Association between IL‑21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population

  • Authors:
    • Hua Zeng
    • Haiyan Yan
    • Zhixian Zhang
    • Weizhen Fang
    • Rui Ding
    • Lisi Huang
    • Mei Chen
    • Jin Zhang
  • View Affiliations

  • Published online on: May 12, 2014     https://doi.org/10.3892/etm.2014.1707
  • Pages: 213-218
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Abstract

Interleukin‑21 (IL‑21) is a pleiotropic cytokine linking innate and adaptive immune responses, which has been reported to play a key role in multiple autoimmune diseases. The aim of the present case‑control study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of rs907715 within the IL‑21 gene and Graves' disease (GD) in a Southern Chinese population. A total of 211 patients with GD and 212 control subjects were recruited for the study. IL‑21 gene rs907715 polymorphisms were detected by direct DNA sequencing. The results indicated that the frequencies of the GG genotype and the G allele in GD patients were significantly increased when compared with the frequencies in the controls (P=6.7x10‑3 and P=2.0x10‑5, respectively). In addition, the frequency of the AA genotype was much lower in the patient group when compared with the control group (16.6 vs. 34.0%; P=4.0x10‑5). Furthermore, the G allele of rs907715 was associated with relapse in GD patients. These observations indicated that polymorphisms of IL‑21/rs907715 may affect the susceptibility to GD in a Southern Chinese population. The G allele was significantly associated with an increased risk of GD development, whereas the A allele may lower the susceptibility to GD.
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July-2014
Volume 8 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zeng H, Yan H, Zhang Z, Fang W, Ding R, Huang L, Chen M and Zhang J: Association between IL‑21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population. Exp Ther Med 8: 213-218, 2014
APA
Zeng, H., Yan, H., Zhang, Z., Fang, W., Ding, R., Huang, L. ... Zhang, J. (2014). Association between IL‑21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population. Experimental and Therapeutic Medicine, 8, 213-218. https://doi.org/10.3892/etm.2014.1707
MLA
Zeng, H., Yan, H., Zhang, Z., Fang, W., Ding, R., Huang, L., Chen, M., Zhang, J."Association between IL‑21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population". Experimental and Therapeutic Medicine 8.1 (2014): 213-218.
Chicago
Zeng, H., Yan, H., Zhang, Z., Fang, W., Ding, R., Huang, L., Chen, M., Zhang, J."Association between IL‑21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population". Experimental and Therapeutic Medicine 8, no. 1 (2014): 213-218. https://doi.org/10.3892/etm.2014.1707