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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2014 Volume 8 Issue 2

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Article

Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats

  • Authors:
    • Fan Zhang
    • Zhao‑Qiong Zhu
    • De‑Xing Liu
    • Chao Zhang
    • Qi‑Hai Gong
    • Yu‑Hang Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China, Department of Pharmacology, Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China
  • Pages: 471-477
    |
    Published online on: June 10, 2014
       https://doi.org/10.3892/etm.2014.1769
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Abstract

Post‑operative cognitive dysfunction (POCD) is a severe complication characterized by cognitive decline in patients following anesthesia and surgery. Previous studies have suggested that volatile anesthetics, for example isoflurane, may contribute to such impairment. In the present study, the effects of emulsified isoflurane (EI) exposure on cognitive function, as well as the potential mechanisms, were investigated in animal models. Eight‑month‑old male rats were administered a single intravenous injection of 8% EI. The rats were then subjected to the Morris water maze test to assess their cognitive functions at different time‑points following drug administration. Samples were taken in order to detect the plasma corticosterone concentration and the levels of hippocampal brain‑derived neurotrophic factor (BDNF) and nerve growth factor (NGF), as well as the expression of BDNF and NGF in the hippocampal region. The results showed that a single injection of EI caused reversible learning and memory dysfunction in adult rats. It was found that downregulation of BDNF expression may contribute to the isoflurane‑induced cognitive impairment of these rats. Increased expression of NGF may be associated with the protection mechanism subsequent to learning and memory function decline, and therefore may accelerate the recovery of cognitive function.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Zhu ZQ, Liu DX, Zhang C, Gong QH and Zhu YH: Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats. Exp Ther Med 8: 471-477, 2014.
APA
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., & Zhu, Y. (2014). Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats. Experimental and Therapeutic Medicine, 8, 471-477. https://doi.org/10.3892/etm.2014.1769
MLA
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., Zhu, Y."Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats". Experimental and Therapeutic Medicine 8.2 (2014): 471-477.
Chicago
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., Zhu, Y."Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats". Experimental and Therapeutic Medicine 8, no. 2 (2014): 471-477. https://doi.org/10.3892/etm.2014.1769
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Zhu ZQ, Liu DX, Zhang C, Gong QH and Zhu YH: Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats. Exp Ther Med 8: 471-477, 2014.
APA
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., & Zhu, Y. (2014). Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats. Experimental and Therapeutic Medicine, 8, 471-477. https://doi.org/10.3892/etm.2014.1769
MLA
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., Zhu, Y."Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats". Experimental and Therapeutic Medicine 8.2 (2014): 471-477.
Chicago
Zhang, F., Zhu, Z., Liu, D., Zhang, C., Gong, Q., Zhu, Y."Emulsified isoflurane anesthesia decreases brain‑derived neurotrophic factor expression and induces cognitive dysfunction in adult rats". Experimental and Therapeutic Medicine 8, no. 2 (2014): 471-477. https://doi.org/10.3892/etm.2014.1769
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