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Article

Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers

  • Authors:
    • Guobao Huang
    • Tangqing Sun
    • Lei Zhang
    • Qiuhe Wu
    • Keyan Zhang
    • Qingfen Tian
    • Ran Huo
  • View Affiliations / Copyright

    Affiliations: Department of Burn and Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Burn and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
  • Pages: 1772-1776
    |
    Published online on: March 31, 2014
       https://doi.org/10.3892/etm.2014.1652
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Abstract

The aim of the present study was to evaluate the clinical therapeutic effect of the combined application of alginate and recombinant human granulocyte‑macrophage colony‑stimulating factor (rhGM‑CSF) on the healing of refractory chronic skin ulcers. A single center, three arm, randomized study was performed at Jinan Central Hospital (Jinan, Shandong, China). A total of 60 patients with refractory chronic skin ulcers, which persisted for >1 month, were enrolled and randomly assigned into one of the following three groups: alginate dressing/rhGM‑CSF group (group A), rhGM‑CSF only group (group B) and conventional (vaseline dressing) group (group C). The wound area rate was measured, granulation and color were observed and pain was evaluated. The data were summarized and statistical analysis was performed. The results demonstrated that group A exhibited a significantly faster wound healing rate and lower pain score compared with the other groups (P<0.01). In conclusion, the combined application of alginate dressing and rhGM‑CSF for the treatment of refractory chronic skin ulcers demonstrated significant advantages. It promoted the growth of granulation tissue, accelerated re‑epithelialization and also effectively reduced wound pain, and thus improved the quality of life for the patient. This suggests that the combined application of alginate and rhGM‑CSF may be an effective therapeutic strategy for the clinical treatment of refractory chronic skin ulcers.
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Copy and paste a formatted citation
Spandidos Publications style
Huang G, Sun T, Zhang L, Wu Q, Zhang K, Tian Q and Huo R: Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers. Exp Ther Med 7: 1772-1776, 2014.
APA
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., & Huo, R. (2014). Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers. Experimental and Therapeutic Medicine, 7, 1772-1776. https://doi.org/10.3892/etm.2014.1652
MLA
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., Huo, R."Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers". Experimental and Therapeutic Medicine 7.6 (2014): 1772-1776.
Chicago
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., Huo, R."Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1772-1776. https://doi.org/10.3892/etm.2014.1652
Copy and paste a formatted citation
x
Spandidos Publications style
Huang G, Sun T, Zhang L, Wu Q, Zhang K, Tian Q and Huo R: Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers. Exp Ther Med 7: 1772-1776, 2014.
APA
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., & Huo, R. (2014). Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers. Experimental and Therapeutic Medicine, 7, 1772-1776. https://doi.org/10.3892/etm.2014.1652
MLA
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., Huo, R."Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers". Experimental and Therapeutic Medicine 7.6 (2014): 1772-1776.
Chicago
Huang, G., Sun, T., Zhang, L., Wu, Q., Zhang, K., Tian, Q., Huo, R."Combined application of alginate dressing and human granulocyte‑macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1772-1776. https://doi.org/10.3892/etm.2014.1652
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