Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2014 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats

  • Authors:
    • You‑Xing Zhou
    • Yong Ni
    • Yi‑Bing Liu
    • Xiaohong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, P.R. China, Department of Hepatobiliary Surgery, Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, P.R. China, Department of Geriatric Psychiatry, Wuxi Mental Health Center, Wuxi, Jiangsu 214151, P.R. China
  • Pages: 15-20
    |
    Published online on: April 25, 2014
       https://doi.org/10.3892/etm.2014.1697
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage‑associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs from injury, and histones have been recently identified as DAMP molecules. The aim of the present study was to investigate the protective effect of histone preconditioning against OJ‑induced liver injury in rats and the involvement of Toll‑like receptors. Rats were administered histone proteins (200 µg/kg; 1 ml) or physiological saline (1 ml) intraperitoneally 24 h prior to being subjected to bile duct ligation (BDL). The serum levels of liver enzymes and bilirubin, as well as the histopathology were analyzed. The mRNA expression of interleukin‑6 (IL‑6) in the liver tissue was analyzed using quantitative polymerase chain reaction. BDL in the control group caused severe OJ‑induced liver injury, as indicated by the significantly elevated levels of liver enzymes and mRNA levels of IL‑6, and confirmed by histopathological alterations. However, histone preconditioning significantly ameliorated the OJ‑induced liver injury caused by BDL, as shown by an improvement in the levels of liver enzymes, a suppression of IL‑6 production, as well as histopathological alterations. Therefore, these results suggested that histone preconditioning is able to protect against OJ‑induced liver injury in rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Tsuyuguchi T, Takada T, Miyazaki M, et al: Stenting and interventional radiology for obstructive jaundice in patients with unresectable biliary tract carcinomas. J Hepatobiliary Pancreat Surg. 15:69–73. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Gujral JS, Farhood A, Bajt ML and Jaeschke H: Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology. 38:355–363. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Koeppel TA, Trauner M, Baas JC, et al: Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology. 26:1085–1091. 1997.PubMed/NCBI

4 

Huang YH, Wang PW, Tiao MM, et al: Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. J Surg Res. 170:e47–e55. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Klune JR, Billiar TR and Tsung A: HMGB1 preconditioning: therapeutic application for a danger signal? J Leukoc Biol. 83:558–563. 2008. View Article : Google Scholar : PubMed/NCBI

6 

He W, Fong Y, Marano MA, Gershenwald JE, Yurt RW, Moldawer LL and Lowry SF: Tolerance to endotoxin prevents mortality in infected thermal injury: association with attenuated cytokine responses. J Infect Dis. 165:859–864. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Colletti LM, Remick DG and Campbell DA Jr: LPS pretreatment protects from hepatic ischemia/reperfusion. J Surg Res. 57:337–343. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Ackerman M, Reuter M, Flohé S, Bahrami S, Redl H and Schade FU: Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock. J Endotoxin Res. 7:105–112. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Mao SM, Zhang BM, Guan XD, Li J, Jia YB and Pan HY: The effect of hyperthermia preconditioning on the liver function of obstructive jaundice rats. J Pract Med. 23:3037–3838. 2007.

10 

Mao SM, Zhang BM, Guan XD, Li J, Pan HY and Jia YB: The effect of hyperthermia pretreatment on the subgroups of T lymphocytes in obstructive jaundiced rats. Shijie Huaren Xiaohua Zazhi. 15:3035–3037. 2007.

11 

Güllüoğlu BM, Bekraki A, Cerikçioğlu N, Söyletir G and Aktan AO: Immunologic influences of hyperthermia in a rat model of obstructive jaundice. Dig Dis Sci. 46:2378–2384. 2001.PubMed/NCBI

12 

Hu X, Jiang H, Cui B, et al: Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury. Int J Cardiol. 145:111–112. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ha T, Hua F, Liu X, et al: Lipopolysccharide-induced myocardial protection against ischeamia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovasc Res. 78:546–553. 2008. View Article : Google Scholar

14 

Zacharowski K, Frank S and Otto M: Lipoteichoic acid induces delayed protection in the rat heart, a comparison with endotoxin. Arterioscler Thromb Vasc Biol. 20:1521–1528. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Aneja R, Odoms K, Dunsmore K, Shanley TP and Wong HR: Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells. J Immunol. 177:7184–7192. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Izuishi K, Tsung A, Jeyabalan G, et al: Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol. 176:7154–7158. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Huang H, Evankovich J, Yan W, et al: Endogenous histones function as alarmins in sterile inflammatory liver injury through toll-like receptor 9. Hepatology. 54:999–1008. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Raetsch C, Jia JD, Boigk G, Bauer M, Hahn EG, Riecken EO and Schuppan D: Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut. 50:241–247. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Ishak K, Babtista A, Bianchi L, Callea F, De Groote J, Gudot F, Denk H, Desmet V, Korb G, MacSween RN, Phillips MJ, Portmann BG, Poulsen H, Scheuer PJ, Schmid M and Thaler H: Histological grading and staging of chronic hepatitis. J Hepatol. 22:696–699. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Hammel P, Couvelard A, O’Toole D, et al: Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 344:418–423. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Kimmings AN, van Deventer SJ, Obertop H, Rauws EA, Huibregtse K and Gouma DJ: Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage. Gut. 46:725–731. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Chuang JH, Chang NK, Huang CC, et al: Biliary intervention augments chemotactic reaction and aggravates cholestatic liver injury in rats. J Surg Res. 120:210–218. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Martignoni ME, Wagner M, Krähenbühl L, et al: Effect of preoperative biliary drainage on surgical outcome after pancreaticoduodenectomy. Am J Surg. 181:52–59. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Sano T, Izuishi K, Hossain MA, Kakinoki K, Okano K, Masaki T and Suzuki Y: Protective effect of lipopolysaccharide preconditioning in hepatic ischaemia reperfusion injury. HPB (Oxford). 12:538–545. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Bemelmans MH, Gouma DJ, Greve JW and Buurman WA: Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice. Hepatology. 15:1132–1136. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Van Bossuyt H, Desmaretz C, Gaeta GB and Wisse E: The role of bile acids in the development of endotoxemia during obstructive jaundice in the rat. J Hepatol. 10:274–279. 1990.PubMed/NCBI

27 

Xu J, Zhang X, Monestier M, Esmon NL and Esmon CT: Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol. 187:2626–2631. 2011. View Article : Google Scholar : PubMed/NCBI

28 

van Holde KE: Histone modifications. Chromatin. 4. 1st edition. Springer; New York, NY: pp. 111–148. 1988

29 

Strahl BD and Allis CD: The language of covalent histone modifications. Nature. 403:41–45. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Opie LH and Sack MN: Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J Mol Cell Cardiol. 34:1077–1089. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Chen W, Glasgow W, Murphy E and Steenbergen C: Lipooxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart. Am J Physiol. 276:H2094–H2101. 1999.PubMed/NCBI

32 

Schulz R, Rose J and Heusch G: Involvement of activation of AT dependent potassium channels in ischemic preconditioning in swine. Am J Physiol. 267:H1341–H1352. 1994.PubMed/NCBI

33 

Marber MS, Latchman DS, Walker JM and Yellon DM: Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation. 88:1264–1272. 1993. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou YX, Ni Y, Liu YB and Liu X: Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Exp Ther Med 8: 15-20, 2014.
APA
Zhou, Y., Ni, Y., Liu, Y., & Liu, X. (2014). Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Experimental and Therapeutic Medicine, 8, 15-20. https://doi.org/10.3892/etm.2014.1697
MLA
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8.1 (2014): 15-20.
Chicago
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8, no. 1 (2014): 15-20. https://doi.org/10.3892/etm.2014.1697
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou YX, Ni Y, Liu YB and Liu X: Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Exp Ther Med 8: 15-20, 2014.
APA
Zhou, Y., Ni, Y., Liu, Y., & Liu, X. (2014). Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Experimental and Therapeutic Medicine, 8, 15-20. https://doi.org/10.3892/etm.2014.1697
MLA
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8.1 (2014): 15-20.
Chicago
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8, no. 1 (2014): 15-20. https://doi.org/10.3892/etm.2014.1697
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team