 following surgery. Therefore, an animal model of ONFH was successfully established using an argon‑helium cryotherapy system. The percentage of empty lacunae in group I was higher than that in group II at weeks 4, 8 and 12 after surgery.

View Figures

View References

1	Etienne G, Mont MA and Ragland PS: The diagnosis and treatment of nontraumatic osteonecrosis of the femoral head. Instr Course Lect. 53:67–85. 2004.PubMed/NCBI
2	Mont MA, Carbone JJ and Fairbank AC: Core decompression versus nonoperative management for osteonecrosis of the hip. Clin Orthop Relat Res. 324:169–178. 1996. View Article : Google Scholar : PubMed/NCBI
3	Choy WS, Kim KJ, Lee SK, et al: Ceramic-on-ceramic total hip arthroplasty: minimum of six-year follow-up study. Clin Orthop Surg. 5:174–179. 2013.PubMed/NCBI
4	Gao YS, Chen SB, Jin DX, et al: Modified surgical techniques of free vascularized fibular grafting for treatment of the osteonecrosis of femoral head: Results from a series of 407 cases. Microsurgery. Aug 1–2013.(Epub ahead of print). View Article : Google Scholar
5	Lieberman JR, Berry DJ, Mont MA, et al: Osteonecrosis of the hip: management in the 21st century. Instr Course Lect. 52:337–355. 2003.PubMed/NCBI
6	Mont MA and Hungerford DS: Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 77:459–474. 1995.PubMed/NCBI
7	Takaoka K, Yoshioka T, Hosoya T, et al: The repair process in experimentally induced avascular necrosis of the femoral head in dogs. Arch Orthop Trauma Surg. 99:109–115. 1981. View Article : Google Scholar : PubMed/NCBI
8	Cetik O, Cift H, Comert B and Cirpar M: Risk of osteonecrosis of the femoral condyle after arthroscopic chondroplasty using radiofrequency: a prospective clinical series. Knee Surg Sports Traumatol Arthrosc. 17:24–29. 2009. View Article : Google Scholar : PubMed/NCBI
9	Bonutti PM, Seyler TM, Delanois RE, et al: Osteonecrosis of the knee after laser or radiofrequency-assisted arthroscopy: treatment with minimally invasive knee arthroplasty. J Bone Joint Surg Am. 88(Suppl 3): 69–75. 2006. View Article : Google Scholar : PubMed/NCBI
10	Li Y, Han R, Geng C, et al: A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop. 33:573–580. 2009. View Article : Google Scholar : PubMed/NCBI
11	Fan M, Peng J, Wang A, et al: Emu model of full-range femoral head osteonecrosis induced focally by an alternating freezing and heating insult. J Int Med Res. 39:187–198. 2011. View Article : Google Scholar : PubMed/NCBI
12	Yanagawa B, Holmes SD, Henry L, Hunt S and Ad N: Outcome of concomitant Cox-maze III procedure using an argon-based cryosurgical system: a single-center experience with 250 patients. Ann Thorac Surg. 95:1633–1639. 2013. View Article : Google Scholar : PubMed/NCBI
13	Albåge A, Péterffy M and Källner G: Learning what works in surgical cryoablation of atrial fibrillation: results of different application techniques and benefits of prospective follow-up. Interact Cardiovasc Thorac Surg. 13:480–484. 2011.PubMed/NCBI
14	Ad N, Henry L and Hunt S: The concomitant cryosurgical Cox-maze procedure using argon based cryoprobes: 12 month results. J Cardiovasc Surg (Torino). 52:593–599. 2011.PubMed/NCBI
15	Wu B, Xiao YY, Zhang X, Zhao L and Carrino JA: CT-guided percutaneous cryoablation of osteoid osteoma in children: an initial study. Skeletal Radiol. 40:1303–1310. 2011. View Article : Google Scholar : PubMed/NCBI
16	Robinson D, Halperin N and Nevo Z: Two freezing cycles ensure interface sterilization by cryosurgery during bone tumor resection. Cryobiology. 43:4–10. 2001. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A novel animal model of osteonecrosis of the femoral head induced using a magnetic resonance imaging‑guided argon‑helium cryotherapy system

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles