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Article

Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion

  • Authors:
    • Xiaorong Hu
    • Kai Zhang
    • Changwu Xu
    • Zhiqaing Chen
    • Hong Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Cardiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei 435000, P.R. China
  • Pages: 229-232
    |
    Published online on: May 20, 2014
       https://doi.org/10.3892/etm.2014.1726
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Abstract

High mobility group box 1 protein (HMGB1) has an important role in myocardial ischemia/reperfusion (I/R) injury. Sodium butyrate, an inhibitor of histone deacetylase, has been shown to inhibit HMGB1 expression. In the present study, the effect of sodium butyrate on myocardial I/R injury in rats was investigated. Anesthetized male rats were intraperitoneally administered sodium butyrate (100 or 300 mg/kg) 30 min prior to the induction of ischemia. The rats were then subjected to ischemia for 30 min followed by reperfusion for 4 h. Infarct size, lactate dehydrogenase (LDH), creatine kinase (CK) and superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels were then measured. The expression of HMGB1 was assessed using western blot analysis. The results demonstrated that pretreatment with sodium butyrate (300 mg/kg) significantly reduced the infarct size, as well as the levels of LDH and CK (P<0.05). In addition, sodium butyrate (300 mg/kg) was shown to significantly inhibit the I/R‑induced increase in the level of MDA and reduction in the level of SOD (P<0.05). Furthermore, treatment with sodium butyrate (300 mg/kg) was found to significantly inhibit the expression of TNF‑α, IL‑6 and HMGB1 induced by I/R injury (P<0.05). In conclusion, the results from the present study suggest that preconditioning with sodium butyrate may attenuate myocardial I/R injury by inhibition of the expression of inflammatory mediators during myocardial I/R.
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Copy and paste a formatted citation
Spandidos Publications style
Hu X, Zhang K, Xu C, Chen Z and Jiang H: Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion. Exp Ther Med 8: 229-232, 2014.
APA
Hu, X., Zhang, K., Xu, C., Chen, Z., & Jiang, H. (2014). Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion. Experimental and Therapeutic Medicine, 8, 229-232. https://doi.org/10.3892/etm.2014.1726
MLA
Hu, X., Zhang, K., Xu, C., Chen, Z., Jiang, H."Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion". Experimental and Therapeutic Medicine 8.1 (2014): 229-232.
Chicago
Hu, X., Zhang, K., Xu, C., Chen, Z., Jiang, H."Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion". Experimental and Therapeutic Medicine 8, no. 1 (2014): 229-232. https://doi.org/10.3892/etm.2014.1726
Copy and paste a formatted citation
x
Spandidos Publications style
Hu X, Zhang K, Xu C, Chen Z and Jiang H: Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion. Exp Ther Med 8: 229-232, 2014.
APA
Hu, X., Zhang, K., Xu, C., Chen, Z., & Jiang, H. (2014). Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion. Experimental and Therapeutic Medicine, 8, 229-232. https://doi.org/10.3892/etm.2014.1726
MLA
Hu, X., Zhang, K., Xu, C., Chen, Z., Jiang, H."Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion". Experimental and Therapeutic Medicine 8.1 (2014): 229-232.
Chicago
Hu, X., Zhang, K., Xu, C., Chen, Z., Jiang, H."Anti‑inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion". Experimental and Therapeutic Medicine 8, no. 1 (2014): 229-232. https://doi.org/10.3892/etm.2014.1726
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