Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury

Rockswold SB, Rockswold GL, Zaun DA and Liu J: A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. J Neurosurg. 118:1317–1328. 2013. View Article : Google Scholar

Lee KS, Shim JJ, Yoon SM and Bae HG: Prognostic value of the C-reactive protein levels in the head injury. J Kor Eurotraumatol Soc. 1:57–60. 2005.

da Gullo JS, Bertotti MM, Silva CC, et al: Hospital mortality of patients with severe traumatic brain injury is associated with serum PTX3 levels. Neurocrit Care. 14:194–199. 2011.PubMed/NCBI

Cao LJ, Wang J, Hao PP, Sun CL and Chen YG: Effects of ulinastatin, a urinary trypsin inhibitor, on synaptic plasticity and spatial memory in a rat model of cerebral ischemia/reperfusion injury. Chin J Physiol. 54:435–442. 2011.PubMed/NCBI

Wang X, Xue Q, Yan F, et al: Ulinastatin as a neuroprotective and anti-inflammatory agent in infant piglets model undergoing surgery on hypothermic low-flow cardiopulmonary bypass. Paediatr Anaesth. 23:209–216. 2013. View Article : Google Scholar : PubMed/NCBI

Stewart TC, Alharfi IM and Fraser DD: The role of serious concomitant injuries in the treatment and outcome of pediatric severe traumatic brain injury. J Trauma Acute Care Surg. 75:836–842. 2013. View Article : Google Scholar : PubMed/NCBI

Schmidt AT, Hanten G, Li X, et al: Emotional prosody and diffusion tensor imaging in children after traumatic brain injury. Brain Inj. 27:1528–1535. 2013. View Article : Google Scholar : PubMed/NCBI

Lord LD, Expert P, Huckins JF and Turkheimer FE: Cerebral energy metabolism and the brain’s functional network architecture: an integrative review. J Cereb Blood Flow Metab. 33:1347–1354. 2013.

McCarthy MC, Moncrief H, Sands JM, et al: Neurologic outcomes with cerebral oxygen monitoring in traumatic brain injury. Surgery. 146:585–591. 2009. View Article : Google Scholar : PubMed/NCBI

Mayer CL, Huber BR and Peskind E: Traumatic brain injury, neuroinflammation, and post-traumatic headaches. Headache. 53:1523–1530. 2013.PubMed/NCBI

Wang XH, Wei RL, Fan H and Hu JH: The protective effects of edaravone combined with ulinastatin on the treatment of brain iniury in rats with severe acute pancreatitis. Zhonghua Gan Dan Wai Ke Za Zhi. 19:544–549. 2013.(In Chinese).

Bouzat P, Millet A, Boue Y, et al: Changes in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin. Crit Care Med. 41:1316–1324. 2013. View Article : Google Scholar : PubMed/NCBI

Kamenskaia OV, Loginova IIu, Karpenko AA, Karas’kov AM and Kuzhuget RA: Oxygen supply to the brain in chronic disturbances of cerebral circulation in patients with pathology of brachiocephalic arteries. Kardiologiia. 53:49–53. 2013.(In Russian).

Faraco G, Moraga A, Moore J, et al: Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation. Hypertension. 62:759–766. 2013. View Article : Google Scholar : PubMed/NCBI

Tu Y, Diao YF, Yang XP, Sun HT and Zhang S: Effect of ulinastatin in traumatic brain injury with multiple injuries. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 24:677–679. 2012.(In Chinese).

Xu CE, Zou CW, Zhang MY and Guo L: Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth. 27:479–484. 2013. View Article : Google Scholar

Cao BP, Zhang L, Su N, Wang K, Bian H, Fei Z and Li B: Protective effects of ulinastatin on mice with traumatic brain injury. Zhonghua Shen Jing Wai Ke Ji Bing Yan Jiu Za Zhi. 12:244–246. 2013.(In Chinese).