Evaluating the diagnostic value of vWF:Ag, D-D and FDP in patients with acute cerebral infarction using ROC curves

Shi,Dongmin; Xia,Ting; Feng,Hongxuan; Cheng,Qingzhang

doi:10.3892/etm.2014.1665

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Article

Evaluating the diagnostic value of vWF:Ag, D-D and FDP in patients with acute cerebral infarction using ROC curves

Authors:
- Dongmin Shi
- Ting Xia
- Hongxuan Feng
- Qingzhang Cheng
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Affiliations: Department of Laboratory Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, P.R. China, First Cadres Sanatorium, Second Military Medical University, Shanghai 200433, P.R. China, Department of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, P.R. China, Department of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, P.R. China
Pages: 1573-1577
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Published online on: April 3, 2014

https://doi.org/10.3892/etm.2014.1665
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Abstract

Cerebral infarction is usually associated with arteriosclerosis, vascular endothelial cell injury and blood flow through the vascular system. The diagnostic value of markers, including von Willebrand factor antigen (vWF:Ag), D‑dimer (D‑D) and fibrinogen/fibrin degradation product (FDP), have not been studied in patients with acute cerebral infarction. Thus, the aim of the present study was to use receiver operating characteristic (ROC) curves to evaluate the diagnostic significance of vWF:Ag, D‑D and FDP in 94 cases of acute cerebral infarction. The results revealed that vWF:Ag and D‑D concentrations were significantly higher in acute cerebral infarction patients as compared with the normal controls (P<0.01), whereas no statistically significant difference in FDP was observed between the groups (P>0.01). Plasma vWF:Ag and D‑D concentrations significantly correlated with the National Institute of Health Stroke Scale (NIHSS) scores (r=0.625 and 0.582, respectively; P<0.01). In addition, the vWF:Ag concentration significantly correlated with the D‑D concentration (r=0.320; P<0.01), whereas FDP concentration did not correlate with D‑D or vWF:Ag concentrations or the NIHSS scores (r=0.172, 0.188 and 0.065, respectively; P>0.05). The area under the ROC curve using vWF:Ag as a diagnostic marker in patients with acute cerebral infarction was 0.900, while for D‑D the area was 0.795 and for FDP the area was 0.465. Logistic regression analysis revealed that the odds ratios of vWF:Ag and D‑D were 16.727 and 2.324, respectively, which were statistically significant (P<0.001 and 0.023, respectively). These results indicated that using vWF:Ag as a diagnostic marker is likely to significantly improve the sensitivity of diagnosing patients with acute cerebral infarction. The diagnostic value of vWF:Ag concentration was significantly higher compared with D‑D and FDP levels.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

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Oncology Reports

Experimental and Therapeutic Medicine

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Molecular and Clinical Oncology

World Academy of Sciences Journal

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International Journal of Epigenetics

Medicine International

Evaluating the diagnostic value of vWF:Ag, D-D and FDP in patients with acute cerebral infarction using ROC curves

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