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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2014 Volume 8 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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International Journal of Epigenetics

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Article

PPM1D is a prognostic marker and therapeutic target in colorectal cancer

  • Authors:
    • Tian‑Shu Peng
    • Yong‑Heng He
    • Tian Nie
    • Xiang‑Dang Hu
    • Hai‑Yan Lu
    • Jian Yi
    • Yun‑Fei Shuai
    • Min Luo
  • View Affiliations / Copyright

    Affiliations: Department of Anorectal Disease, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, P.R. China, Department of Blood and Oncology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, P.R. China
  • Pages: 430-434
    |
    Published online on: June 6, 2014
       https://doi.org/10.3892/etm.2014.1762
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Abstract

Protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) has been associated with carcinogenesis. The present study investigated PPM1D expression as a potential biomarker in colorectal cancer (CRC). PPM1D expression was assessed using immunohistochemistry in 368 patients with CRC. The correlation between PPM1D expression, clinicopathological features and prognosis was analyzed. PPM1D small interfering (si)RNA‑induced PPM1D silencing was performed in CRC cell lines to assess the effect of PPM1D on tumor cell proliferation and invasion in vitro. A total of 68.48% (252/368) of the CRC samples displayed high PPM1D expression. By contrast, only 9.24% (34/368) of the matched non‑cancerous tissue samples exhibited high PPM1D expression. High PPM1D expression was correlated with node metastasis (P=0.0024), distant metastasis (P<0.001) and TNM stage (P=0.0016). Kaplan‑Meier survival analysis revealed that patients with low PPM1D expression had significantly longer survival than those with high PPM1D expression (P=0.012). Moreover, multivariate analyses demonstrated that high PPM1D expression was an independent prognostic factor for overall survival (hazard ratio = 0.24; 95% confidence interval, 0.13‑0.86; P=0.004). Furthermore, PPM1D gene silencing was found to significantly reduce the proliferation and invasion of CRC cells in vitro. These findings suggest a role for PPM1D as a prognostic marker and potential therapeutic target in CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Peng TS, He YH, Nie T, Hu XD, Lu HY, Yi J, Shuai YF and Luo M: PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Exp Ther Med 8: 430-434, 2014.
APA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J. ... Luo, M. (2014). PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Experimental and Therapeutic Medicine, 8, 430-434. https://doi.org/10.3892/etm.2014.1762
MLA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8.2 (2014): 430-434.
Chicago
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8, no. 2 (2014): 430-434. https://doi.org/10.3892/etm.2014.1762
Copy and paste a formatted citation
x
Spandidos Publications style
Peng TS, He YH, Nie T, Hu XD, Lu HY, Yi J, Shuai YF and Luo M: PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Exp Ther Med 8: 430-434, 2014.
APA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J. ... Luo, M. (2014). PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Experimental and Therapeutic Medicine, 8, 430-434. https://doi.org/10.3892/etm.2014.1762
MLA
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8.2 (2014): 430-434.
Chicago
Peng, T., He, Y., Nie, T., Hu, X., Lu, H., Yi, J., Shuai, Y., Luo, M."PPM1D is a prognostic marker and therapeutic target in colorectal cancer". Experimental and Therapeutic Medicine 8, no. 2 (2014): 430-434. https://doi.org/10.3892/etm.2014.1762
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