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Article

Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats

  • Authors:
    • Ming‑Wei Liu
    • Mei‑Xian Su
    • Lan‑Fang Qin
    • Xu Liu
    • Mao‑Li Tian
    • Wei Zhang
    • Yun-Hui Wang
  • View Affiliations / Copyright

    Affiliations: The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Surgical Intensive Care Unit, The Second Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650106, P.R. China, Department of Infectious Diseases, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650051, P.R. China
  • Pages: 1446-1456
    |
    Published online on: March 21, 2014
       https://doi.org/10.3892/etm.2014.1629
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Abstract

Successful drug treatment for sepsis‑related acute lung injury (ALI) remains a major clinical problem. Thus, the aim of the present study was to investigate the beneficial effects of salidroside on ameliorating cecal ligation and puncture (CLP)‑induced lung inflammation. Rats underwent CLP surgery to induce ALI and 800 mg/kg salidroside (i.v.) was administered 24 h after the CLP challenge. Subsequently, biochemical changes in the blood and lung tissues, as well as morphological and histological alterations in the lungs, that were associated with inflammation and injury were analysed. CLP was shown to significantly increase the serum levels of plasma tumour necrosis factor‑α and interleukin‑6, ‑1β and‑10. In addition, CLP increased pulmonary oedema, thickened the alveolar septa and caused inflammation in the lung cells. These changes were ameliorated by the administration of 800 mg/kg salidroside (i.v.) 24 h after the CLP challenge. This post‑treatment drug administration also significantly attenuated the lipopolysaccharide‑induced activation of nuclear factor‑κβ and increased the release of peroxisome proliferator‑activated receptor γ in the lung tissue. Therefore, salidroside administered following the induction of ALI by CLP significantly prevented and reversed lung tissue injuries. The positive post‑treatment effects of salidroside administration indicated that salidroside may be a potential candidate for the management of lung inflammation in CLP‑induced endotoxemia and septic shock.
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View References

1 

Ware LB and Matthay MA: The acute respiratory distress syndrome. N Engl J Med. 342:1334–1349. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ and Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med. 353:1685–1693. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Berthiaume Y, Folkesson HG and Matthay MA: Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol (1985). 93:2207–2213. 2002.PubMed/NCBI

4 

Eaton DC, Helms MN, Koval M, Bao HF and Jain L: The contribution of epithelial sodium channels to alveolar function in health and disease. Annu Rev Physiol. 71:403–423. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Morty RE, Eickelberg O and Seeger W: Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies? Intensive Care Med. 33:1229–1240. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Magnotti LJ, Upperman JS, Xu DZ, Lu Q and Deitch EA: Gut-derived mesenteric lymph but not portal blood increases endothelial permeability and promotes lung injury after hemorrhagic shock. Ann Surg. 228:518–527. 1998. View Article : Google Scholar

7 

Gupta N, Su X, Popov B, Lee JW, Serikov V and Matthay MA: Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 179:1855–1863. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Zhong H, Xin H, Wu LX and Zhu YZ: Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci. 114:399–408. 2010. View Article : Google Scholar

9 

Zhao Y, Ling Y, Zhao J, Yuan Y, Guo Y, Liu Q, Wu B, Ding Z and Yang Y: Synthesis and protective effects of novel salidroside analogues on glucose and serum depletion induced apoptosis in PC12 cells. Arch Pharm (Weinheim). 346:300–307. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Hu X, Lin S, Yu D, Qiu S, Zhang X and Mei R: A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol. 26:499–507. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Lin SS, Chin LW, Chao PC, Lai YY, Lin LY, Chou MY, Chou MC, Wei JC and Yang CC: In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standardised solution and its major constituent, salidroside. Phytother Res. 25:1604–1611. 2011.PubMed/NCBI

12 

Lu L, Yuan J and Zhang S: Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats. Age (Dordr). 35:637–646. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Guan S, He J, Guo W, Wei J, Lu J and Deng X: Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice. Immunopharmacol Immunotoxicol. 33:738–743. 2011.

14 

Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G and Glass CK: 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci USA. 97:4844–4849. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Okada M, Yan SF and Pinsky DJ: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. FASEB J. 16:1861–1868. 2002. View Article : Google Scholar

16 

Ma X, Chang W, Zhang C, Zhou X and Yu F: Staphylococcal Panton-Valentine leukocidin induces pro-inflammatory cytokine production and nuclear factor-kappa B activation in neutrophils. PLoS One. 7:e349702012. View Article : Google Scholar : PubMed/NCBI

17 

Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastruzzo C, Catalano P, Sortino M, Crimi N, Caputi AP, Thiemermann C and Vancheri C: Effect of rosiglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on bleomycin-induced lung injury. Eur Respir J. 25:225–234. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Lipke AB, Matute-Bello G, Herrero R, Kurahashi K, Wong VA, Mongovin SM and Martin TR: Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. J Immunol. 184:3801–3813. 2010. View Article : Google Scholar

19 

Repine JE and Elkins ND: Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats. Prev Med. 54(Suppl): S79–S82. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, Luo X, Yang JH, Carter D and Rabinovici R: Characterization of a murine model of endotoxin-induced acute lung injury. Shock. 17:300–303. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Idriss HT and Naismith JH: TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 50:184–195. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Perl M, Lomas-Neira J, Chung CS and Ayala A: Epithelial cell apoptosis and neutrophil recruitment in acute lung injury - a unifying hypothesis? What we have learned from small interfering RNAs. Mol Med. 14:465–475. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A and Spragg R: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 149:818–824. 1994. View Article : Google Scholar

24 

Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME and Suratt BT: Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol. 178:8148–8157. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Ryu SL, Shim JW, Kim DS, Jung HL, Park MS, Park SH, Lee J, Lee WY and Shim JY: Expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue. Korean J Pediatr. 56:151–158. 2013.

26 

Hunter RL, Choi DY, Ross SA and Bing GY: Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neurosci Lett. 432:198–201. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Ricote M, Li AC, Willson TM, Kelly CJ and Glass CK: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 391:79–82. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Standage SW, Caldwell CC, Zingarelli B and Wong HR: Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164–169. 2012.

29 

Christman JW, Sadikot RT and Blackwell TS: The role of nuclear factor-kappa β in pulmonary diseases. Chest. 117:1482–1487. 2000.

30 

Delerive P, Gervois P, Fruchart JC and Staels B: Induction of Iκβalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem. 275:36703–36707. 2000.

31 

Hahn I, Klaus A, Janze AK, Steinwede K, Ding N, Bohling J, Brumshagen C, Serrano H, Gauthier F, Paton JC, Welte T and Maus UA: Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun. 79:4893–4901. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O’Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA and Moldawer LL: Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest. 91:1787–1795. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Zhou G, Kamenos G, Pendem S, Wilson JX and Wu F: Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis. Am J Physiol Regul Integr Comp Physiol. 302:R409–R416. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H and Shushakova N: The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care. 15:R2612011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu MW, Su MX, Qin LF, Liu X, Tian ML, Zhang W and Wang Y: Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats. Exp Ther Med 7: 1446-1456, 2014.
APA
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., & Wang, Y. (2014). Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats. Experimental and Therapeutic Medicine, 7, 1446-1456. https://doi.org/10.3892/etm.2014.1629
MLA
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., Wang, Y."Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats". Experimental and Therapeutic Medicine 7.6 (2014): 1446-1456.
Chicago
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., Wang, Y."Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1446-1456. https://doi.org/10.3892/etm.2014.1629
Copy and paste a formatted citation
x
Spandidos Publications style
Liu MW, Su MX, Qin LF, Liu X, Tian ML, Zhang W and Wang Y: Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats. Exp Ther Med 7: 1446-1456, 2014.
APA
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., & Wang, Y. (2014). Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats. Experimental and Therapeutic Medicine, 7, 1446-1456. https://doi.org/10.3892/etm.2014.1629
MLA
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., Wang, Y."Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats". Experimental and Therapeutic Medicine 7.6 (2014): 1446-1456.
Chicago
Liu, M., Su, M., Qin, L., Liu, X., Tian, M., Zhang, W., Wang, Y."Effect of salidroside on lung injury by upregulating peroxisome proliferator‑activated receptor γ expression in septic rats". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1446-1456. https://doi.org/10.3892/etm.2014.1629
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