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Article

Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus

  • Authors:
    • Yong Su
    • Ya-Li Su
    • Li-Fang Lv
    • Li-Min Wang
    • Quan-Zhong Li
    • Zhi-Gang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, P.R. China
  • Pages: 1752-1756
    |
    Published online on: March 27, 2014
       https://doi.org/10.3892/etm.2014.1637
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Abstract

The aim of this study was to assess the efficacy of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Type II diabetic patients exhibiting poor glycemic control following α-glucosidase inhibitor treatment for at least two months were selected and randomly distributed into vildagliptin and placebo groups. The body weight, fasting blood glucose (FBG), postprandial glucose (PPG), glycated hemoglobin (HBA1c) and blood lipid levels and hepatorenal functions of the patients were determined before and 12 weeks after the trial. Following the trial, the FBG, PPG, HbA1c, cholesterol (CHOL) and triglyceride (TG) levels in the vildagliptin group were significantly decreased compared with the pretreatment levels (P<0.05), whereas only the PPG level in the placebo group decreased (P<0.05). The FBG, PPG and HbA1c levels in the vildagliptin group were markedly lower than those in the placebo group 12 weeks after the trial. A comparison of the body weights and hepatorenal functions before and after the trial or between groups did not show statistically significant differences. The combination therapy of vildagliptin plus an α-glucosidase inhibitor effectively reduced the FBG, PPG and HbA1c levels in patients without inducing weight gain or hepatorenal dysfunction. However, the therapy may have caused a reduction in the blood lipid levels.
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1 

Samraj GP: Vildagliptin for the treatment of diabetes. Therapy. 8:703–719. 2011. View Article : Google Scholar

2 

Croxtall JD and Keam SJ: Vildagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs. 68:2387–2409. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Masuda K, Aoki K and Terauchi Y: Effects of miglitol taken just before or after breakfast on plasma glucose, serum insulin, glucagon and incretin levels after lunch in men with normal glucose tolerance, impaired fasting glucose or impaired glucose tolerance. J Diabet Invest. 2:435–440. 2011. View Article : Google Scholar

4 

Aoki K, Kamiyama H, Yoshimura K, Shibuya M, Masuda K and Terauchi Y: Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. Acta Diabetol. 49:225–230. 2012. View Article : Google Scholar

5 

Narita T, Katsuura Y, Sato T, et al: Miglitol induces prolonged and enhanced glucagon-like peptide-1 and reduced gastric inhibitory polypeptide response after ingestion of a mixed meal in Japanese Type 2 diabetic patients. Diabet Med. 26:187–188. 2009. View Article : Google Scholar

6 

Arakawa M, Ebato C, Mita T, et al: Miglitol suppresses the postprandial increases in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. Metabolism. 57:1299–1306. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Aoki K, Miyazaki T, Nagakura J, Orime K, Togashi Y and Terauchi Y: Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucose dependent insulinotropic polypeptide levels in healthy men. Endocr J. 57:673–677. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pi-Sunyer FX, Schweizer A, Mills D and Dejager S: Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract. 76:132–138. 2007.PubMed/NCBI

9 

Tahrani AA, Piya MK and Barnett AH: Drug evaluation: vildagliptin-metformin single-tablet combination. Adv Ther. 26:138–154. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Ahrén B: Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - diabetes control and potential adverse events. Best Pract Res Clin Endocrinol Metab. 23:487–498. 2009.PubMed/NCBI

11 

Bosi E, Dotta F, Jia Y and Goodman M: Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus. Diabetes Obes Metab. 11:506–515. 2009. View Article : Google Scholar

12 

Devendra D, Gohel B, Bravis V, et al: Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan. Int J Clin Pract. 63:1446–1450. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Matthews DR, Dejager S, Ahren B, et al: Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with gimepiride, with no weight gain: results from a 2-year study. Diabetes Obes Metab. 12:780–789. 2010.PubMed/NCBI

14 

Iwamoto Y, Kashiwagi A, Yamada N, et al: Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study. Diabetes Obes Metab. 12:700–708. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Schweizer A, Dejager S, Foley JE, Shao Q and Kothny W: Clinical experience with vildagliptin in the management of type 2 diabetes in a patient population ≥ 75 years: a pooled analysis from a data base of clinical trials. Diabetes Obes Metab. 13:55–64. 2011.PubMed/NCBI

16 

Ligueros-Saylan M, Foley JE, Schweizer A, Couturier A and Kothny W: An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials. Diabetes Obes Metab. 12:495–509. 2010. View Article : Google Scholar

17 

Richard KR, Shelburne JS and Kirk JK: Tolerability of dipeptidyl peptidase-4 inhibitors: a review. Clin Ther. 33:1609–1629. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kahn SE, Haffner SM, Heise MA, et al: Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 355:2427–2443. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Dormandy JA, Charbonnel B, Eckland DJ, et al: Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 366:1279–1289. 2005. View Article : Google Scholar

20 

Ilag LL, Kerr L, Malone JK and Tan MH: Prandial premixed insulin analogue regimens versus basal insulin analogue regimens in the management of type 2 diabetes: an evidence-based comparison. Clin Ther. 29:1254–1270. 2007. View Article : Google Scholar

21 

Neumiller JJ: Differential chemistry (structure), mechanisnm faction, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitor. J Am Pharm Assoc (2003). 49(Suppl 1): S16–S29. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su Y, Su Y, Lv L, Wang L, Li Q and Zhao Z: Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Exp Ther Med 7: 1752-1756, 2014.
APA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., & Zhao, Z. (2014). Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Experimental and Therapeutic Medicine, 7, 1752-1756. https://doi.org/10.3892/etm.2014.1637
MLA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7.6 (2014): 1752-1756.
Chicago
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1752-1756. https://doi.org/10.3892/etm.2014.1637
Copy and paste a formatted citation
x
Spandidos Publications style
Su Y, Su Y, Lv L, Wang L, Li Q and Zhao Z: Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Exp Ther Med 7: 1752-1756, 2014.
APA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., & Zhao, Z. (2014). Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus. Experimental and Therapeutic Medicine, 7, 1752-1756. https://doi.org/10.3892/etm.2014.1637
MLA
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7.6 (2014): 1752-1756.
Chicago
Su, Y., Su, Y., Lv, L., Wang, L., Li, Q., Zhao, Z."Randomized controlled clinical trial of a combination therapy of vildagliptin plus an α-glucosidase inhibitor for patients with type II diabetes mellitus". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1752-1756. https://doi.org/10.3892/etm.2014.1637
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