Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis

  • Authors:
    • Jun Li
    • Ting Zhou
    • Futao Zhao
  • View Affiliations

  • Published online on: March 27, 2014     https://doi.org/10.3892/etm.2014.1636
  • Pages: 1639-1642
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the inhibitory effect of sodium houttuyfonate (SH) on synovial cell proliferation in vitro. Primary cells were obtained from the synovial tissue of a patient with rheumatoid arthritis (RA). The cells were divided into five treatment groups as follows: the control group (group 1), 25 µg/ml SH‑treated group (group 2), 50 µg/ml SH‑treated group (group 3), 100 µg/ml SH‑treated group (group 4) and the 200 µg/ml SH‑treated group (group 5). Following seven days of treatment, the proliferation rate of the synovial cells was then detected using an MTT assay. The expression level of proliferative synovial cells markedly decreased in the SH‑treated groups in a dose-dependent manner compared with the control group. In conclusion, the present study demonstrated that SH was able to inhibit the proliferation of synovial cells obtained from a patient with RA. These results provide a potential theoretical basis for the development of a safe and effective treatment against RA in the future.
View Figures
View References

Related Articles

Journal Cover

June-2014
Volume 7 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhou T and Zhao F: Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis. Exp Ther Med 7: 1639-1642, 2014
APA
Li, J., Zhou, T., & Zhao, F. (2014). Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis. Experimental and Therapeutic Medicine, 7, 1639-1642. https://doi.org/10.3892/etm.2014.1636
MLA
Li, J., Zhou, T., Zhao, F."Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis". Experimental and Therapeutic Medicine 7.6 (2014): 1639-1642.
Chicago
Li, J., Zhou, T., Zhao, F."Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1639-1642. https://doi.org/10.3892/etm.2014.1636