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Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats

  • Authors:
    • You‑Xing Zhou
    • Yong Ni
    • Yi‑Bing Liu
    • Xiaohong Liu
  • View Affiliations

  • Published online on: April 25, 2014     https://doi.org/10.3892/etm.2014.1697
  • Pages: 15-20
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Abstract

A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage‑associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs from injury, and histones have been recently identified as DAMP molecules. The aim of the present study was to investigate the protective effect of histone preconditioning against OJ‑induced liver injury in rats and the involvement of Toll‑like receptors. Rats were administered histone proteins (200 µg/kg; 1 ml) or physiological saline (1 ml) intraperitoneally 24 h prior to being subjected to bile duct ligation (BDL). The serum levels of liver enzymes and bilirubin, as well as the histopathology were analyzed. The mRNA expression of interleukin‑6 (IL‑6) in the liver tissue was analyzed using quantitative polymerase chain reaction. BDL in the control group caused severe OJ‑induced liver injury, as indicated by the significantly elevated levels of liver enzymes and mRNA levels of IL‑6, and confirmed by histopathological alterations. However, histone preconditioning significantly ameliorated the OJ‑induced liver injury caused by BDL, as shown by an improvement in the levels of liver enzymes, a suppression of IL‑6 production, as well as histopathological alterations. Therefore, these results suggested that histone preconditioning is able to protect against OJ‑induced liver injury in rats.
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July-2014
Volume 8 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou YX, Ni Y, Liu YB and Liu X: Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Exp Ther Med 8: 15-20, 2014.
APA
Zhou, Y., Ni, Y., Liu, Y., & Liu, X. (2014). Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats. Experimental and Therapeutic Medicine, 8, 15-20. https://doi.org/10.3892/etm.2014.1697
MLA
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8.1 (2014): 15-20.
Chicago
Zhou, Y., Ni, Y., Liu, Y., Liu, X."Histone preconditioning protects against obstructive jaundice‑induced liver injury in rats". Experimental and Therapeutic Medicine 8, no. 1 (2014): 15-20. https://doi.org/10.3892/etm.2014.1697