Urantide improves atherosclerosis by controlling C‑reactive protein, monocyte chemotactic protein‑1 and transforming growth factor-β expression in rats

Zhao,Juan; Xie,Li-De; Song,Cheng-Jun; Mao,Xiao-Xia; Yu,Hai-Rong; Yu,Quan‑Xin; Ren,Li-Qun; Shi,Yan; Xie,Ya‑Qin; Li,Ying; Liu,Sha-Sha; Yang,Xiao‑Hong

doi:10.3892/etm.2014.1654

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Article

Urantide improves atherosclerosis by controlling C‑reactive protein, monocyte chemotactic protein‑1 and transforming growth factor-β expression in rats

Authors:
- Juan Zhao
- Li-De Xie
- Cheng-Jun Song
- Xiao-Xia Mao
- Hai-Rong Yu
- Quan‑Xin Yu
- Li-Qun Ren
- Yan Shi
- Ya‑Qin Xie
- Ying Li
- Sha-Sha Liu
- Xiao‑Hong Yang
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Affiliations: School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China
Pages: 1647-1652
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Published online on: March 31, 2014

https://doi.org/10.3892/etm.2014.1654
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Abstract

The aim of the present study was to investigate the effects of urantide on the expression status of C‑reactive protein (CRP) and the inflammatory cytokines monocyte chemotactic protein (MCP)-1 and transforming growth factor (TGF)-β in the aortas of rats with atherosclerosis (AS), and to identify its underlying mechanisms. The effects of urantide in a rat model of AS and in cultured rat vascular smooth muscle cells (VSMCs) were analyzed via hematoxylin and eosin staining, immunohistochemical staining and ELISA. The results in vivo demonstrated that urantide downregulated the expression of inflammatory mediators CRP and MCP‑1 and upregulated the expression of TGF‑β. The results in vitro indicated that urantide inhibited the proliferation of VSMCs. In addition, urantide reduced the expression of CRP and downregulated the secretion of TGF‑β in the culture supernatant. In conclusion, urantide ameliorated the arterial inflammatory damage that was observed in the AS rat model at the cell and tissue levels by controlling the expression of CRP and the inflammatory cytokines MCP‑1 and TGF‑β. Therefore, urantide may be a potential agent for the complementary treatment of AS.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Urantide improves atherosclerosis by controlling C‑reactive protein, monocyte chemotactic protein‑1 and transforming growth factor-β expression in rats

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