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Article

Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia

  • Authors:
    • Jinghua Wang
    • Xuan Wang
    • Baosheng Lv
    • Weixiu Yuan
    • Zeguo Feng
    • Weidong Mi
    • Hong Zhang
  • View Affiliations / Copyright

    Affiliations: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China, Department of Psychiatry, Beijing Huilongguan Hospital, Beijing 100096, P.R. China
  • Pages: 671-675
    |
    Published online on: June 11, 2014
       https://doi.org/10.3892/etm.2014.1775
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Abstract

Fructus Akebiae (FAE) is a component of traditional Chinese medicines used for the clinical treatment of amnesia. The aim of the present study was to investigate the effects of FAE extract on scopolamine‑induced learning and memory impairment in mice and Sprague‑Dawley rats. Treatment with FAE (2.5, 5 and 10 mg/kg) was investigated in scopolamine‑treated animals, and its effects on different types of memory were examined using the T‑maze, the Morris water maze task, the novel object recognition test, the passive avoidance task and the step‑down test. The results revealed that 5 and 10 mg/kg FAE attenuated scopolamine‑mediated impairment of cognition, including spatial, episodic, aversive, and short‑ and long‑term memory. Overall, these results suggest that FAE is an effective cognitive enhancer, and thus highlights the value of a multi‑target strategy to address the complexity of cognitive dysfunction in Alzheimer's disease.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wang X, Lv B, Yuan W, Feng Z, Mi W and Zhang H: Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia. Exp Ther Med 8: 671-675, 2014.
APA
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., & Zhang, H. (2014). Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia. Experimental and Therapeutic Medicine, 8, 671-675. https://doi.org/10.3892/etm.2014.1775
MLA
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., Zhang, H."Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia". Experimental and Therapeutic Medicine 8.2 (2014): 671-675.
Chicago
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., Zhang, H."Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia". Experimental and Therapeutic Medicine 8, no. 2 (2014): 671-675. https://doi.org/10.3892/etm.2014.1775
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wang X, Lv B, Yuan W, Feng Z, Mi W and Zhang H: Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia. Exp Ther Med 8: 671-675, 2014.
APA
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., & Zhang, H. (2014). Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia. Experimental and Therapeutic Medicine, 8, 671-675. https://doi.org/10.3892/etm.2014.1775
MLA
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., Zhang, H."Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia". Experimental and Therapeutic Medicine 8.2 (2014): 671-675.
Chicago
Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., Zhang, H."Effects of Fructus Akebiae on learning and memory impairment in a scopolamine‑induced animal model of dementia". Experimental and Therapeutic Medicine 8, no. 2 (2014): 671-675. https://doi.org/10.3892/etm.2014.1775
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