PPM1D is a prognostic marker and therapeutic target in colorectal cancer

  • Authors:
    • Tian‑Shu Peng
    • Yong‑Heng He
    • Tian Nie
    • Xiang‑Dang Hu
    • Hai‑Yan Lu
    • Jian Yi
    • Yun‑Fei Shuai
    • Min Luo
  • View Affiliations

  • Published online on: June 6, 2014     https://doi.org/10.3892/etm.2014.1762
  • Pages: 430-434
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) has been associated with carcinogenesis. The present study investigated PPM1D expression as a potential biomarker in colorectal cancer (CRC). PPM1D expression was assessed using immunohistochemistry in 368 patients with CRC. The correlation between PPM1D expression, clinicopathological features and prognosis was analyzed. PPM1D small interfering (si)RNA‑induced PPM1D silencing was performed in CRC cell lines to assess the effect of PPM1D on tumor cell proliferation and invasion in vitro. A total of 68.48% (252/368) of the CRC samples displayed high PPM1D expression. By contrast, only 9.24% (34/368) of the matched non‑cancerous tissue samples exhibited high PPM1D expression. High PPM1D expression was correlated with node metastasis (P=0.0024), distant metastasis (P<0.001) and TNM stage (P=0.0016). Kaplan‑Meier survival analysis revealed that patients with low PPM1D expression had significantly longer survival than those with high PPM1D expression (P=0.012). Moreover, multivariate analyses demonstrated that high PPM1D expression was an independent prognostic factor for overall survival (hazard ratio = 0.24; 95% confidence interval, 0.13‑0.86; P=0.004). Furthermore, PPM1D gene silencing was found to significantly reduce the proliferation and invasion of CRC cells in vitro. These findings suggest a role for PPM1D as a prognostic marker and potential therapeutic target in CRC.
View Figures
View References

Related Articles

Journal Cover

August-2014
Volume 8 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Peng TS, He YH, Nie T, Hu XD, Lu HY, Yi J, Shuai YF and Luo M: PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Exp Ther Med 8: 430-434, 2014
APA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J. ... Luo, M. (2014). PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Experimental and Therapeutic Medicine, 8, 430-434. https://doi.org/10.3892/etm.2014.1762
MLA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8.2 (2014): 430-434.
Chicago
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8, no. 2 (2014): 430-434. https://doi.org/10.3892/etm.2014.1762